Motif ID: Hoxa9_Hoxb9

Z-value: 0.487

Transcription factors associated with Hoxa9_Hoxb9:

Gene SymbolEntrez IDGene Name
Hoxa9 ENSMUSG00000038227.9 Hoxa9
Hoxb9 ENSMUSG00000020875.8 Hoxb9






Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa9_Hoxb9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_108591279 5.847 ENSMUST00000051145.8
ENSMUST00000139626.1
Wdr47

WD repeat domain 47

chr6_+_49822710 4.843 ENSMUST00000031843.6
Npy
neuropeptide Y
chr1_+_194619815 4.686 ENSMUST00000027952.5
Plxna2
plexin A2
chr19_-_57197435 3.261 ENSMUST00000111550.1
Ablim1
actin-binding LIM protein 1
chr19_-_57197377 3.058 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr18_-_31447383 2.987 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr15_+_81936911 2.782 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr17_-_91092715 2.696 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr15_+_81936753 2.461 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr18_+_37400845 1.927 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr4_+_144893127 1.867 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr7_+_28277706 1.835 ENSMUST00000094651.2
Eid2b
EP300 interacting inhibitor of differentiation 2B
chr8_+_93810832 1.834 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chrX_+_159840463 1.801 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr2_-_31845925 1.752 ENSMUST00000028188.7
Fibcd1
fibrinogen C domain containing 1
chr11_-_79504078 1.543 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr1_+_66386968 1.525 ENSMUST00000145419.1
Map2
microtubule-associated protein 2
chr2_-_45112890 1.488 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr8_+_112570043 1.426 ENSMUST00000034225.6
ENSMUST00000118171.1
Cntnap4

contactin associated protein-like 4

chr5_-_73191848 1.367 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr13_+_16014457 1.348 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr2_+_28205648 1.295 ENSMUST00000102879.3
ENSMUST00000028177.4
Olfm1

olfactomedin 1

chr19_-_45812291 1.252 ENSMUST00000086993.4
Kcnip2
Kv channel-interacting protein 2
chr19_-_57197496 1.247 ENSMUST00000111544.1
Ablim1
actin-binding LIM protein 1
chr5_-_145201829 1.240 ENSMUST00000162220.1
ENSMUST00000031632.8
Zkscan14

zinc finger with KRAB and SCAN domains 14

chr7_+_56050135 1.205 ENSMUST00000076226.6
Herc2
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2
chr3_+_32436376 1.107 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr4_+_74013442 1.106 ENSMUST00000098006.2
ENSMUST00000084474.5
Frmd3

FERM domain containing 3

chr19_-_57197556 1.095 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr7_-_45870928 1.036 ENSMUST00000146672.1
Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr18_-_31317043 1.031 ENSMUST00000139924.1
ENSMUST00000153060.1
Rit2

Ras-like without CAAX 2

chr16_-_52454074 0.925 ENSMUST00000023312.7
Alcam
activated leukocyte cell adhesion molecule
chr14_+_20674311 0.919 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr11_-_109298066 0.917 ENSMUST00000106706.1
Rgs9
regulator of G-protein signaling 9
chr9_-_101198999 0.913 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr7_-_141434532 0.899 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
Slc25a22



solute carrier family 25 (mitochondrial carrier, glutamate), member 22



chr9_+_121366958 0.886 ENSMUST00000045903.6
Trak1
trafficking protein, kinesin binding 1
chr17_-_15826521 0.858 ENSMUST00000170578.1
Rgmb
RGM domain family, member B
chr2_+_32395896 0.835 ENSMUST00000028162.3
Ptges2
prostaglandin E synthase 2
chr2_-_33087169 0.815 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr4_+_44012661 0.792 ENSMUST00000107849.3
ENSMUST00000107851.3
ENSMUST00000107845.3
Clta


clathrin, light polypeptide (Lca)


chr3_+_138065052 0.768 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr6_-_143947092 0.762 ENSMUST00000144289.1
ENSMUST00000111748.1
Sox5

SRY-box containing gene 5

chr7_-_127448993 0.756 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr16_-_17531019 0.730 ENSMUST00000142666.1
ENSMUST00000100125.3
Thap7

THAP domain containing 7

chr7_-_127449109 0.725 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr2_-_33086366 0.719 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr10_-_80590292 0.717 ENSMUST00000003436.5
Abhd17a
abhydrolase domain containing 17A
chr16_+_10812915 0.715 ENSMUST00000115822.1
Gm11172
predicted gene 11172
chr2_+_125136692 0.712 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr7_+_110768169 0.707 ENSMUST00000170374.1
Ampd3
adenosine monophosphate deaminase 3
chr17_-_6621267 0.661 ENSMUST00000115772.3
Tmem181c-ps
transmembrane protein 181C, pseudogene
chr3_+_98280427 0.648 ENSMUST00000090746.2
ENSMUST00000120541.1
Hmgcs2

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

chr4_-_49597860 0.641 ENSMUST00000042750.2
Tmem246
transmembrane protein 246
chr4_+_44012638 0.634 ENSMUST00000107847.3
ENSMUST00000170241.1
Clta

clathrin, light polypeptide (Lca)

chr5_-_77095225 0.618 ENSMUST00000120827.2
ENSMUST00000113453.2
Hopx

HOP homeobox

chr19_+_44203265 0.616 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr5_-_66514815 0.612 ENSMUST00000161879.1
ENSMUST00000159357.1
Apbb2

amyloid beta (A4) precursor protein-binding, family B, member 2

chr5_-_32746317 0.610 ENSMUST00000135248.1
Pisd
phosphatidylserine decarboxylase
chr6_-_143947061 0.609 ENSMUST00000124233.1
Sox5
SRY-box containing gene 5
chr1_+_89454769 0.607 ENSMUST00000027521.8
ENSMUST00000074945.5
Agap1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr3_-_96197580 0.601 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chr8_+_120488416 0.592 ENSMUST00000034279.9
Gse1
genetic suppressor element 1
chr5_-_107869153 0.586 ENSMUST00000128723.1
ENSMUST00000124034.1
Evi5

ecotropic viral integration site 5

chr18_+_37655891 0.586 ENSMUST00000097608.2
3222401L13Rik
RIKEN cDNA 3222401L13 gene
chr1_+_139422196 0.575 ENSMUST00000039867.7
Zbtb41
zinc finger and BTB domain containing 41 homolog
chr2_+_22622183 0.567 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr3_-_113574242 0.550 ENSMUST00000142505.2
Amy1
amylase 1, salivary
chr2_-_27463994 0.493 ENSMUST00000164296.1
Brd3
bromodomain containing 3
chr17_-_29007925 0.492 ENSMUST00000009138.5
ENSMUST00000119274.1
Stk38

serine/threonine kinase 38

chr5_-_62766153 0.477 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_-_33978751 0.460 ENSMUST00000166737.1
Zfp488
zinc finger protein 488
chr10_+_111506286 0.360 ENSMUST00000164773.1
Phlda1
pleckstrin homology-like domain, family A, member 1
chr18_+_12599894 0.347 ENSMUST00000169401.1
Ttc39c
tetratricopeptide repeat domain 39C
chr15_-_79062866 0.332 ENSMUST00000151889.1
ENSMUST00000040676.4
Ankrd54

ankyrin repeat domain 54

chr11_-_109298090 0.331 ENSMUST00000106704.2
Rgs9
regulator of G-protein signaling 9
chr9_+_75311395 0.327 ENSMUST00000076889.6
Gnb5
guanine nucleotide binding protein (G protein), beta 5
chr5_+_63812447 0.303 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr7_-_30232186 0.249 ENSMUST00000006254.5
Tbcb
tubulin folding cofactor B
chr7_+_103550368 0.244 ENSMUST00000106888.1
Olfr613
olfactory receptor 613
chr6_+_51523901 0.242 ENSMUST00000049152.8
Snx10
sorting nexin 10
chr7_+_45062429 0.236 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
Nosip



nitric oxide synthase interacting protein



chr2_+_180967291 0.220 ENSMUST00000108859.1
Arfgap1
ADP-ribosylation factor GTPase activating protein 1
chr6_+_79818031 0.214 ENSMUST00000179797.1
Gm20594
predicted gene, 20594
chr2_-_177267036 0.194 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr3_-_96905294 0.186 ENSMUST00000029738.7
Gpr89
G protein-coupled receptor 89
chr17_+_33638056 0.183 ENSMUST00000052079.7
Pram1
PML-RAR alpha-regulated adaptor molecule 1
chr19_-_7341848 0.179 ENSMUST00000171393.1
Mark2
MAP/microtubule affinity-regulating kinase 2
chr11_-_115933464 0.170 ENSMUST00000021097.3
Recql5
RecQ protein-like 5
chr7_-_130772652 0.167 ENSMUST00000057134.4
Etos1
ectopic ossification 1
chr1_-_105659008 0.161 ENSMUST00000070699.8
Pign
phosphatidylinositol glycan anchor biosynthesis, class N
chr2_-_181599128 0.149 ENSMUST00000060173.8
Samd10
sterile alpha motif domain containing 10
chr1_+_59256906 0.124 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15

cyclin-dependent kinase 15

chr9_+_64235201 0.124 ENSMUST00000039011.3
Uchl4
ubiquitin carboxyl-terminal esterase L4
chr5_+_137787769 0.122 ENSMUST00000035852.7
Zcwpw1
zinc finger, CW type with PWWP domain 1
chr9_-_107770945 0.112 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
Rbm5



RNA binding motif protein 5



chr9_+_92309362 0.105 ENSMUST00000098477.1
ENSMUST00000150594.1
1700057G04Rik

RIKEN cDNA 1700057G04 gene

chr5_+_31452427 0.100 ENSMUST00000076264.4
Zfp512
zinc finger protein 512
chr5_+_34999111 0.091 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr7_+_28693997 0.063 ENSMUST00000108280.1
Fbxo27
F-box protein 27
chr9_+_122351555 0.061 ENSMUST00000156520.1
Abhd5
abhydrolase domain containing 5
chr12_-_100159601 0.057 ENSMUST00000021596.7
Nrde2
nrde-2 necessary for RNA interference, domain containing
chr1_-_24005608 0.051 ENSMUST00000027338.3
1110058L19Rik
RIKEN cDNA 1110058L19 gene
chr5_+_34999070 0.025 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr2_-_165287755 0.013 ENSMUST00000109298.1
ENSMUST00000109299.1
ENSMUST00000130393.1
ENSMUST00000017808.7
ENSMUST00000131409.1
ENSMUST00000156134.1
ENSMUST00000133961.1
Slc35c2






solute carrier family 35, member C2






chr2_-_67433181 0.011 ENSMUST00000180773.1
Gm26727
predicted gene, 26727
chr4_-_4793275 0.011 ENSMUST00000084949.2
Impad1
inositol monophosphatase domain containing 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0019732 antifungal humoral response(GO:0019732)
0.5 2.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.4 4.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.4 3.0 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.4 1.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.3 0.9 GO:0007525 somatic muscle development(GO:0007525)
0.3 1.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 1.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.2 1.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 1.4 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 1.9 GO:0042572 retinol metabolic process(GO:0042572)
0.2 0.6 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 1.4 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.4 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 1.3 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 0.3 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.1 0.6 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 1.5 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 8.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.7 GO:0032264 IMP salvage(GO:0032264)
0.1 3.1 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 1.0 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.8 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.9 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.9 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.6 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.1 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 0.2 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.0 0.9 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.1 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 1.4 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.5 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 1.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.2 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 1.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.2 GO:0071539 protein localization to centrosome(GO:0071539)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0043512 inhibin A complex(GO:0043512)
0.4 4.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.4 1.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 3.0 GO:0031045 dense core granule(GO:0031045)
0.2 1.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.4 GO:0071439 clathrin complex(GO:0071439)
0.1 6.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 3.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.9 GO:0042101 T cell receptor complex(GO:0042101)
0.1 4.1 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.5 GO:0070688 MLL5-L complex(GO:0070688)
0.1 4.8 GO:0043195 terminal bouton(GO:0043195)
0.1 0.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.8 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 6.0 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0008061 chitin binding(GO:0008061)
0.3 4.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.3 6.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 1.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 1.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 1.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 2.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 1.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 0.6 GO:0004556 alpha-amylase activity(GO:0004556)
0.2 1.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 0.6 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2 0.6 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.1 1.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 3.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 1.2 GO:0032183 SUMO binding(GO:0032183)
0.1 0.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.9 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 5.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.5 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.2 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.0 1.8 GO:0017124 SH3 domain binding(GO:0017124)