Motif ID: Hoxb7

Z-value: 4.319


Transcription factors associated with Hoxb7:

Gene SymbolEntrez IDGene Name
Hoxb7 ENSMUSG00000038721.8 Hoxb7



Activity profile for motif Hoxb7.

activity profile for motif Hoxb7


Sorted Z-values histogram for motif Hoxb7

Sorted Z-values for motif Hoxb7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_55681257 77.843 ENSMUST00000044767.8
 Neurod6
neurogenic differentiation 6
chr13_+_83504032 74.207 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_+_19103022 66.679 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr8_+_54954728 62.823 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr16_+_7069825 61.060 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_+_18054258 57.431 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr1_+_177445660 55.490 ENSMUST00000077225.6
 Zbtb18
zinc finger and BTB domain containing 18
chr8_-_84773381 52.555 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr5_+_117841839 50.360 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr12_+_29528382 49.771 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr3_+_55461758 49.478 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr15_+_21111452 48.072 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr1_-_56969864 47.868 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr17_+_3397189 47.812 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr1_-_56969827 47.601 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_13751297 47.246 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_13839916 46.874 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr19_+_26605106 46.687 ENSMUST00000025862.7
ENSMUST00000176030.1
 Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr11_+_77930800 46.068 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr8_-_109251698 45.434 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 399 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.7 238.7 GO:0006376 mRNA splice site selection(GO:0006376)
10.6 170.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
5.1 164.0 GO:0060074 synapse maturation(GO:0060074)
11.0 121.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
13.3 120.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
3.3 106.6 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
2.8 101.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
4.5 99.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
15.9 95.6 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
7.2 94.0 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
1.2 93.1 GO:0001578 microtubule bundle formation(GO:0001578)
30.0 90.0 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
17.1 85.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
9.4 84.4 GO:0071420 cellular response to histamine(GO:0071420)
10.2 81.7 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.9 80.0 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
12.3 74.1 GO:0072318 clathrin coat disassembly(GO:0072318)
4.9 73.7 GO:0021860 pyramidal neuron development(GO:0021860)
5.1 66.9 GO:0097090 presynaptic membrane organization(GO:0097090)
1.1 65.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 307.1 GO:0045211 postsynaptic membrane(GO:0045211)
1.3 269.2 GO:0060076 excitatory synapse(GO:0060076)
1.4 143.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 132.3 GO:0016021 integral component of membrane(GO:0016021)
0.2 125.4 GO:0005768 endosome(GO:0005768)
2.9 125.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
6.1 122.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 121.7 GO:0045202 synapse(GO:0045202)
6.3 120.1 GO:0071564 npBAF complex(GO:0071564)
6.9 110.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
1.9 97.1 GO:0045171 intercellular bridge(GO:0045171)
3.1 95.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
6.0 89.9 GO:0031045 dense core granule(GO:0031045)
4.8 86.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
9.5 85.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
3.9 77.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.4 74.7 GO:0016604 nuclear body(GO:0016604)
6.6 72.1 GO:0043083 synaptic cleft(GO:0043083)
0.5 71.6 GO:0016607 nuclear speck(GO:0016607)
2.0 70.8 GO:0042734 presynaptic membrane(GO:0042734)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 239 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 174.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.1 150.7 GO:0005057 receptor signaling protein activity(GO:0005057)
0.8 138.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 137.3 GO:0044822 poly(A) RNA binding(GO:0044822)
5.4 124.4 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
6.3 106.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
3.6 105.1 GO:0001786 phosphatidylserine binding(GO:0001786)
2.0 99.8 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
11.9 95.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
3.1 93.9 GO:0070412 R-SMAD binding(GO:0070412)
0.4 93.4 GO:0008017 microtubule binding(GO:0008017)
1.2 92.1 GO:0005262 calcium channel activity(GO:0005262)
0.8 89.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
4.8 86.1 GO:0004890 GABA-A receptor activity(GO:0004890)
12.9 77.6 GO:0070699 type II activin receptor binding(GO:0070699)
2.9 69.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.2 65.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
5.0 65.0 GO:0004385 guanylate kinase activity(GO:0004385)
5.9 64.8 GO:0003680 AT DNA binding(GO:0003680)
5.8 63.6 GO:0038191 neuropilin binding(GO:0038191)