Motif ID: Hoxa1

Z-value: 0.875


Transcription factors associated with Hoxa1:

Gene SymbolEntrez IDGene Name
Hoxa1 ENSMUSG00000029844.9 Hoxa1



Activity profile for motif Hoxa1.

activity profile for motif Hoxa1


Sorted Z-values histogram for motif Hoxa1

Sorted Z-values for motif Hoxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_15239045 8.557 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr14_+_70077375 4.849 ENSMUST00000035908.1
 Egr3
early growth response 3
chr2_+_163225363 4.116 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr2_+_158375638 3.614 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr10_+_79988584 3.494 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr8_-_11312731 3.383 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr13_+_72628802 3.341 ENSMUST00000074372.4
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr4_-_143299498 2.941 ENSMUST00000030317.7
 Pdpn
podoplanin
chr14_-_103844173 2.780 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr10_+_81628702 2.623 ENSMUST00000129622.1
 Ankrd24
ankyrin repeat domain 24
chr8_-_117673682 2.499 ENSMUST00000173522.1
ENSMUST00000174450.1
 Sdr42e1

short chain dehydrogenase/reductase family 42E, member 1

chr4_-_106799779 2.375 ENSMUST00000145061.1
ENSMUST00000102762.3
 Acot11

acyl-CoA thioesterase 11

chr2_+_152962485 2.323 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chrX_+_110814390 2.186 ENSMUST00000078229.3
 Pou3f4
POU domain, class 3, transcription factor 4
chr17_+_70522083 2.110 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr5_+_27261916 2.071 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6
chr6_-_52012476 2.025 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2
chr11_+_103774150 2.020 ENSMUST00000000127.5
 Wnt3
wingless-related MMTV integration site 3
chr13_+_72628831 1.968 ENSMUST00000169028.1
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr13_+_31806627 1.958 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr13_-_12340723 1.879 ENSMUST00000168193.1
ENSMUST00000110616.1
ENSMUST00000064204.7
 Actn2


actinin alpha 2


chr10_+_94576254 1.874 ENSMUST00000117929.1
 Tmcc3
transmembrane and coiled coil domains 3
chr1_-_45503282 1.838 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr5_-_135573036 1.836 ENSMUST00000004936.6
 Ccl24
chemokine (C-C motif) ligand 24
chr15_-_95528702 1.804 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr17_+_70522149 1.795 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr15_+_74516196 1.761 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr11_-_20332654 1.544 ENSMUST00000004634.6
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr7_+_73391160 1.342 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr6_-_136875794 1.324 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr4_-_143299463 1.302 ENSMUST00000119654.1
 Pdpn
podoplanin
chr9_-_4796218 1.292 ENSMUST00000027020.6
ENSMUST00000063508.7
ENSMUST00000163309.1
 Gria4


glutamate receptor, ionotropic, AMPA4 (alpha 4)


chr15_+_98167806 1.262 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr1_+_89454769 1.214 ENSMUST00000027521.8
ENSMUST00000074945.5
 Agap1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr3_-_110143937 1.167 ENSMUST00000051253.3
 Ntng1
netrin G1
chr3_+_68572245 1.161 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr2_-_148045891 1.119 ENSMUST00000109964.1
 Foxa2
forkhead box A2
chr5_+_137030275 1.109 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chr14_+_66344369 1.061 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr14_+_66344296 1.028 ENSMUST00000152093.1
ENSMUST00000074523.6
 Stmn4

stathmin-like 4

chr9_-_21312255 1.013 ENSMUST00000115433.3
ENSMUST00000003397.7
 Ap1m2

adaptor protein complex AP-1, mu 2 subunit

chr15_+_82252397 0.967 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr10_+_75037291 0.893 ENSMUST00000139384.1
 Rab36
RAB36, member RAS oncogene family
chr5_-_137684665 0.885 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr14_-_69503316 0.884 ENSMUST00000179116.2
 Gm21464
predicted gene, 21464
chr15_-_53346118 0.859 ENSMUST00000077273.2
 Ext1
exostoses (multiple) 1
chr10_+_81628570 0.801 ENSMUST00000153573.1
ENSMUST00000119336.1
 Ankrd24

ankyrin repeat domain 24

chr11_-_102296618 0.801 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr2_-_152951688 0.785 ENSMUST00000109811.3
 Dusp15
dual specificity phosphatase-like 15
chr14_+_56575603 0.746 ENSMUST00000161553.1
 Parp4
poly (ADP-ribose) polymerase family, member 4
chr3_+_55782500 0.734 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr9_+_58129062 0.693 ENSMUST00000085677.2
 Stra6
stimulated by retinoic acid gene 6
chr9_+_58129321 0.687 ENSMUST00000034880.3
 Stra6
stimulated by retinoic acid gene 6
chr2_+_36230426 0.687 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr4_-_108406676 0.668 ENSMUST00000184609.1
 Gpx7
glutathione peroxidase 7
chr17_-_25081138 0.625 ENSMUST00000024984.6
 Tmem204
transmembrane protein 204
chr11_-_40755201 0.618 ENSMUST00000020576.7
 Ccng1
cyclin G1
chrX_-_150812932 0.596 ENSMUST00000131241.1
ENSMUST00000147152.1
ENSMUST00000143843.1
 Maged2


melanoma antigen, family D, 2


chr18_+_40258361 0.595 ENSMUST00000091927.4
 Kctd16
potassium channel tetramerisation domain containing 16
chr5_-_107289561 0.584 ENSMUST00000031224.8
 Tgfbr3
transforming growth factor, beta receptor III
chr9_-_101034857 0.525 ENSMUST00000142676.1
ENSMUST00000149322.1
 Pccb

propionyl Coenzyme A carboxylase, beta polypeptide

chr9_+_59589288 0.525 ENSMUST00000121266.1
ENSMUST00000118164.1
 Celf6

CUGBP, Elav-like family member 6

chr4_+_119814495 0.521 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr12_+_53248677 0.515 ENSMUST00000101432.2
 Npas3
neuronal PAS domain protein 3
chrX_-_150813637 0.513 ENSMUST00000112700.1
 Maged2
melanoma antigen, family D, 2
chr10_+_26078255 0.512 ENSMUST00000041011.3
 Gm9767
predicted gene 9767
chr11_-_116189542 0.493 ENSMUST00000148601.1
 Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr18_-_56562215 0.476 ENSMUST00000170309.1
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr10_-_78352469 0.468 ENSMUST00000138035.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr5_-_145201829 0.462 ENSMUST00000162220.1
ENSMUST00000031632.8
 Zkscan14

zinc finger with KRAB and SCAN domains 14

chr2_+_65845833 0.449 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr18_+_4994600 0.401 ENSMUST00000140448.1
 Svil
supervillin
chr3_-_88762244 0.372 ENSMUST00000183267.1
 Syt11
synaptotagmin XI
chr3_+_114030532 0.356 ENSMUST00000123619.1
ENSMUST00000092155.5
 Col11a1

collagen, type XI, alpha 1

chr17_+_55445375 0.340 ENSMUST00000133899.1
ENSMUST00000086878.3
 St6gal2

beta galactoside alpha 2,6 sialyltransferase 2

chr10_+_81628540 0.318 ENSMUST00000123896.1
 Ankrd24
ankyrin repeat domain 24
chr15_+_9140527 0.288 ENSMUST00000090380.4
 Lmbrd2
LMBR1 domain containing 2
chr9_+_110344185 0.241 ENSMUST00000142100.1
 Scap
SREBF chaperone
chr6_+_48395652 0.230 ENSMUST00000077093.4
 Krba1
KRAB-A domain containing 1
chr18_-_56562261 0.195 ENSMUST00000066208.6
ENSMUST00000172734.1
 Aldh7a1

aldehyde dehydrogenase family 7, member A1

chr18_-_56562187 0.192 ENSMUST00000171844.2
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chrX_+_56454871 0.179 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr11_+_62281457 0.165 ENSMUST00000101075.4
ENSMUST00000050646.6
 Ttc19

tetratricopeptide repeat domain 19

chr16_-_18876655 0.131 ENSMUST00000023391.8
 Mrpl40
mitochondrial ribosomal protein L40
chr6_+_48395586 0.125 ENSMUST00000114571.1
ENSMUST00000114572.3
ENSMUST00000031815.5
 Krba1


KRAB-A domain containing 1


chr7_-_127708886 0.113 ENSMUST00000061468.8
 Bcl7c
B cell CLL/lymphoma 7C
chr2_+_119972699 0.098 ENSMUST00000066058.7
 Mapkbp1
mitogen-activated protein kinase binding protein 1
chr5_-_143732273 0.093 ENSMUST00000053287.5
 Usp42
ubiquitin specific peptidase 42
chr7_+_144838590 0.067 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr16_+_18877037 0.066 ENSMUST00000120532.1
ENSMUST00000004222.7
 Hira

histone cell cycle regulation defective homolog A (S. cerevisiae)

chr7_+_119690026 0.061 ENSMUST00000047045.8
 Acsm4
acyl-CoA synthetase medium-chain family member 4
chrX_-_8132770 0.058 ENSMUST00000130832.1
ENSMUST00000033506.6
ENSMUST00000115623.1
ENSMUST00000153839.1
 Wdr13



WD repeat domain 13



chr7_-_30534180 0.053 ENSMUST00000044338.4
 Arhgap33
Rho GTPase activating protein 33
chr1_-_157412576 0.052 ENSMUST00000078308.6
ENSMUST00000139470.1
 Rasal2

RAS protein activator like 2

chr9_+_58129476 0.017 ENSMUST00000133287.1
 Stra6
stimulated by retinoic acid gene 6
chr17_-_90455872 0.014 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr10_-_81545175 0.001 ENSMUST00000043604.5
 Gna11
guanine nucleotide binding protein, alpha 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.7 2.0 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.7 2.0 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.6 1.9 GO:0051695 actin filament uncapping(GO:0051695)
0.6 1.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.6 1.8 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.5 3.4 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.4 4.8 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.4 4.8 GO:0061032 visceral serous pericardium development(GO:0061032)
0.4 1.1 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.3 3.9 GO:0070842 aggresome assembly(GO:0070842)
0.3 0.9 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.3 1.4 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.2 2.2 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 3.9 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.2 1.5 GO:0015808 L-alanine transport(GO:0015808)
0.2 1.8 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 1.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 0.5 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 1.1 GO:0043084 penile erection(GO:0043084)
0.1 1.2 GO:0001553 luteinization(GO:0001553)
0.1 0.4 GO:0035989 tendon development(GO:0035989)
0.1 0.5 GO:0042711 maternal behavior(GO:0042711)
0.0 1.3 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0 2.1 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.0 2.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.5 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.8 GO:0016578 histone deubiquitination(GO:0016578)
0.0 1.3 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 2.7 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 0.6 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.7 GO:0006278 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
0.0 2.0 GO:0002757 immune response-activating signal transduction(GO:0002757)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.4 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.6 1.8 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 0.6 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 1.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.8 GO:0000124 SAGA complex(GO:0000124)
0.1 0.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 3.7 GO:0030175 filopodium(GO:0030175)
0.0 2.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.5 GO:0005882 intermediate filament(GO:0005882)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.1 GO:0030667 secretory granule membrane(GO:0030667)
0.0 4.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.8 GO:0043204 perikaryon(GO:0043204)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 0.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.7 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.8 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0004962 endothelin receptor activity(GO:0004962)
0.4 2.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.4 4.2 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.2 1.9 GO:0031432 thyroid hormone receptor coactivator activity(GO:0030375) titin binding(GO:0031432)
0.2 3.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 0.9 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.2 2.2 GO:0003680 AT DNA binding(GO:0003680)
0.2 1.5 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.2 1.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 0.5 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.2 2.0 GO:0048018 receptor agonist activity(GO:0048018)
0.2 0.7 GO:0004096 catalase activity(GO:0004096)
0.2 2.0 GO:0008301 DNA binding, bending(GO:0008301)
0.1 3.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.4 GO:0034946 2-oxoglutaryl-CoA thioesterase activity(GO:0034843) 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity(GO:0034869) 3-isopropylbut-3-enoyl-CoA thioesterase activity(GO:0034946) glutaryl-CoA hydrolase activity(GO:0044466)
0.1 1.3 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 0.5 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.1 1.4 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 2.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.6 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 4.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.8 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)
0.0 3.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.1 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)