Motif ID: Hoxb6

Z-value: 0.365


Transcription factors associated with Hoxb6:

Gene SymbolEntrez IDGene Name
Hoxb6 ENSMUSG00000000690.4 Hoxb6



Activity profile for motif Hoxb6.

activity profile for motif Hoxb6


Sorted Z-values histogram for motif Hoxb6

Sorted Z-values for motif Hoxb6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_85127514 2.795 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr10_-_58675631 2.558 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chr12_-_119238794 2.373 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr19_+_25406661 1.340 ENSMUST00000146647.1
 Kank1
KN motif and ankyrin repeat domains 1
chr8_-_105471481 1.215 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr8_+_13435459 1.153 ENSMUST00000167071.1
ENSMUST00000167505.1
 Tmem255b

transmembrane protein 255B

chr11_-_69795930 0.920 ENSMUST00000045971.8
 Chrnb1
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
chr2_+_164769892 0.812 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr6_-_12109583 0.806 ENSMUST00000080891.5
 Gm6578
predicted gene 6578
chr7_+_113207465 0.804 ENSMUST00000047321.7
 Arntl
aryl hydrocarbon receptor nuclear translocator-like
chr10_-_64090265 0.800 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_-_94412883 0.737 ENSMUST00000181305.1
 1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr3_-_116712644 0.726 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr19_-_6925367 0.621 ENSMUST00000057716.4
 Tex40
testis expressed 40
chr2_-_125859139 0.598 ENSMUST00000110463.1
ENSMUST00000028635.5
 Cops2

COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)

chr9_-_70141484 0.583 ENSMUST00000034749.8
 Fam81a
family with sequence similarity 81, member A
chr4_+_15881255 0.526 ENSMUST00000029876.1
 Calb1
calbindin 1
chr3_+_66985647 0.505 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_94413244 0.431 ENSMUST00000166032.1
ENSMUST00000045245.5
 Tdrkh

tudor and KH domain containing protein

chr3_+_66985680 0.401 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr11_-_72215592 0.385 ENSMUST00000021157.8
 Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr7_+_51880312 0.327 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chr8_-_77610597 0.323 ENSMUST00000034030.8
 Tmem184c
transmembrane protein 184C
chr8_-_77610668 0.311 ENSMUST00000141202.1
ENSMUST00000152168.1
 Tmem184c

transmembrane protein 184C

chr15_+_34306666 0.307 ENSMUST00000163455.2
ENSMUST00000022947.5
 Matn2

matrilin 2

chr9_+_96258697 0.306 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr4_-_138326234 0.289 ENSMUST00000105817.3
ENSMUST00000030536.6
 Pink1

PTEN induced putative kinase 1

chr11_-_74724670 0.287 ENSMUST00000021091.8
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr3_+_68572245 0.273 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr3_-_100969644 0.269 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chr6_-_3494587 0.255 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr3_-_119783262 0.238 ENSMUST00000029780.7
 Ptbp2
polypyrimidine tract binding protein 2
chr1_-_45503282 0.231 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr19_-_40402267 0.179 ENSMUST00000099467.3
ENSMUST00000099466.3
ENSMUST00000165212.1
ENSMUST00000165469.1
 Sorbs1



sorbin and SH3 domain containing 1



chr1_-_22805994 0.150 ENSMUST00000097808.4
 Rims1
regulating synaptic membrane exocytosis 1
chr14_+_32599922 0.149 ENSMUST00000068938.5
 Prrxl1
paired related homeobox protein-like 1
chr9_-_35570393 0.147 ENSMUST00000115110.4
 Hyls1
hydrolethalus syndrome 1
chr16_+_44347121 0.119 ENSMUST00000050897.6
 Spice1
spindle and centriole associated protein 1
chr10_-_39122277 0.062 ENSMUST00000136546.1
 Fam229b
family with sequence similarity 229, member B
chr9_+_92309362 0.058 ENSMUST00000098477.1
ENSMUST00000150594.1
 1700057G04Rik

RIKEN cDNA 1700057G04 gene

chr13_+_93304066 0.047 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr10_+_72309225 0.047 ENSMUST00000061324.4
 Gm9923
predicted pseudogene 9923
chr14_+_118137101 0.044 ENSMUST00000022728.2
 Gpr180
G protein-coupled receptor 180
chrX_-_101222426 0.043 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
 Snx12


sorting nexin 12


chr13_+_58281183 0.027 ENSMUST00000180882.1
ENSMUST00000180452.1
 Gm26555

predicted gene, 26555


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.3 2.6 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.3 0.8 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.2 0.8 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.7 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.9 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.3 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.1 2.4 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661) regulation of microtubule motor activity(GO:2000574)
0.1 0.8 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0 0.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.9 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.5 GO:0007614 short-term memory(GO:0007614)
0.0 0.3 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 1.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.3 GO:0001553 luteinization(GO:0001553)
0.0 0.0 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.1 GO:0021559 trigeminal nerve development(GO:0021559)
0.0 0.4 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.8 GO:0033391 chromatoid body(GO:0033391)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.4 GO:0070847 core mediator complex(GO:0070847)
0.1 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.3 GO:0000235 astral microtubule(GO:0000235)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.6 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.9 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)