Motif ID: Hoxc6

Z-value: 0.313


Transcription factors associated with Hoxc6:

Gene SymbolEntrez IDGene Name
Hoxc6 ENSMUSG00000001661.4 Hoxc6



Activity profile for motif Hoxc6.

activity profile for motif Hoxc6


Sorted Z-values histogram for motif Hoxc6

Sorted Z-values for motif Hoxc6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_143933204 1.910 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 1.593 ENSMUST00000087313.3
 Dcx
doublecortin
chr11_-_26210553 1.577 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr1_-_22315792 1.010 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr3_+_5218546 0.827 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr3_+_5218516 0.818 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr6_-_65144908 0.771 ENSMUST00000031982.4
 Hpgds
hematopoietic prostaglandin D synthase
chr2_+_65620829 0.756 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr8_-_54724317 0.752 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
 Wdr17


WD repeat domain 17


chr3_+_5218589 0.658 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr10_-_100589205 0.656 ENSMUST00000054471.8
 4930430F08Rik
RIKEN cDNA 4930430F08 gene
chr5_+_17574268 0.634 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_+_19208914 0.542 ENSMUST00000027059.4
 Tfap2b
transcription factor AP-2 beta
chr8_-_9976294 0.528 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chr6_+_128399766 0.472 ENSMUST00000001561.5
 Nrip2
nuclear receptor interacting protein 2
chr7_+_123123870 0.460 ENSMUST00000094053.5
 Tnrc6a
trinucleotide repeat containing 6a
chr11_-_23895208 0.448 ENSMUST00000102863.2
ENSMUST00000020513.3
 Papolg

poly(A) polymerase gamma

chr10_-_53647080 0.430 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr19_+_11469353 0.429 ENSMUST00000165310.1
 Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C
chr3_-_113574242 0.419 ENSMUST00000142505.2
 Amy1
amylase 1, salivary
chr2_-_51149100 0.411 ENSMUST00000154545.1
ENSMUST00000017288.2
 Rnd3

Rho family GTPase 3

chrM_+_14138 0.409 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr6_+_128399881 0.394 ENSMUST00000120405.1
 Nrip2
nuclear receptor interacting protein 2
chr3_+_129213920 0.371 ENSMUST00000042587.10
 Pitx2
paired-like homeodomain transcription factor 2
chr7_+_5020376 0.358 ENSMUST00000076251.4
 Zfp865
zinc finger protein 865
chr3_+_66985680 0.336 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr16_-_21995478 0.328 ENSMUST00000074230.4
ENSMUST00000060673.6
 Liph

lipase, member H

chr8_-_54724474 0.320 ENSMUST00000175915.1
 Wdr17
WD repeat domain 17
chr3_+_136670076 0.314 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr13_+_93304799 0.283 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr7_+_73740277 0.275 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr19_+_26748268 0.275 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
 Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chr10_-_70655934 0.254 ENSMUST00000162144.1
ENSMUST00000162793.1
 Phyhipl

phytanoyl-CoA hydroxylase interacting protein-like

chrM_-_14060 0.248 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr18_+_37484955 0.239 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr10_+_61175206 0.224 ENSMUST00000079235.5
 Tbata
thymus, brain and testes associated
chr10_-_58718210 0.211 ENSMUST00000169859.1
 Gm17542
predicted gene, 17542
chr7_-_19604444 0.204 ENSMUST00000086041.5
 Clasrp
CLK4-associating serine/arginine rich protein
chr13_+_93304066 0.204 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr15_-_50889043 0.194 ENSMUST00000183997.1
ENSMUST00000183757.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr17_-_35115428 0.187 ENSMUST00000172854.1
ENSMUST00000062657.4
 Ly6g5b

lymphocyte antigen 6 complex, locus G5B

chr5_-_110046486 0.167 ENSMUST00000167969.1
 Gm17655
predicted gene, 17655
chr15_+_100154379 0.149 ENSMUST00000023768.6
ENSMUST00000108971.2
 Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr3_+_66985700 0.139 ENSMUST00000046542.6
ENSMUST00000162693.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr1_-_191907527 0.121 ENSMUST00000069573.5
 1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr6_-_30693676 0.109 ENSMUST00000169422.1
ENSMUST00000115131.1
ENSMUST00000115130.2
ENSMUST00000031810.8
 Cep41



centrosomal protein 41



chr7_-_24299310 0.092 ENSMUST00000145131.1
 Zfp61
zinc finger protein 61
chr3_+_66985647 0.092 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr15_+_44619551 0.089 ENSMUST00000022964.7
 Ebag9
estrogen receptor-binding fragment-associated gene 9
chrX_-_136741155 0.084 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
 Morf4l2




mortality factor 4 like 2




chr7_-_16285454 0.076 ENSMUST00000174270.1
 Ccdc9
coiled-coil domain containing 9
chr4_+_144893127 0.065 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr19_+_32619997 0.057 ENSMUST00000025833.6
 Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr5_-_128953303 0.053 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chrX_-_94212638 0.051 ENSMUST00000113922.1
 Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr5_-_23616528 0.035 ENSMUST00000088392.4
 Srpk2
serine/arginine-rich protein specific kinase 2
chr17_-_78985428 0.026 ENSMUST00000118991.1
 Prkd3
protein kinase D3
chrX_-_94212685 0.009 ENSMUST00000050328.8
 Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.2 3.5 GO:0021860 pyramidal neuron development(GO:0021860)
0.2 0.8 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.2 0.5 GO:0097274 urea homeostasis(GO:0097274)
0.2 0.8 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.3 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.4 GO:0002074 extraocular skeletal muscle development(GO:0002074) pulmonary myocardium development(GO:0003350) subthalamus development(GO:0021539) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.1 0.6 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.5 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.1 0.4 GO:0033762 response to glucagon(GO:0033762)
0.0 0.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.5 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.1 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035)
0.0 0.6 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.5 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.4 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 3.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.4 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.5 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.3 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.3 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)