Motif ID: Hoxb5

Z-value: 1.025


Transcription factors associated with Hoxb5:

Gene SymbolEntrez IDGene Name
Hoxb5 ENSMUSG00000038700.3 Hoxb5



Activity profile for motif Hoxb5.

activity profile for motif Hoxb5


Sorted Z-values histogram for motif Hoxb5

Sorted Z-values for motif Hoxb5



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_125532377 15.114 ENSMUST00000031446.6
 Tmem132b
transmembrane protein 132B
chr6_-_18514802 12.167 ENSMUST00000090601.5
 Cttnbp2
cortactin binding protein 2
chr17_-_57087729 10.283 ENSMUST00000071135.5
 Tubb4a
tubulin, beta 4A class IVA
chr1_-_56971762 9.305 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr17_+_35076902 7.847 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr12_-_78980758 7.839 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chrX_-_165327376 7.004 ENSMUST00000058787.8
 Glra2
glycine receptor, alpha 2 subunit
chr12_-_78983476 6.880 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr11_+_74619594 6.420 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr17_+_35077080 6.249 ENSMUST00000172959.1
 Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr2_+_158667119 5.861 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr13_+_88821472 5.764 ENSMUST00000118731.1
ENSMUST00000081769.6
 Edil3

EGF-like repeats and discoidin I-like domains 3

chr13_+_88821606 5.339 ENSMUST00000043111.6
 Edil3
EGF-like repeats and discoidin I-like domains 3
chr10_-_62143906 5.154 ENSMUST00000141724.1
ENSMUST00000150057.1
 2010107G23Rik

RIKEN cDNA 2010107G23 gene

chr3_-_85722474 4.975 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr3_-_89160155 4.367 ENSMUST00000029686.3
 Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr5_+_117133567 4.341 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr2_-_153225396 4.328 ENSMUST00000099194.2
 Tspyl3
TSPY-like 3
chr7_+_3390629 4.145 ENSMUST00000182222.1
 Cacng8
calcium channel, voltage-dependent, gamma subunit 8
chr19_-_45816007 3.747 ENSMUST00000079431.3
ENSMUST00000026247.6
ENSMUST00000162528.2
 Kcnip2


Kv channel-interacting protein 2


chr10_-_81014902 3.576 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
 Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr10_+_80300997 3.447 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2

chr7_-_31150981 3.102 ENSMUST00000085636.6
ENSMUST00000001280.7
 Gramd1a

GRAM domain containing 1A

chr11_+_97798995 2.997 ENSMUST00000143571.1
 Lasp1
LIM and SH3 protein 1
chr5_-_103211251 2.638 ENSMUST00000060871.5
ENSMUST00000112846.1
ENSMUST00000170792.1
ENSMUST00000112847.2
 Mapk10



mitogen-activated protein kinase 10



chr7_+_19004047 2.606 ENSMUST00000053713.3
 Irf2bp1
interferon regulatory factor 2 binding protein 1
chr16_+_17070127 2.565 ENSMUST00000115729.1
 Ypel1
yippee-like 1 (Drosophila)
chr15_-_28025834 2.500 ENSMUST00000090247.5
 Trio
triple functional domain (PTPRF interacting)
chr9_-_35558522 2.414 ENSMUST00000034612.5
 Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chrX_+_7723278 2.366 ENSMUST00000144148.1
 Wdr45
WD repeat domain 45
chr9_+_20581296 2.348 ENSMUST00000115557.2
 Zfp846
zinc finger protein 846
chr11_+_4873951 2.294 ENSMUST00000038570.2
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr16_+_17070220 2.201 ENSMUST00000141959.1
 Ypel1
yippee-like 1 (Drosophila)
chr1_-_193370260 2.158 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr7_+_119895836 2.147 ENSMUST00000106518.1
ENSMUST00000054440.3
 Lyrm1

LYR motif containing 1

chr1_-_193370225 2.066 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr8_-_25597459 2.036 ENSMUST00000079160.6
 Letm2
leucine zipper-EF-hand containing transmembrane protein 2
chr10_-_127211528 1.984 ENSMUST00000013970.7
 Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr17_+_31386244 1.964 ENSMUST00000134525.1
ENSMUST00000127929.1
 Pde9a

phosphodiesterase 9A

chr7_+_16875302 1.934 ENSMUST00000108493.1
 Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr7_-_119895697 1.929 ENSMUST00000059851.6
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr17_+_31386218 1.871 ENSMUST00000047168.5
 Pde9a
phosphodiesterase 9A
chr8_+_95081187 1.855 ENSMUST00000034239.7
 Katnb1
katanin p80 (WD40-containing) subunit B 1
chr7_-_100964371 1.823 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr11_-_96075655 1.769 ENSMUST00000090541.5
 Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr5_+_143933059 1.718 ENSMUST00000166847.1
 Rsph10b
radial spoke head 10 homolog B (Chlamydomonas)
chr14_+_55560010 1.700 ENSMUST00000147981.1
ENSMUST00000133256.1
 Dcaf11

DDB1 and CUL4 associated factor 11

chr7_-_133708958 1.664 ENSMUST00000106146.1
 Uros
uroporphyrinogen III synthase
chr6_-_113501818 1.618 ENSMUST00000101059.1
 Prrt3
proline-rich transmembrane protein 3
chr2_-_167062607 1.593 ENSMUST00000128676.1
 Znfx1
zinc finger, NFX1-type containing 1
chr14_+_32159865 1.584 ENSMUST00000163336.1
ENSMUST00000169722.1
ENSMUST00000168385.1
 Ncoa4


nuclear receptor coactivator 4


chr14_+_55559993 1.560 ENSMUST00000117236.1
 Dcaf11
DDB1 and CUL4 associated factor 11
chr14_-_63543931 1.548 ENSMUST00000058679.5
 Mtmr9
myotubularin related protein 9
chr7_-_133709069 1.537 ENSMUST00000106145.3
 Uros
uroporphyrinogen III synthase
chr7_-_133709051 1.506 ENSMUST00000124759.1
ENSMUST00000106144.1
 Uros

uroporphyrinogen III synthase

chr8_-_85840877 1.469 ENSMUST00000034140.7
 Itfg1
integrin alpha FG-GAP repeat containing 1
chr8_+_123332676 1.428 ENSMUST00000010298.6
 Spire2
spire homolog 2 (Drosophila)
chr7_+_119896292 1.348 ENSMUST00000106517.1
 Lyrm1
LYR motif containing 1
chr2_-_116065798 1.314 ENSMUST00000110907.1
ENSMUST00000110908.2
 Meis2

Meis homeobox 2

chr11_-_96075581 1.310 ENSMUST00000107686.1
ENSMUST00000107684.1
 Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr10_-_88683021 1.305 ENSMUST00000004473.8
 Spic
Spi-C transcription factor (Spi-1/PU.1 related)
chr7_-_123500449 1.295 ENSMUST00000042470.7
ENSMUST00000128217.1
 Zkscan2

zinc finger with KRAB and SCAN domains 2

chr4_-_52497244 1.220 ENSMUST00000114578.4
 Vma21-ps
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene
chr16_+_17070281 1.186 ENSMUST00000090199.3
 Ypel1
yippee-like 1 (Drosophila)
chr7_-_109083284 1.056 ENSMUST00000120876.1
ENSMUST00000055993.6
 Ric3

resistance to inhibitors of cholinesterase 3 homolog (C. elegans)

chr6_+_86438360 0.993 ENSMUST00000050497.7
 C87436
expressed sequence C87436
chr7_-_119896285 0.973 ENSMUST00000106519.1
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr14_-_41004517 0.906 ENSMUST00000153830.1
 Fam213a
family with sequence similarity 213, member A
chr10_+_21882184 0.836 ENSMUST00000120509.1
 Sgk1
serum/glucocorticoid regulated kinase 1
chr17_-_47691403 0.823 ENSMUST00000113299.1
ENSMUST00000152214.1
 Gm21981
Prickle4
predicted gene 21981
prickle homolog 4 (Drosophila)
chrX_+_7822289 0.817 ENSMUST00000009875.4
 Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr3_-_103737995 0.796 ENSMUST00000029440.8
 Olfml3
olfactomedin-like 3
chr7_-_127208423 0.781 ENSMUST00000120705.1
 Tbc1d10b
TBC1 domain family, member 10b
chr4_+_11704439 0.754 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr7_-_45466894 0.691 ENSMUST00000033093.8
 Bax
BCL2-associated X protein
chr2_+_26973416 0.613 ENSMUST00000014996.7
ENSMUST00000102891.3
 Adamts13

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

chr4_-_108848619 0.565 ENSMUST00000164855.1
 A730015C16Rik
RIKEN cDNA A730015C16 gene
chr10_-_63927434 0.541 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr5_-_114273702 0.515 ENSMUST00000144050.1
ENSMUST00000044790.5
 Foxn4

forkhead box N4

chr17_+_94873986 0.509 ENSMUST00000108007.4
 Gm20939
predicted gene, 20939
chr6_+_141249161 0.503 ENSMUST00000043259.7
 Pde3a
phosphodiesterase 3A, cGMP inhibited
chr1_-_166409773 0.501 ENSMUST00000135673.1
ENSMUST00000079972.6
ENSMUST00000169324.1
ENSMUST00000111411.2
ENSMUST00000128861.1
 Pogk




pogo transposable element with KRAB domain




chr2_+_116067933 0.483 ENSMUST00000156095.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr4_+_86053887 0.444 ENSMUST00000107178.2
ENSMUST00000048885.5
ENSMUST00000141889.1
ENSMUST00000120678.1
 Adamtsl1



ADAMTS-like 1



chr12_-_36042476 0.333 ENSMUST00000020896.8
 Tspan13
tetraspanin 13
chr8_+_70594466 0.310 ENSMUST00000019283.9
 Isyna1
myo-inositol 1-phosphate synthase A1
chr13_+_14063776 0.294 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
 Arid4b




AT rich interactive domain 4B (RBP1-like)




chr7_+_25627604 0.280 ENSMUST00000076034.6
 B3gnt8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr12_+_116275386 0.058 ENSMUST00000090195.4
 Gm11027
predicted gene 11027
chr17_+_57105385 0.024 ENSMUST00000039490.7
 Tnfsf9
tumor necrosis factor (ligand) superfamily, member 9
chrX_-_134111852 0.019 ENSMUST00000033610.6
 Nox1
NADPH oxidase 1
chr9_-_35116804 0.015 ENSMUST00000034537.6
 St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.9 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
1.2 4.7 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
1.0 7.0 GO:0071361 cellular response to zinc ion(GO:0071294) cellular response to ethanol(GO:0071361)
0.7 3.7 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.6 1.9 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.6 1.8 GO:0030321 transepithelial chloride transport(GO:0030321)
0.6 9.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 14.1 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.5 1.4 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.4 2.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.4 3.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.3 5.4 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.2 0.7 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.2 4.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 2.0 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.2 3.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 2.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 2.9 GO:0010225 response to UV-C(GO:0010225)
0.2 0.5 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 4.1 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 3.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 11.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.1 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 0.8 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 4.4 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 2.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 1.3 GO:0008542 visual learning(GO:0008542)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 2.3 GO:0019233 sensory perception of pain(GO:0019233)
0.0 2.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.0 GO:0045852 regulation of integrin biosynthetic process(GO:0045113) pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.8 GO:0051310 metaphase plate congression(GO:0051310)
0.0 0.9 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 8.7 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.0 1.3 GO:0001824 blastocyst development(GO:0001824)
0.0 7.4 GO:0007017 microtubule-based process(GO:0007017)
0.0 0.8 GO:0090630 activation of GTPase activity(GO:0090630)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 10.3 GO:0033269 internode region of axon(GO:0033269)
0.9 4.4 GO:0044316 cone cell pedicle(GO:0044316)
0.3 3.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 2.4 GO:0033391 chromatoid body(GO:0033391)
0.3 3.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 2.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 5.9 GO:0034707 chloride channel complex(GO:0034707)
0.1 3.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 4.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 9.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 3.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 4.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 6.5 GO:0043204 perikaryon(GO:0043204)
0.1 9.4 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0051233 spindle midzone(GO:0051233)
0.0 2.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.9 GO:0030496 midbody(GO:0030496)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 1.0 GO:0005776 autophagosome(GO:0005776)
0.0 7.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.1 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
2.3 7.0 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
1.5 12.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.9 4.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.9 4.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.8 4.7 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.7 2.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.3 5.9 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 1.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 3.8 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2 1.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 1.9 GO:0070097 delta-catenin binding(GO:0070097)
0.2 2.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 3.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.9 GO:0097602 cullin family protein binding(GO:0097602)
0.1 10.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.8 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 11.1 GO:0005178 integrin binding(GO:0005178)
0.1 2.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.3 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 2.3 GO:0042165 neurotransmitter binding(GO:0042165)
0.1 0.7 GO:0051434 BH3 domain binding(GO:0051434)
0.1 1.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 2.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.4 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 3.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 2.0 GO:0043022 ribosome binding(GO:0043022)
0.0 4.5 GO:0016247 channel regulator activity(GO:0016247)
0.0 3.0 GO:0051015 actin filament binding(GO:0051015)
0.0 2.2 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0030552 cAMP binding(GO:0030552)
0.0 0.9 GO:0016209 antioxidant activity(GO:0016209)