Motif ID: Hoxd12

Z-value: 0.655


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710409 6.149 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 5.582 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_159737510 5.478 ENSMUST00000111669.3
Tnr
tenascin R
chr13_-_84064772 5.428 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr5_-_62766153 4.947 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_144893127 4.512 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 4.236 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr16_+_42907563 3.931 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr4_+_144893077 3.261 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr15_+_81936911 3.185 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr1_-_56969864 2.813 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr15_+_81936753 2.787 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr3_+_122419772 2.742 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr17_-_91092715 2.699 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr5_-_62765618 2.662 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_9403049 2.642 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
C030034L19Rik


RIKEN cDNA C030034L19 gene


chr1_-_56969827 2.539 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr13_-_101692624 2.495 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr18_-_35215008 2.263 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr2_+_73271925 2.150 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 12.0 GO:0042572 retinol metabolic process(GO:0042572)
2.9 11.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.8 5.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 5.5 GO:0006397 mRNA processing(GO:0006397)
0.3 5.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 4.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 3.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 3.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.5 2.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 2.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 2.5 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 2.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 2.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 2.1 GO:0046677 response to antibiotic(GO:0046677)
0.4 2.0 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.5 1.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 1.7 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.2 1.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.2 1.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.7 GO:0043205 fibril(GO:0043205)
0.1 6.2 GO:0000118 histone deacetylase complex(GO:0000118)
1.8 5.5 GO:0072534 perineuronal net(GO:0072534)
0.0 3.8 GO:0060076 excitatory synapse(GO:0060076)
0.0 2.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.7 GO:0016607 nuclear speck(GO:0016607)
0.1 2.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.6 GO:0031430 M band(GO:0031430)
0.1 1.1 GO:0005922 connexon complex(GO:0005922)
0.0 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.2 0.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.6 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.5 GO:0070820 tertiary granule(GO:0070820)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0033268 node of Ranvier(GO:0033268)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 12.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
2.3 11.7 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 7.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 5.5 GO:0046625 sphingolipid binding(GO:0046625)
0.0 4.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.2 3.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 2.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.6 2.5 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 2.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 2.2 GO:0038132 neuregulin binding(GO:0038132)
0.1 2.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.7 GO:0043422 protein kinase B binding(GO:0043422)
0.2 1.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.2 0.9 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.9 GO:0004407 histone deacetylase activity(GO:0004407)