Motif ID: Hoxc4_Arx_Otp_Esx1_Phox2b

Z-value: 0.594

Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b:

Gene SymbolEntrez IDGene Name
Arx ENSMUSG00000035277.9 Arx
Esx1 ENSMUSG00000023443.7 Esx1
Hoxc4 ENSMUSG00000075394.3 Hoxc4
Otp ENSMUSG00000021685.10 Otp
Phox2b ENSMUSG00000012520.8 Phox2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otpmm10_v2_chr13_+_94875600_94875611-0.172.0e-01Click!
Arxmm10_v2_chrX_+_93286499_932865220.133.2e-01Click!


Activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b.

activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b


Sorted Z-values histogram for motif Hoxc4_Arx_Otp_Esx1_Phox2b

Sorted Z-values for motif Hoxc4_Arx_Otp_Esx1_Phox2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc4_Arx_Otp_Esx1_Phox2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_105789869 8.065 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr17_+_82539258 2.961 ENSMUST00000097278.3
 Gm6594
predicted pseudogene 6594
chr17_-_48432723 2.421 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr14_+_58893465 2.326 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr4_+_145585166 2.197 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr2_+_20737306 2.004 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr4_-_14621805 1.978 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr12_-_84617326 1.680 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr4_+_145510759 1.591 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr5_-_62766153 1.279 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_-_5863663 1.132 ENSMUST00000178594.1
 Gm8237
predicted gene 8237
chr3_+_28263205 1.036 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr10_-_37138863 1.029 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr14_+_4198185 0.961 ENSMUST00000180184.1
 Gm2974
predicted gene 2974
chrM_+_10167 0.924 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr13_+_23533869 0.854 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr2_-_73580288 0.852 ENSMUST00000028515.3
 Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr5_+_13398688 0.818 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr14_+_57524734 0.771 ENSMUST00000089494.4
 Il17d
interleukin 17D
chr10_-_86022325 0.770 ENSMUST00000181665.1
 A230060F14Rik
RIKEN cDNA A230060F14 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.7 GO:0019532 oxalate transport(GO:0019532)
0.1 2.4 GO:0080111 DNA demethylation(GO:0080111)
0.3 1.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 1.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 1.0 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.9 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 0.8 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.2 0.7 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749)
0.1 0.7 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.7 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.7 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.6 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.0 0.6 GO:0006953 acute-phase response(GO:0006953)
0.0 0.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.2 0.5 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.5 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.1 0.5 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0070469 respiratory chain(GO:0070469)
0.0 1.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 1.0 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 0.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.5 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.3 GO:0043205 fibril(GO:0043205)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.1 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 2.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.6 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.0 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.9 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.1 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.7 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 0.6 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 0.5 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.2 0.5 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.5 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.5 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 0.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.4 GO:0017134 fibroblast growth factor binding(GO:0017134)