Motif ID: Hoxd11_Cdx1_Hoxc11

Z-value: 0.706

Transcription factors associated with Hoxd11_Cdx1_Hoxc11:

Gene SymbolEntrez IDGene Name
Cdx1 ENSMUSG00000024619.8 Cdx1
Hoxc11 ENSMUSG00000001656.3 Hoxc11
Hoxd11 ENSMUSG00000042499.12 Hoxd11



Activity profile for motif Hoxd11_Cdx1_Hoxc11.

activity profile for motif Hoxd11_Cdx1_Hoxc11


Sorted Z-values histogram for motif Hoxd11_Cdx1_Hoxc11

Sorted Z-values for motif Hoxd11_Cdx1_Hoxc11



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_84064772 12.610 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr1_+_159737510 11.796 ENSMUST00000111669.3
 Tnr
tenascin R
chr4_+_144893127 9.751 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr17_-_91092715 9.327 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr15_+_81936911 8.927 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr5_-_62766153 8.413 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_+_3397189 8.398 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr15_+_81936753 8.339 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr4_+_144892813 6.476 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_105789869 5.879 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr4_-_64046925 5.098 ENSMUST00000107377.3
 Tnc
tenascin C
chr4_+_144893077 4.837 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_105790534 4.285 ENSMUST00000185012.1
 Gm12728
predicted gene 12728
chr8_+_57455898 4.238 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr18_+_69593361 4.217 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr3_+_62419668 4.209 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr13_-_101692624 4.082 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr5_-_62765618 3.561 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_-_42899470 3.315 ENSMUST00000120632.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr6_+_80018877 3.088 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 21.1 GO:0042572 retinol metabolic process(GO:0042572)
0.0 15.1 GO:0006397 mRNA processing(GO:0006397)
3.9 11.8 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
2.1 10.6 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 7.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.3 5.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.7 4.7 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.3 4.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 4.2 GO:0042118 endothelial cell activation(GO:0042118)
0.2 4.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.4 4.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 3.9 GO:0045814 negative regulation of gene expression, epigenetic(GO:0045814)
0.3 3.1 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.6 2.9 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 2.8 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.4 2.7 GO:0016584 nucleosome positioning(GO:0016584)
0.1 2.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.5 2.5 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 2.5 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.6 2.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 11.8 GO:0072534 perineuronal net(GO:0072534)
0.1 10.6 GO:0042734 presynaptic membrane(GO:0042734)
0.1 7.2 GO:0000786 nucleosome(GO:0000786)
0.1 5.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 5.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 5.1 GO:0005614 interstitial matrix(GO:0005614)
0.2 5.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 4.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.7 GO:0043204 perikaryon(GO:0043204)
0.6 2.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.4 GO:0030315 T-tubule(GO:0030315)
0.0 1.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.5 GO:0005795 Golgi stack(GO:0005795)
0.1 1.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.1 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 21.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 12.8 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 12.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.8 11.8 GO:0046625 sphingolipid binding(GO:0046625)
0.0 10.7 GO:0008134 transcription factor binding(GO:0008134)
0.9 10.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.8 5.1 GO:0045545 syndecan binding(GO:0045545)
0.3 4.7 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
1.1 4.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.0 4.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 3.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.6 2.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 2.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.6 2.5 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.6 2.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 2.2 GO:0016208 AMP binding(GO:0016208)
0.1 1.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 1.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.5 GO:0004407 histone deacetylase activity(GO:0004407)