Motif ID: Hoxb1

Z-value: 0.575


Transcription factors associated with Hoxb1:

Gene SymbolEntrez IDGene Name
Hoxb1 ENSMUSG00000018973.2 Hoxb1



Activity profile for motif Hoxb1.

activity profile for motif Hoxb1


Sorted Z-values histogram for motif Hoxb1

Sorted Z-values for motif Hoxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_73391160 4.910 ENSMUST00000128471.1
Rgma
RGM domain family, member A
chr1_-_119053339 4.500 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2


GLI-Kruppel family member GLI2


chr3_+_127633134 2.988 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr1_-_119053619 2.286 ENSMUST00000062483.8
Gli2
GLI-Kruppel family member GLI2
chr2_+_124610278 1.954 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr2_+_124610573 1.910 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr19_-_41743665 1.821 ENSMUST00000025993.3
Slit1
slit homolog 1 (Drosophila)
chrX_+_110814390 1.598 ENSMUST00000078229.3
Pou3f4
POU domain, class 3, transcription factor 4
chr1_+_127306706 1.489 ENSMUST00000171405.1
Mgat5
mannoside acetylglucosaminyltransferase 5
chr7_-_97417730 1.384 ENSMUST00000043077.7
Thrsp
thyroid hormone responsive
chrX_+_166344692 1.370 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b





glycoprotein m6b





chr3_-_88762244 1.360 ENSMUST00000183267.1
Syt11
synaptotagmin XI
chr14_-_69284982 1.326 ENSMUST00000183882.1
ENSMUST00000037064.4
Slc25a37

solute carrier family 25, member 37

chr14_-_69503220 1.164 ENSMUST00000180059.2
Gm21464
predicted gene, 21464
chr1_+_178798438 1.109 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr4_+_103114712 0.905 ENSMUST00000143417.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr12_+_38780284 0.903 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr1_-_135688094 0.900 ENSMUST00000112103.1
Nav1
neuron navigator 1
chr15_+_74516196 0.891 ENSMUST00000042035.9
Bai1
brain-specific angiogenesis inhibitor 1
chr10_+_127677064 0.889 ENSMUST00000118612.1
ENSMUST00000048099.4
Tmem194

transmembrane protein 194

chr4_-_91399984 0.888 ENSMUST00000102799.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_-_78577771 0.875 ENSMUST00000039438.7
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr1_-_157412576 0.842 ENSMUST00000078308.6
ENSMUST00000139470.1
Rasal2

RAS protein activator like 2

chr9_+_65890237 0.759 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr10_-_88605017 0.758 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr2_+_84840612 0.736 ENSMUST00000111625.1
Slc43a1
solute carrier family 43, member 1
chr4_-_103114238 0.728 ENSMUST00000036451.8
ENSMUST00000036557.8
Wdr78

WD repeat domain 78

chr4_-_103114555 0.691 ENSMUST00000106868.3
Wdr78
WD repeat domain 78
chr10_+_4266323 0.652 ENSMUST00000045730.5
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr9_-_91365778 0.588 ENSMUST00000065360.3
Zic1
zinc finger protein of the cerebellum 1
chr18_-_56562187 0.580 ENSMUST00000171844.2
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr12_-_15816762 0.562 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr3_+_41564880 0.540 ENSMUST00000168086.1
Phf17
PHD finger protein 17
chr18_-_56562215 0.539 ENSMUST00000170309.1
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr9_-_91365756 0.521 ENSMUST00000034927.6
Zic1
zinc finger protein of the cerebellum 1
chr4_+_118428078 0.515 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr5_+_19907774 0.511 ENSMUST00000115267.2
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_+_67185730 0.487 ENSMUST00000173689.1
Jmjd1c
jumonji domain containing 1C
chr1_-_45503282 0.456 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr4_+_103114385 0.444 ENSMUST00000106858.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr8_-_117673682 0.438 ENSMUST00000173522.1
ENSMUST00000174450.1
Sdr42e1

short chain dehydrogenase/reductase family 42E, member 1

chr10_-_92162753 0.416 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr18_-_56562261 0.359 ENSMUST00000066208.6
ENSMUST00000172734.1
Aldh7a1

aldehyde dehydrogenase family 7, member A1

chr3_-_58525867 0.336 ENSMUST00000029385.7
Serp1
stress-associated endoplasmic reticulum protein 1
chr8_-_8639363 0.333 ENSMUST00000152698.1
Efnb2
ephrin B2
chrX_+_143518671 0.332 ENSMUST00000134402.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr8_-_87959560 0.287 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr9_-_13245741 0.285 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr2_+_119972699 0.260 ENSMUST00000066058.7
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr8_+_25808474 0.232 ENSMUST00000033979.4
Star
steroidogenic acute regulatory protein
chr4_+_43669610 0.229 ENSMUST00000107866.1
Tmem8b
transmembrane protein 8B
chr10_-_127666673 0.193 ENSMUST00000026469.2
Nab2
Ngfi-A binding protein 2
chr10_-_63421739 0.184 ENSMUST00000054760.4
Gm7075
predicted gene 7075
chr11_+_75486813 0.173 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
Prpf8


pre-mRNA processing factor 8


chr7_+_119690026 0.154 ENSMUST00000047045.8
Acsm4
acyl-CoA synthetase medium-chain family member 4
chr8_+_84901928 0.126 ENSMUST00000067060.7
Klf1
Kruppel-like factor 1 (erythroid)
chr8_-_83458386 0.121 ENSMUST00000081506.3
Scoc
short coiled-coil protein
chr7_+_48789003 0.114 ENSMUST00000118927.1
ENSMUST00000125280.1
Zdhhc13

zinc finger, DHHC domain containing 13

chr3_+_58526303 0.105 ENSMUST00000138848.1
Eif2a
eukaryotic translation initiation factor 2A
chr10_-_127666598 0.101 ENSMUST00000099157.3
Nab2
Ngfi-A binding protein 2
chr16_-_56024628 0.089 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp

PEST proteolytic signal containing nuclear protein

chr18_+_42511496 0.089 ENSMUST00000025375.7
Tcerg1
transcription elongation regulator 1 (CA150)
chr9_-_108083330 0.074 ENSMUST00000159372.1
ENSMUST00000160249.1
Rnf123

ring finger protein 123

chr2_-_91070283 0.056 ENSMUST00000111436.2
ENSMUST00000073575.5
Slc39a13

solute carrier family 39 (metal ion transporter), member 13

chr4_-_63662910 0.052 ENSMUST00000184252.1
Gm11214
predicted gene 11214
chr3_-_65958236 0.052 ENSMUST00000029416.7
Ccnl1
cyclin L1
chr16_-_97962581 0.046 ENSMUST00000113734.2
ENSMUST00000052089.7
ENSMUST00000063605.7
Zbtb21


zinc finger and BTB domain containing 21


chr17_+_29490812 0.043 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr11_-_83298873 0.040 ENSMUST00000175741.1
ENSMUST00000176518.1
Pex12

peroxisomal biogenesis factor 12


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:0060032 notochord regression(GO:0060032)
0.5 4.9 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.5 1.4 GO:1905154 negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154)
0.4 0.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.4 1.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.3 1.8 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.2 1.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.2 1.6 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.2 0.5 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 3.9 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 1.3 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.1 0.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.5 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.8 GO:0019985 translesion synthesis(GO:0019985)
0.1 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.4 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.1 0.6 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 1.4 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.0 0.5 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.3 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.3 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.3 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 3.0 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.3 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 1.5 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.6 GO:0007628 adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0 0.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.6 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.8 GO:0097542 ciliary tip(GO:0097542)
0.2 1.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 0.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 4.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.0 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.9 GO:1990459 transferrin receptor binding(GO:1990459)
0.4 1.5 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.3 1.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 1.8 GO:0048495 Roundabout binding(GO:0048495)
0.2 0.9 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 1.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 3.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 3.0 GO:0070888 E-box binding(GO:0070888)
0.1 0.2 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.5 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.7 GO:0008179 adenylate cyclase binding(GO:0008179) receptor signaling complex scaffold activity(GO:0030159)
0.0 1.4 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 7.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.2 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)