Motif ID: Hnf1b

Z-value: 1.011


Transcription factors associated with Hnf1b:

Gene SymbolEntrez IDGene Name
Hnf1b ENSMUSG00000020679.5 Hnf1b



Activity profile for motif Hnf1b.

activity profile for motif Hnf1b


Sorted Z-values histogram for motif Hnf1b

Sorted Z-values for motif Hnf1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1b

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_106464167 9.494 ENSMUST00000049507.5
Pcsk9
proprotein convertase subtilisin/kexin type 9
chr13_-_53286052 8.894 ENSMUST00000021918.8
Ror2
receptor tyrosine kinase-like orphan receptor 2
chr7_-_144751968 8.449 ENSMUST00000155175.1
Ano1
anoctamin 1, calcium activated chloride channel
chrX_+_52791179 8.277 ENSMUST00000101588.1
Ccdc160
coiled-coil domain containing 160
chr9_-_106158109 8.238 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr11_-_76027726 7.982 ENSMUST00000021207.6
Fam101b
family with sequence similarity 101, member B
chr10_-_7212222 7.800 ENSMUST00000015346.5
Cnksr3
Cnksr family member 3
chr4_-_134767940 6.931 ENSMUST00000037828.6
Ldlrap1
low density lipoprotein receptor adaptor protein 1
chr3_+_154597352 5.855 ENSMUST00000140644.1
ENSMUST00000144764.1
ENSMUST00000155232.1
Cryz


crystallin, zeta


chr2_+_167777467 5.415 ENSMUST00000139927.1
ENSMUST00000127441.1
Gm14321

predicted gene 14321

chr19_+_23723279 5.382 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr9_+_99629496 5.129 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
Dzip1l


DAZ interacting protein 1-like


chr1_-_4880669 4.996 ENSMUST00000078030.3
Gm6104
predicted gene 6104
chr13_+_89540636 4.907 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr3_-_138131356 4.767 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr9_+_15520830 4.527 ENSMUST00000178999.1
Smco4
single-pass membrane protein with coiled-coil domains 4
chr10_-_76110956 4.507 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr1_+_19208914 4.413 ENSMUST00000027059.4
Tfap2b
transcription factor AP-2 beta
chr15_-_36598019 4.359 ENSMUST00000155116.1
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr9_+_99629823 4.329 ENSMUST00000112886.2
Dzip1l
DAZ interacting protein 1-like
chr8_-_92355764 4.190 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr3_-_150073620 3.943 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr17_+_47737030 3.931 ENSMUST00000086932.3
Tfeb
transcription factor EB
chr18_-_66022580 3.920 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr7_-_28962223 3.811 ENSMUST00000127210.1
Actn4
actinin alpha 4
chr2_+_158768083 3.725 ENSMUST00000029183.2
Fam83d
family with sequence similarity 83, member D
chr10_+_61089327 3.691 ENSMUST00000020298.6
Pcbd1
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr15_-_103215285 3.674 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
Cbx5


chromobox 5


chr18_+_4993795 3.637 ENSMUST00000153016.1
Svil
supervillin
chr16_-_16146771 3.617 ENSMUST00000040248.7
Spidr
scaffolding protein involved i DNA repair
chr19_-_14598031 3.503 ENSMUST00000167776.2
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr6_-_128437653 3.481 ENSMUST00000151796.1
Fkbp4
FK506 binding protein 4
chr7_-_28962265 3.214 ENSMUST00000068045.7
Actn4
actinin alpha 4
chr19_-_14597983 3.157 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr11_-_11898044 2.812 ENSMUST00000066237.3
Ddc
dopa decarboxylase
chr14_+_46882854 2.784 ENSMUST00000022386.8
ENSMUST00000100672.3
Samd4

sterile alpha motif domain containing 4

chr1_+_58795371 2.699 ENSMUST00000027189.8
Casp8
caspase 8
chr5_-_121527186 2.687 ENSMUST00000152270.1
Mapkapk5
MAP kinase-activated protein kinase 5
chr7_+_100537192 2.679 ENSMUST00000120454.1
Coa4
cytochrome c oxidase assembly factor 4
chr7_+_141215852 2.630 ENSMUST00000046890.5
ENSMUST00000133763.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr11_-_11898092 2.534 ENSMUST00000178704.1
Ddc
dopa decarboxylase
chr17_-_71459300 2.505 ENSMUST00000183937.1
Gm4707
predicted gene 4707
chr4_+_43957401 2.502 ENSMUST00000030202.7
Glipr2
GLI pathogenesis-related 2
chr11_+_78178105 2.480 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chr1_+_74661794 2.197 ENSMUST00000129890.1
Ttll4
tubulin tyrosine ligase-like family, member 4
chr7_+_141216626 2.178 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr11_+_3983636 2.128 ENSMUST00000078757.1
Gal3st1
galactose-3-O-sulfotransferase 1
chr14_-_20496780 2.050 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr8_+_95715901 1.958 ENSMUST00000034096.4
Setd6
SET domain containing 6
chr18_+_55057557 1.939 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chrX_+_101449078 1.903 ENSMUST00000033674.5
Itgb1bp2
integrin beta 1 binding protein 2
chr11_+_85832551 1.884 ENSMUST00000000095.6
Tbx2
T-box 2
chr4_+_150853919 1.883 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr15_-_100425050 1.858 ENSMUST00000123461.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr19_+_60889749 1.852 ENSMUST00000003313.8
Grk5
G protein-coupled receptor kinase 5
chr13_-_55536504 1.838 ENSMUST00000021956.8
Ddx41
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
chr10_-_116549101 1.824 ENSMUST00000164088.1
Cnot2
CCR4-NOT transcription complex, subunit 2
chr11_+_23665615 1.782 ENSMUST00000109525.1
ENSMUST00000020520.4
Pus10

pseudouridylate synthase 10

chr4_-_150909428 1.753 ENSMUST00000128075.1
ENSMUST00000105674.1
ENSMUST00000105673.1
Park7


Parkinson disease (autosomal recessive, early onset) 7


chr17_-_35132050 1.640 ENSMUST00000025249.6
Apom
apolipoprotein M
chr13_+_83738874 1.605 ENSMUST00000052354.4
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr8_+_68276567 1.579 ENSMUST00000066594.3
Sh2d4a
SH2 domain containing 4A
chr7_+_119561699 1.557 ENSMUST00000167935.2
ENSMUST00000130583.1
Acsm2

acyl-CoA synthetase medium-chain family member 2

chr6_+_73248382 1.547 ENSMUST00000064740.6
Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
chr1_-_36273425 1.539 ENSMUST00000056946.6
Neurl3
neuralized homolog 3 homolog (Drosophila)
chr1_+_133246092 1.507 ENSMUST00000038295.8
ENSMUST00000105082.2
Plekha6

pleckstrin homology domain containing, family A member 6

chr5_-_114444036 1.501 ENSMUST00000031560.7
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr10_-_30842765 1.481 ENSMUST00000019924.8
Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr17_+_17374332 1.435 ENSMUST00000024620.6
Riok2
RIO kinase 2 (yeast)
chr11_+_3983704 1.434 ENSMUST00000063004.7
Gal3st1
galactose-3-O-sulfotransferase 1
chr9_+_53771499 1.419 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr9_-_61914538 1.361 ENSMUST00000008036.7
Rplp1
ribosomal protein, large, P1
chr4_+_11758147 1.358 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr6_+_38918969 1.297 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr15_+_85510812 1.231 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr4_-_117682233 1.211 ENSMUST00000102687.3
Dmap1
DNA methyltransferase 1-associated protein 1
chr7_+_33653440 1.204 ENSMUST00000151344.1
Gm12763
predicted gene 12763
chr14_+_48446128 1.203 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr12_+_87443896 1.193 ENSMUST00000161023.1
ENSMUST00000160488.1
ENSMUST00000077462.7
ENSMUST00000160880.1
Slirp



SRA stem-loop interacting RNA binding protein



chr14_+_79515618 1.150 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr2_+_151494274 1.116 ENSMUST00000028949.9
ENSMUST00000103160.4
Nsfl1c

NSFL1 (p97) cofactor (p47)

chr4_-_41045381 1.059 ENSMUST00000054945.7
Aqp7
aquaporin 7
chr9_-_71163224 1.016 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr14_+_48446340 1.016 ENSMUST00000111735.2
Tmem260
transmembrane protein 260
chr15_-_50890396 1.011 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr15_-_79285502 0.942 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr2_-_155357392 0.888 ENSMUST00000165234.1
ENSMUST00000077626.6
Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr5_-_87490869 0.884 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chrM_+_2743 0.878 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr4_+_48279794 0.874 ENSMUST00000030029.3
Invs
inversin
chr7_-_119895446 0.847 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr2_+_151494182 0.832 ENSMUST00000089140.6
Nsfl1c
NSFL1 (p97) cofactor (p47)
chr10_+_63061582 0.727 ENSMUST00000020266.8
ENSMUST00000178684.1
Pbld1

phenazine biosynthesis-like protein domain containing 1

chr19_+_42045792 0.711 ENSMUST00000172244.1
ENSMUST00000081714.4
Hoga1

4-hydroxy-2-oxoglutarate aldolase 1

chr5_-_38491948 0.700 ENSMUST00000129099.1
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr14_+_118787894 0.658 ENSMUST00000047761.6
ENSMUST00000071546.7
Cldn10

claudin 10

chr9_+_95857597 0.580 ENSMUST00000034980.7
Atr
ataxia telangiectasia and Rad3 related
chr10_-_89621253 0.508 ENSMUST00000020102.7
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr2_+_173737492 0.499 ENSMUST00000067530.4
Vapb
vesicle-associated membrane protein, associated protein B and C
chr12_-_87444017 0.464 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr8_-_8690493 0.462 ENSMUST00000048545.8
Arglu1
arginine and glutamate rich 1
chr9_+_54980880 0.454 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr11_+_44518959 0.452 ENSMUST00000019333.3
Rnf145
ring finger protein 145
chrX_-_95444789 0.439 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr9_+_109096659 0.429 ENSMUST00000130366.1
Plxnb1
plexin B1
chr15_-_96699698 0.424 ENSMUST00000023099.6
Slc38a2
solute carrier family 38, member 2
chr18_+_35599219 0.415 ENSMUST00000115734.1
Paip2
polyadenylate-binding protein-interacting protein 2
chr19_-_30549516 0.387 ENSMUST00000025803.8
Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr11_+_110968056 0.374 ENSMUST00000125692.1
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_-_45062393 0.315 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr5_-_123666682 0.289 ENSMUST00000149410.1
Clip1
CAP-GLY domain containing linker protein 1
chr8_+_117095854 0.252 ENSMUST00000034308.8
ENSMUST00000167370.1
ENSMUST00000176860.1
Bcmo1


beta-carotene 15,15'-monooxygenase


chr5_-_114443993 0.234 ENSMUST00000112245.1
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr5_-_108675569 0.222 ENSMUST00000051757.7
Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr7_-_45103747 0.211 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr7_-_6011010 0.205 ENSMUST00000086338.1
Vmn1r65
vomeronasal 1 receptor 65
chr8_-_22694061 0.201 ENSMUST00000131767.1
Ikbkb
inhibitor of kappaB kinase beta
chr6_-_102464667 0.145 ENSMUST00000032159.6
Cntn3
contactin 3
chr13_-_93674300 0.137 ENSMUST00000015941.7
Bhmt2
betaine-homocysteine methyltransferase 2
chr11_+_78465697 0.126 ENSMUST00000001126.3
Slc46a1
solute carrier family 46, member 1
chr16_+_24448082 0.115 ENSMUST00000078988.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr9_-_44767792 0.113 ENSMUST00000034607.9
Arcn1
archain 1
chr8_+_95332279 0.112 ENSMUST00000034245.8
Usb1
U6 snRNA biogenesis 1
chr17_+_74395607 0.112 ENSMUST00000179074.1
ENSMUST00000024870.6
Slc30a6

solute carrier family 30 (zinc transporter), member 6

chr6_+_48647224 0.090 ENSMUST00000078223.3
Gimap8
GTPase, IMAP family member 8
chr2_+_91265252 0.086 ENSMUST00000028691.6
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr16_+_33251415 0.079 ENSMUST00000023502.4
Snx4
sorting nexin 4
chr4_-_53262547 0.047 ENSMUST00000098075.2
AI427809
expressed sequence AI427809
chr7_-_29505447 0.032 ENSMUST00000183096.1
ENSMUST00000085809.4
Sipa1l3

signal-induced proliferation-associated 1 like 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
2.7 8.0 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
2.3 7.0 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
1.8 8.9 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
1.7 8.4 GO:0015705 iodide transport(GO:0015705)
1.5 4.4 GO:0097274 urea homeostasis(GO:0097274)
1.2 3.6 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
1.0 4.8 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.9 5.3 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.9 4.4 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.8 4.5 GO:0035428 hexose transmembrane transport(GO:0035428)
0.7 3.6 GO:0072757 cellular response to camptothecin(GO:0072757)
0.6 1.9 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.6 1.9 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.6 1.8 GO:0050787 glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) glyoxal catabolic process(GO:1903190) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) positive regulation of androgen receptor activity(GO:2000825)
0.6 6.9 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.5 1.5 GO:0003195 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.5 3.7 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.5 1.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.4 1.6 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.4 1.2 GO:1902369 negative regulation of RNA catabolic process(GO:1902369)
0.4 5.9 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.4 1.9 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.3 2.7 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.3 2.7 GO:0090400 stress-induced premature senescence(GO:0090400)
0.3 1.9 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.3 2.1 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.3 1.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 7.8 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.3 1.6 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.2 2.0 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.2 2.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.2 2.7 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.2 0.7 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.2 0.9 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.2 1.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 1.8 GO:0033147 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.2 3.5 GO:0006825 copper ion transport(GO:0006825)
0.2 0.6 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.2 0.7 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.2 1.5 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.2 1.9 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 0.9 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.9 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.4 GO:1904956 regulation of endodermal cell fate specification(GO:0042663) motor learning(GO:0061743) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 0.5 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.1 3.7 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.1 0.4 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 1.8 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 0.4 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.3 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 1.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 3.9 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 0.7 GO:0046415 urate metabolic process(GO:0046415)
0.1 1.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.8 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 0.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.8 GO:0010225 response to UV-C(GO:0010225)
0.1 3.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 1.0 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.5 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.4 GO:0015838 amino-acid betaine transport(GO:0015838)
0.0 2.5 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 0.9 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.2 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.1 GO:0071267 amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 3.6 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.0 2.4 GO:0045727 positive regulation of translation(GO:0045727)
0.0 1.4 GO:0006414 translational elongation(GO:0006414)
0.0 0.5 GO:0015813 L-glutamate transport(GO:0015813)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 6.7 GO:0016055 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
0.0 0.1 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.0 0.1 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
1.7 6.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.9 2.7 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.6 1.9 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.5 1.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.4 7.0 GO:0031143 pseudopodium(GO:0031143)
0.4 1.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.4 1.9 GO:0070826 paraferritin complex(GO:0070826)
0.3 3.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.3 4.8 GO:0031528 microvillus membrane(GO:0031528)
0.3 0.9 GO:0097543 ciliary inversin compartment(GO:0097543)
0.3 1.5 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 3.9 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.2 4.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 8.4 GO:0034707 chloride channel complex(GO:0034707)
0.2 2.7 GO:0032156 septin cytoskeleton(GO:0032156)
0.2 3.7 GO:0010369 chromocenter(GO:0010369)
0.1 0.9 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 3.6 GO:0043034 costamere(GO:0043034)
0.1 0.9 GO:0071439 clathrin complex(GO:0071439)
0.1 9.5 GO:0005814 centriole(GO:0005814)
0.1 1.9 GO:0030018 Z disc(GO:0030018)
0.1 1.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 3.5 GO:0044295 axonal growth cone(GO:0044295)
0.1 4.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 4.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.2 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 4.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.2 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.9 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0034190 apolipoprotein receptor binding(GO:0034190)
2.1 8.4 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
1.3 5.3 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.9 3.6 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.8 6.9 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.7 3.5 GO:0032767 copper-dependent protein binding(GO:0032767)
0.7 2.7 GO:0035877 death effector domain binding(GO:0035877)
0.6 1.8 GO:0044388 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) small protein activating enzyme binding(GO:0044388) cupric ion binding(GO:1903135) cuprous ion binding(GO:1903136) glyoxalase (glycolic acid-forming) activity(GO:1990422)
0.5 3.7 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.5 8.0 GO:0031005 filamin binding(GO:0031005)
0.5 1.5 GO:0035939 microsatellite binding(GO:0035939)
0.5 1.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.4 1.6 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.4 1.9 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.4 1.9 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.3 5.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.3 2.1 GO:0015265 urea channel activity(GO:0015265)
0.3 5.9 GO:0070402 NADPH binding(GO:0070402)
0.3 4.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.3 8.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 4.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 3.9 GO:0005537 mannose binding(GO:0005537)
0.3 1.8 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.2 4.8 GO:0008143 poly(A) binding(GO:0008143)
0.2 0.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 0.9 GO:0034235 GPI anchor binding(GO:0034235)
0.2 3.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 11.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 1.8 GO:0034951 pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)
0.1 2.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 7.0 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 0.4 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 1.5 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.1 2.8 GO:0030371 translation repressor activity(GO:0030371)
0.1 1.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.6 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 3.7 GO:0019894 kinesin binding(GO:0019894)
0.1 2.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.8 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.5 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.6 GO:0016209 antioxidant activity(GO:0016209)
0.0 1.8 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.3 GO:0004497 monooxygenase activity(GO:0004497)
0.0 1.6 GO:0019902 phosphatase binding(GO:0019902)
0.0 1.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 3.6 GO:0051015 actin filament binding(GO:0051015)
0.0 3.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 6.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 1.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)