Motif ID: Hoxa7_Hoxc8

Z-value: 0.617

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8



Activity profile for motif Hoxa7_Hoxc8.

activity profile for motif Hoxa7_Hoxc8


Sorted Z-values histogram for motif Hoxa7_Hoxc8

Sorted Z-values for motif Hoxa7_Hoxc8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710409 8.656 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 8.159 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrX_-_143933204 5.776 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 5.761 ENSMUST00000087313.3
 Dcx
doublecortin
chr5_-_62766153 5.671 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_45885479 3.090 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr15_-_37458523 2.806 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr1_+_72284367 2.752 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr14_-_100149764 2.433 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr14_+_80000292 2.233 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr6_-_137169710 2.075 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr4_+_102589687 1.936 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr3_+_55461758 1.905 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr9_-_55919605 1.897 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr3_-_66296807 1.851 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1
chr18_-_10706688 1.709 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
 Abhd3


abhydrolase domain containing 3


chr6_+_63255971 1.690 ENSMUST00000159561.1
ENSMUST00000095852.3
 Grid2

glutamate receptor, ionotropic, delta 2

chr2_+_69897255 1.605 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr18_+_37518341 1.581 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chr8_+_94152607 1.564 ENSMUST00000034211.8
 Mt3
metallothionein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 16.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.6 11.5 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 3.7 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 3.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.7 2.9 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 2.8 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 2.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 1.7 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.5 1.6 GO:0097212 lysosomal membrane organization(GO:0097212)
0.2 1.3 GO:0019532 oxalate transport(GO:0019532)
0.1 1.3 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 1.1 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.0 1.0 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 1.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 0.9 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.9 GO:0001504 neurotransmitter uptake(GO:0001504)
0.3 0.8 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 16.8 GO:0043205 fibril(GO:0043205)
0.0 12.1 GO:0005874 microtubule(GO:0005874)
0.0 3.1 GO:0030018 Z disc(GO:0030018)
0.2 2.2 GO:0042581 specific granule(GO:0042581)
0.0 2.0 GO:0031672 A band(GO:0031672)
0.1 1.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.7 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 1.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.6 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.1 GO:0097433 dense body(GO:0097433)
0.1 1.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 0.8 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.3 0.8 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.7 GO:0034464 BBSome(GO:0034464)
0.1 0.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 16.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.5 11.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 6.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 3.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 2.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.7 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 2.2 GO:0045296 cadherin binding(GO:0045296)
0.6 1.7 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 1.7 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.3 1.3 GO:0034235 GPI anchor binding(GO:0034235)
0.1 1.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.2 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.2 1.1 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 1.1 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 1.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.0 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.8 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.1 0.8 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.8 GO:0019208 phosphatase regulator activity(GO:0019208)