Motif ID: Hoxd8

Z-value: 0.536


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_85127514 3.711 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr9_+_80165013 3.039 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6

myosin VI

chr3_+_76075583 2.529 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr1_+_9547948 2.272 ENSMUST00000144177.1
Adhfe1
alcohol dehydrogenase, iron containing, 1
chr2_+_83724397 2.051 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr9_+_80165079 1.945 ENSMUST00000184480.1
Myo6
myosin VI
chr3_+_127633134 1.904 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr3_+_94372794 1.847 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr10_+_97482350 1.535 ENSMUST00000163448.2
Dcn
decorin
chr5_-_62766153 1.471 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_178798438 1.445 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr12_-_84617326 1.315 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr1_-_127840290 1.181 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr17_-_48432723 1.168 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr9_+_54538984 1.167 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr3_-_116712644 1.017 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr19_+_23723279 0.926 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr12_-_87444017 0.907 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr6_+_71282280 0.873 ENSMUST00000080949.7
Krcc1
lysine-rich coiled-coil 1
chr15_-_35155750 0.820 ENSMUST00000067033.7
ENSMUST00000018476.7
Stk3

serine/threonine kinase 3

chr17_+_74489492 0.805 ENSMUST00000024873.6
Yipf4
Yip1 domain family, member 4
chrX_+_56786527 0.768 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr8_-_84662841 0.751 ENSMUST00000060427.4
Ier2
immediate early response 2
chr1_-_138848576 0.739 ENSMUST00000112030.2
Lhx9
LIM homeobox protein 9
chr7_+_110772604 0.733 ENSMUST00000005829.6
Ampd3
adenosine monophosphate deaminase 3
chr18_+_11633276 0.726 ENSMUST00000115861.2
Rbbp8
retinoblastoma binding protein 8
chr3_-_96197580 0.722 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chr14_+_58893465 0.694 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr8_+_40354303 0.638 ENSMUST00000136835.1
Micu3
mitochondrial calcium uptake family, member 3
chr1_-_126830632 0.633 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr1_-_172027269 0.601 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr1_-_158814469 0.593 ENSMUST00000161589.2
Pappa2
pappalysin 2
chr3_+_88716838 0.565 ENSMUST00000029692.8
ENSMUST00000171645.1
Rit1

Ras-like without CAAX 1

chr8_-_106573461 0.560 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr11_+_109543694 0.550 ENSMUST00000106696.1
Arsg
arylsulfatase G
chr3_+_88716884 0.525 ENSMUST00000172252.1
Rit1
Ras-like without CAAX 1
chr10_+_58394361 0.513 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr6_+_34384218 0.501 ENSMUST00000038383.7
ENSMUST00000115051.1
Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr13_+_49608030 0.497 ENSMUST00000021822.5
Ogn
osteoglycin
chr9_-_55512156 0.469 ENSMUST00000034866.8
Etfa
electron transferring flavoprotein, alpha polypeptide
chr12_-_54695885 0.420 ENSMUST00000067272.8
Eapp
E2F-associated phosphoprotein
chr7_-_80405425 0.420 ENSMUST00000107362.3
ENSMUST00000135306.1
Furin

furin (paired basic amino acid cleaving enzyme)

chr5_-_38491948 0.401 ENSMUST00000129099.1
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr10_+_23797052 0.307 ENSMUST00000133289.1
Slc18b1
solute carrier family 18, subfamily B, member 1
chr17_-_32822200 0.288 ENSMUST00000179695.1
Zfp799
zinc finger protein 799
chr19_-_19001099 0.269 ENSMUST00000040153.8
ENSMUST00000112828.1
Rorb

RAR-related orphan receptor beta

chr11_+_16257706 0.267 ENSMUST00000109645.2
ENSMUST00000109647.2
Vstm2a

V-set and transmembrane domain containing 2A

chr6_-_60829826 0.232 ENSMUST00000163779.1
Snca
synuclein, alpha
chr9_-_57158288 0.232 ENSMUST00000065358.7
Commd4
COMM domain containing 4
chr3_+_10088173 0.222 ENSMUST00000061419.7
Gm9833
predicted gene 9833
chr11_+_117809653 0.208 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chrX_-_74393003 0.203 ENSMUST00000015427.6
Fam3a
family with sequence similarity 3, member A
chr11_+_117809687 0.201 ENSMUST00000120928.1
ENSMUST00000175737.1
Syngr2

synaptogyrin 2

chr1_-_126830786 0.188 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr7_+_39588931 0.188 ENSMUST00000178791.1
ENSMUST00000098511.3
Gm2058

predicted gene 2058

chr7_-_45062393 0.185 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr7_+_45062429 0.174 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
Nosip



nitric oxide synthase interacting protein



chr2_-_163472561 0.166 ENSMUST00000109418.1
Fitm2
fat storage-inducing transmembrane protein 2
chr5_-_111761697 0.161 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr5_-_73191848 0.140 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr13_-_58354862 0.136 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr12_-_90969768 0.112 ENSMUST00000181184.1
4930544I03Rik
RIKEN cDNA 4930544I03 gene
chr12_-_12940600 0.111 ENSMUST00000130990.1
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr5_+_107497718 0.109 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr4_+_118961578 0.106 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr14_+_55560010 0.100 ENSMUST00000147981.1
ENSMUST00000133256.1
Dcaf11

DDB1 and CUL4 associated factor 11

chrM_+_7759 0.097 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr8_-_21906412 0.095 ENSMUST00000051965.4
Defb11
defensin beta 11
chr3_-_95871367 0.094 ENSMUST00000142437.1
ENSMUST00000067298.4
Mrps21

mitochondrial ribosomal protein S21

chr8_+_33599608 0.090 ENSMUST00000009774.9
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr2_+_152669461 0.076 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
H13



histocompatibility 13



chr6_+_134640940 0.074 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr12_-_54695829 0.074 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
Eapp



E2F-associated phosphoprotein



chr14_+_55559993 0.069 ENSMUST00000117236.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr3_+_24333046 0.063 ENSMUST00000077389.6
Gm7536
predicted gene 7536
chr10_-_127030813 0.054 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr1_+_178405881 0.052 ENSMUST00000027775.7
Efcab2
EF-hand calcium binding domain 2
chr3_-_19264959 0.046 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr18_+_60774675 0.036 ENSMUST00000118551.1
Rps14
ribosomal protein S14
chr7_+_126976338 0.027 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr9_-_15301555 0.027 ENSMUST00000034414.8
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr10_-_25200110 0.026 ENSMUST00000100012.2
Akap7
A kinase (PRKA) anchor protein 7
chr18_+_55057557 0.020 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr15_+_99295087 0.004 ENSMUST00000128352.1
ENSMUST00000145482.1
Prpf40b

PRP40 pre-mRNA processing factor 40 homolog B (yeast)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.5 1.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.4 5.0 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.3 0.8 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 1.8 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.2 1.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 1.3 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 1.0 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 0.6 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 0.7 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 0.7 GO:0032264 IMP salvage(GO:0032264)
0.1 0.4 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 0.2 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
0.1 1.2 GO:0016556 mRNA modification(GO:0016556)
0.0 0.3 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.4 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.5 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 2.4 GO:0006818 hydrogen transport(GO:0006818)
0.0 0.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.5 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 1.9 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.1 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.2 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.1 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.2 5.0 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 0.6 GO:0060187 cell pole(GO:0060187)
0.1 0.5 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 1.5 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 0.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0008142 oxysterol binding(GO:0008142)
0.4 2.1 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.1 0.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.5 GO:0052650 retinal binding(GO:0016918) NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.6 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0 0.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 1.2 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 5.1 GO:0003774 motor activity(GO:0003774)
0.0 1.9 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.1 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 1.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.5 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.0 2.3 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.0 2.0 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)