Motif ID: Hoxc9

Z-value: 0.610


Transcription factors associated with Hoxc9:

Gene SymbolEntrez IDGene Name
Hoxc9 ENSMUSG00000036139.6 Hoxc9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_102977032-0.114.0e-01Click!


Activity profile for motif Hoxc9.

activity profile for motif Hoxc9


Sorted Z-values histogram for motif Hoxc9

Sorted Z-values for motif Hoxc9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_102658640 3.477 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr3_+_129199919 2.779 ENSMUST00000029657.9
ENSMUST00000106382.4
 Pitx2

paired-like homeodomain transcription factor 2

chr3_+_129199878 2.181 ENSMUST00000174661.2
 Pitx2
paired-like homeodomain transcription factor 2
chr1_+_66321708 1.854 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chrX_+_56609751 1.840 ENSMUST00000144068.1
 Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr1_+_187997821 1.787 ENSMUST00000027906.6
 Esrrg
estrogen-related receptor gamma
chr4_+_136143497 1.717 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr1_+_187997835 1.692 ENSMUST00000110938.1
 Esrrg
estrogen-related receptor gamma
chr10_+_4710119 1.679 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr2_-_26516620 1.639 ENSMUST00000132820.1
 Notch1
notch 1
chr2_+_70474923 1.589 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chrX_-_143933089 1.421 ENSMUST00000087313.3
 Dcx
doublecortin
chr8_-_105471481 1.357 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr18_+_65582239 1.252 ENSMUST00000182684.1
 Zfp532
zinc finger protein 532
chr16_-_37384915 1.209 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr7_-_139582790 1.084 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr2_-_38714491 1.037 ENSMUST00000028084.4
 Nr5a1
nuclear receptor subfamily 5, group A, member 1
chr17_-_49564262 1.009 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chrX_+_56609843 0.990 ENSMUST00000077741.5
ENSMUST00000114784.2
 Slc9a6

solute carrier family 9 (sodium/hydrogen exchanger), member 6

chr3_+_129199960 0.989 ENSMUST00000173645.2
 Pitx2
paired-like homeodomain transcription factor 2
chr8_-_120228221 0.945 ENSMUST00000183235.1
 A330074K22Rik
RIKEN cDNA A330074K22 gene
chrX_-_143933204 0.851 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr18_+_65582281 0.776 ENSMUST00000183319.1
 Zfp532
zinc finger protein 532
chr1_-_45503282 0.714 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr2_+_128967383 0.701 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr11_+_85353156 0.578 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
 Bcas3





breast carcinoma amplified sequence 3





chr12_-_15816762 0.572 ENSMUST00000020922.7
 Trib2
tribbles homolog 2 (Drosophila)
chr3_+_66985700 0.565 ENSMUST00000046542.6
ENSMUST00000162693.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_67892189 0.564 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chr13_+_94083490 0.542 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr3_+_66985647 0.539 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr4_-_91376433 0.522 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr10_-_92162753 0.506 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr18_+_65582390 0.480 ENSMUST00000169679.1
ENSMUST00000183326.1
 Zfp532

zinc finger protein 532

chr13_-_25270076 0.465 ENSMUST00000057866.6
 Nrsn1
neurensin 1
chr16_-_37384940 0.459 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr8_+_54954728 0.453 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr5_-_67427794 0.450 ENSMUST00000169190.1
 Bend4
BEN domain containing 4
chr5_+_67260696 0.375 ENSMUST00000161233.1
ENSMUST00000160352.1
 Tmem33

transmembrane protein 33

chr3_+_66985680 0.362 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr4_+_107830958 0.318 ENSMUST00000106731.2
 Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr5_+_67260565 0.306 ENSMUST00000037918.5
ENSMUST00000162543.1
 Tmem33

transmembrane protein 33

chr9_+_35423582 0.283 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr2_+_4300462 0.272 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr10_-_88605017 0.269 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr11_+_3330401 0.264 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr6_-_119388671 0.259 ENSMUST00000169744.1
 Adipor2
adiponectin receptor 2
chrX_-_141474034 0.246 ENSMUST00000101205.2
 Col4a6
collagen, type IV, alpha 6
chr11_-_94242701 0.242 ENSMUST00000061469.3
 Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr2_-_84650760 0.242 ENSMUST00000111691.1
 Ctnnd1
catenin (cadherin associated protein), delta 1
chrX_-_103186618 0.241 ENSMUST00000121720.1
 Nap1l2
nucleosome assembly protein 1-like 2
chrX_-_37104523 0.224 ENSMUST00000130324.1
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr4_-_91376490 0.211 ENSMUST00000107124.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr2_-_84650714 0.193 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
 Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr9_-_7835255 0.173 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr10_-_67912620 0.156 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr15_+_8968389 0.138 ENSMUST00000053308.9
ENSMUST00000166524.1
 Ranbp3l

RAN binding protein 3-like

chr4_+_100776664 0.111 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr10_+_69925954 0.098 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr10_-_13324160 0.097 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr6_+_54269135 0.085 ENSMUST00000114401.1
 Chn2
chimerin (chimaerin) 2
chr2_-_84650676 0.081 ENSMUST00000067232.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr11_-_98022594 0.073 ENSMUST00000103144.3
ENSMUST00000017552.6
ENSMUST00000092736.4
ENSMUST00000107562.1
 Cacnb1



calcium channel, voltage-dependent, beta 1 subunit



chr13_-_78197815 0.067 ENSMUST00000127137.2
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr11_-_72215592 0.056 ENSMUST00000021157.8
 Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr2_-_84650490 0.050 ENSMUST00000066177.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr5_-_44101668 0.039 ENSMUST00000087441.4
ENSMUST00000074113.6
 Prom1

prominin 1

chr17_+_24426676 0.032 ENSMUST00000024946.5
 Eci1
enoyl-Coenzyme A delta isomerase 1
chr4_-_150003130 0.023 ENSMUST00000084117.6
 H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr9_-_89705017 0.021 ENSMUST00000058488.6
 Tmed3
transmembrane emp24 domain containing 3
chr1_+_58210397 0.011 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr2_-_128967725 0.007 ENSMUST00000099385.2
 Gm10762
predicted gene 10762

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.9 GO:0002074 extraocular skeletal muscle development(GO:0002074) pulmonary myocardium development(GO:0003350) subthalamus development(GO:0021539) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.6 3.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.5 1.6 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.4 1.7 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.4 2.8 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.3 1.0 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.2 0.7 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 0.7 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.2 1.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 2.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.6 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.1 0.3 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 1.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 3.3 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 1.6 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 0.2 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 0.6 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.1 0.2 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.0 1.5 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.2 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.3 GO:0061042 vascular wound healing(GO:0061042)
0.0 0.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 2.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.7 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 1.0 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.0 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0044308 axonal spine(GO:0044308)
0.3 1.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 0.7 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 2.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 3.5 GO:0030673 axolemma(GO:0030673)
0.1 0.6 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.7 GO:0031201 SNARE complex(GO:0031201)
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.0 GO:0071914 prominosome(GO:0071914)
0.0 0.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.5 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 1.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 2.8 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.2 1.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 0.6 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.2 3.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 5.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.6 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 2.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.3 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.3 GO:0038025 reelin receptor activity(GO:0038025)
0.1 0.3 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.0 1.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.1 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.7 GO:0019905 syntaxin binding(GO:0019905)