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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr15_-_8710409	8.656	ENSMUST00000157065.1	Slc1a3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734	8.159	ENSMUST00000005493.7	Slc1a3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrX_-_143933204	5.776	ENSMUST00000112851.1 ENSMUST00000112856.2 ENSMUST00000033642.3	Dcx	doublecortin
chrX_-_143933089	5.761	ENSMUST00000087313.3	Dcx	doublecortin
chr5_-_62766153	5.671	ENSMUST00000076623.4	Arap2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_45885479	3.090	ENSMUST00000034053.5	Pdlim3	PDZ and LIM domain 3
chr15_-_37458523	2.806	ENSMUST00000116445.2	Ncald	neurocalcin delta
chr1_+_72284367	2.752	ENSMUST00000027380.5 ENSMUST00000141783.1	Tmem169	transmembrane protein 169
chr14_-_100149764	2.433	ENSMUST00000097079.4	Klf12	Kruppel-like factor 12
chr14_+_80000292	2.233	ENSMUST00000088735.3	Olfm4	olfactomedin 4
chr6_-_137169710	2.075	ENSMUST00000117919.1	Rerg	RAS-like, estrogen-regulated, growth-inhibitor
chr4_+_102589687	1.936	ENSMUST00000097949.4 ENSMUST00000106901.1	Pde4b	phosphodiesterase 4B, cAMP specific
chr3_+_55461758	1.905	ENSMUST00000070418.4	Dclk1	doublecortin-like kinase 1
chr9_-_55919605	1.897	ENSMUST00000037408.8	Scaper	S phase cyclin A-associated protein in the ER
chr3_-_66296807	1.851	ENSMUST00000029419.7	Veph1	ventricular zone expressed PH domain-containing 1
chr18_-_10706688	1.709	ENSMUST00000002549.7 ENSMUST00000117726.1 ENSMUST00000117828.1	Abhd3	abhydrolase domain containing 3
chr6_+_63255971	1.690	ENSMUST00000159561.1 ENSMUST00000095852.3	Grid2	glutamate receptor, ionotropic, delta 2
chr2_+_69897255	1.605	ENSMUST00000131553.1	Ubr3	ubiquitin protein ligase E3 component n-recognin 3
chr18_+_37518341	1.581	ENSMUST00000097609.1	Pcdhb22	protocadherin beta 22
chr8_+_94152607	1.564	ENSMUST00000034211.8	Mt3	metallothionein 3
chr19_-_50678642	1.522	ENSMUST00000072685.6 ENSMUST00000164039.2	Sorcs1	VPS10 domain receptor protein SORCS 1
chr2_+_69897220	1.320	ENSMUST00000055758.9 ENSMUST00000112251.2	Ubr3	ubiquitin protein ligase E3 component n-recognin 3
chr10_+_23894688	1.269	ENSMUST00000041416.7	Vnn1	vanin 1
chr1_-_127840290	1.180	ENSMUST00000061512.2	Map3k19	mitogen-activated protein kinase kinase kinase 19
chr6_-_118479237	1.169	ENSMUST00000161170.1	Zfp9	zinc finger protein 9
chr13_+_42681513	1.148	ENSMUST00000149235.1	Phactr1	phosphatase and actin regulator 1
chr4_-_14621805	1.129	ENSMUST00000042221.7	Slc26a7	solute carrier family 26, member 7
chr9_-_103228420	1.060	ENSMUST00000126359.1	Trf	transferrin
chr14_-_108914237	1.058	ENSMUST00000100322.2	Slitrk1	SLIT and NTRK-like family, member 1
chr1_-_134955847	1.024	ENSMUST00000168381.1	Ppp1r12b	protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr11_+_29373618	1.017	ENSMUST00000040182.6 ENSMUST00000109477.1	Ccdc88a	coiled coil domain containing 88A
chr6_+_145934113	0.998	ENSMUST00000032383.7	Sspn	sarcospan
chr5_+_66968416	0.975	ENSMUST00000038188.7	Limch1	LIM and calponin homology domains 1
chr14_-_36919314	0.966	ENSMUST00000182797.1	Ccser2	coiled-coil serine rich 2
chr1_-_134955908	0.956	ENSMUST00000045665.6 ENSMUST00000086444.4 ENSMUST00000112163.1	Ppp1r12b	protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr15_-_67113909	0.954	ENSMUST00000092640.5	St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr5_+_66968559	0.937	ENSMUST00000127184.1	Limch1	LIM and calponin homology domains 1
chr7_+_35802593	0.905	ENSMUST00000052454.2	E130304I02Rik	RIKEN cDNA E130304I02 gene
chr7_+_51621830	0.896	ENSMUST00000032710.5	Slc17a6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr10_+_97482350	0.893	ENSMUST00000163448.2	Dcn	decorin
chr2_+_83724397	0.845	ENSMUST00000028499.4 ENSMUST00000141725.1 ENSMUST00000111740.2	Itgav	integrin alpha V
chr9_+_113812547	0.795	ENSMUST00000166734.2 ENSMUST00000111838.2 ENSMUST00000163895.2	Clasp2	CLIP associating protein 2
chr5_-_62765618	0.780	ENSMUST00000159470.1	Arap2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_23753708	0.771	ENSMUST00000115830.1	Mapre2	microtubule-associated protein, RP/EB family, member 2
chr10_-_20725023	0.768	ENSMUST00000020165.7	Pde7b	phosphodiesterase 7B
chr3_-_86548268	0.725	ENSMUST00000077524.3	Mab21l2	mab-21-like 2 (C. elegans)
chr7_+_126950687	0.722	ENSMUST00000106333.1	Sez6l2	seizure related 6 homolog like 2
chr2_-_79456750	0.710	ENSMUST00000041099.4	Neurod1	neurogenic differentiation 1
chr19_-_53944621	0.703	ENSMUST00000135402.2	Bbip1	BBSome interacting protein 1
chr2_-_45117349	0.626	ENSMUST00000176438.2	Zeb2	zinc finger E-box binding homeobox 2
chr19_+_55895508	0.576	ENSMUST00000111646.1	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box
chr18_+_32067729	0.567	ENSMUST00000025243.3	Iws1	IWS1 homolog (S. cerevisiae)
chr9_+_110052016	0.550	ENSMUST00000164930.1 ENSMUST00000163979.1	Map4	microtubule-associated protein 4
chr17_-_45659312	0.548	ENSMUST00000120717.1	Capn11	calpain 11
chr2_+_23069210	0.526	ENSMUST00000155602.1	Acbd5	acyl-Coenzyme A binding domain containing 5
chr13_+_43785107	0.520	ENSMUST00000015540.2	Cd83	CD83 antigen
chr14_+_64589802	0.518	ENSMUST00000180610.1	A930011O12Rik	RIKEN cDNA A930011O12 gene
chr1_+_82316452	0.503	ENSMUST00000027322.7	Rhbdd1	rhomboid domain containing 1
chr5_+_29195983	0.498	ENSMUST00000160888.1 ENSMUST00000159272.1 ENSMUST00000001247.5 ENSMUST00000161398.1 ENSMUST00000160246.1	Rnf32	ring finger protein 32
chr4_-_14621494	0.483	ENSMUST00000149633.1	Slc26a7	solute carrier family 26, member 7
chr4_+_108719649	0.451	ENSMUST00000178992.1	3110021N24Rik	RIKEN cDNA 3110021N24 gene
chr15_-_75905349	0.451	ENSMUST00000127550.1	Eef1d	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr8_-_109251698	0.449	ENSMUST00000079189.3	4922502B01Rik	RIKEN cDNA 4922502B01 gene
chr14_+_54431597	0.449	ENSMUST00000089688.4	Mmp14	matrix metallopeptidase 14 (membrane-inserted)
chr17_+_88440711	0.444	ENSMUST00000112238.2 ENSMUST00000155640.1	Foxn2	forkhead box N2
chr3_+_5218516	0.438	ENSMUST00000175866.1	Zfhx4	zinc finger homeodomain 4
chr19_-_32196393	0.427	ENSMUST00000151822.1	Sgms1	sphingomyelin synthase 1
chrM_+_9870	0.415	ENSMUST00000084013.1	mt-Nd4l	mitochondrially encoded NADH dehydrogenase 4L
chr19_+_5474681	0.376	ENSMUST00000165485.1 ENSMUST00000166253.1 ENSMUST00000167371.1 ENSMUST00000167855.1 ENSMUST00000070118.7	Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2
chr3_-_59220150	0.363	ENSMUST00000170388.1	P2ry12	purinergic receptor P2Y, G-protein coupled 12
chr13_+_83732438	0.352	ENSMUST00000182701.1	C130071C03Rik	RIKEN cDNA C130071C03 gene
chr1_-_132367879	0.341	ENSMUST00000142609.1	Tmcc2	transmembrane and coiled-coil domains 2
chr17_-_29007925	0.332	ENSMUST00000009138.5 ENSMUST00000119274.1	Stk38	serine/threonine kinase 38
chr10_+_116018213	0.326	ENSMUST00000063470.4	Ptprr	protein tyrosine phosphatase, receptor type, R
chr12_-_87775755	0.299	ENSMUST00000164517.2	Gm21319	predicted gene, 21319
chr10_+_115569986	0.294	ENSMUST00000173620.1	A930009A15Rik	RIKEN cDNA A930009A15 gene
chr4_-_115133977	0.275	ENSMUST00000051400.7	Cyp4x1	cytochrome P450, family 4, subfamily x, polypeptide 1
chr10_-_117148474	0.267	ENSMUST00000020381.3	Frs2	fibroblast growth factor receptor substrate 2
chr2_+_116067213	0.262	ENSMUST00000152412.1	G630016G05Rik	RIKEN cDNA G630016G05 gene
chr11_+_102285161	0.221	ENSMUST00000156326.1	Tmub2	transmembrane and ubiquitin-like domain containing 2
chr4_-_82850721	0.220	ENSMUST00000139401.1	Zdhhc21	zinc finger, DHHC domain containing 21
chr18_+_4920509	0.215	ENSMUST00000126977.1	Svil	supervillin
chr7_-_46667375	0.192	ENSMUST00000107669.2	Tph1	tryptophan hydroxylase 1
chrM_+_14138	0.192	ENSMUST00000082421.1	mt-Cytb	mitochondrially encoded cytochrome b
chr10_+_75037066	0.189	ENSMUST00000147802.1 ENSMUST00000020391.5	Rab36	RAB36, member RAS oncogene family
chr1_-_24612700	0.183	ENSMUST00000088336.1	Gm10222	predicted gene 10222
chr3_+_5218589	0.167	ENSMUST00000177488.1	Zfhx4	zinc finger homeodomain 4
chr6_+_134640940	0.155	ENSMUST00000062755.8	Loh12cr1	loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr2_-_177267036	0.124	ENSMUST00000108963.1	Gm14409	predicted gene 14409
chr3_+_121291725	0.116	ENSMUST00000039442.7	Alg14	asparagine-linked glycosylation 14
chr4_+_100478806	0.113	ENSMUST00000133493.2 ENSMUST00000092730.3 ENSMUST00000106979.3	Ube2u	ubiquitin-conjugating enzyme E2U (putative)
chr2_+_125136692	0.111	ENSMUST00000099452.2	Ctxn2	cortexin 2
chr13_+_24801657	0.105	ENSMUST00000019276.4	BC005537	cDNA sequence BC005537
chr3_+_5218546	0.096	ENSMUST00000026284.6	Zfhx4	zinc finger homeodomain 4
chr6_+_37870786	0.081	ENSMUST00000120428.1 ENSMUST00000031859.7	Trim24	tripartite motif-containing 24
chr18_-_75697639	0.081	ENSMUST00000165559.1	Ctif	CBP80/20-dependent translation initiation factor
chrX_+_16619698	0.045	ENSMUST00000026013.5	Maoa	monoamine oxidase A

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.2	16.8	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.7	2.9	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.6	11.5	GO:0021860	pyramidal neuron development(GO:0021860)
0.5	1.6	GO:0097212	lysosomal membrane organization(GO:0097212)
0.3	0.8	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.2	0.7	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
0.2	1.3	GO:0019532	oxalate transport(GO:0019532)
0.2	0.7	GO:0060729	intestinal epithelial structure maintenance(GO:0060729)
0.2	0.5	GO:1904211	membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1	1.9	GO:1901898	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1	0.8	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1	1.1	GO:0097460	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.1	0.9	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1	0.4	GO:1904139	microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1	1.7	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1	1.3	GO:0033089	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1	0.5	GO:0051012	microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1	0.5	GO:0030242	pexophagy(GO:0030242)
0.1	0.6	GO:1903056	regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1	0.5	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.1	0.3	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.1	0.6	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.1	0.6	GO:0048625	myoblast fate commitment(GO:0048625)
0.1	0.4	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.1	2.2	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1	1.9	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	1.7	GO:0046470	phosphatidylcholine metabolic process(GO:0046470)
0.0	0.3	GO:0007351	tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0	1.0	GO:0032148	activation of protein kinase B activity(GO:0032148)
0.0	0.9	GO:0001504	neurotransmitter uptake(GO:0001504)
0.0	0.2	GO:0033762	response to glucagon(GO:0033762)
0.0	0.4	GO:0051895	chondrocyte proliferation(GO:0035988) negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.7	GO:0010172	embryonic body morphogenesis(GO:0010172)
0.0	2.8	GO:0003073	regulation of systemic arterial blood pressure(GO:0003073)
0.0	0.7	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
0.0	0.2	GO:1901162	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0	0.2	GO:0018230	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0	0.5	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.1	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0	3.7	GO:0007519	skeletal muscle tissue development(GO:0007519)
0.0	3.1	GO:0031032	actomyosin structure organization(GO:0031032)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.4	GO:0042773	ATP synthesis coupled electron transport(GO:0042773)
0.0	1.0	GO:0001578	microtubule bundle formation(GO:0001578)
0.0	0.8	GO:0051965	positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	16.8	GO:0043205	fibril(GO:0043205)
0.3	0.8	GO:0034684	integrin alphav-beta5 complex(GO:0034684)
0.3	0.8	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.2	2.2	GO:0042581	specific granule(GO:0042581)
0.1	1.1	GO:0097433	dense body(GO:0097433)
0.1	1.9	GO:0000930	gamma-tubulin complex(GO:0000930)
0.1	0.5	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1	0.6	GO:0070369	beta-catenin-TCF7L2 complex(GO:0070369)
0.1	0.7	GO:0034464	BBSome(GO:0034464)
0.1	1.0	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	2.0	GO:0031672	A band(GO:0031672)
0.0	1.6	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.5	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.4	GO:0044352	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.4	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.3	GO:0070688	MLL5-L complex(GO:0070688)
0.0	3.1	GO:0030018	Z disc(GO:0030018)
0.0	0.8	GO:0035371	microtubule plus-end(GO:0035371)
0.0	12.1	GO:0005874	microtubule(GO:0005874)
0.0	1.7	GO:0098878	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.2	GO:0045275	respiratory chain complex III(GO:0045275)
0.0	1.0	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.9	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	0.2	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.5	GO:0016235	aggresome(GO:0016235)
0.0	1.6	GO:0008021	synaptic vesicle(GO:0008021)
0.0	0.3	GO:0098644	complex of collagen trimers(GO:0098644)
0.0	0.1	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	1.3	GO:0031225	anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.4	16.8	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.6	1.7	GO:0052740	phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.5	11.5	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3	1.3	GO:0034235	GPI anchor binding(GO:0034235)
0.2	3.1	GO:0008307	structural constituent of muscle(GO:0008307)
0.2	0.8	GO:0019960	C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.2	1.1	GO:0015091	ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1	6.5	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1	1.3	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.1	1.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.4	GO:0033188	sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1	2.8	GO:0043014	alpha-tubulin binding(GO:0043014)
0.1	1.7	GO:0005234	extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1	1.1	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.1	0.2	GO:0004510	tryptophan 5-monooxygenase activity(GO:0004510)
0.1	0.8	GO:0002162	dystroglycan binding(GO:0002162)
0.1	2.7	GO:0004120	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.1	0.3	GO:0070330	aromatase activity(GO:0070330)
0.1	0.4	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	2.2	GO:0045296	cadherin binding(GO:0045296)
0.0	1.0	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.5	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.3	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.6	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.2	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.9	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.6	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.3	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.7	GO:0070888	E-box binding(GO:0070888)
0.0	0.5	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.5	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.8	GO:0019208	phosphatase regulator activity(GO:0019208)
0.0	0.4	GO:0016504	peptidase activator activity(GO:0016504)
0.0	0.0	GO:0051378	primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0	1.2	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)

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