Motif ID: Hoxd8

Z-value: 0.536


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Showing 1 to 20 of 84 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_85127514 3.711 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr9_+_80165013 3.039 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6

myosin VI

chr3_+_76075583 2.529 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr1_+_9547948 2.272 ENSMUST00000144177.1
Adhfe1
alcohol dehydrogenase, iron containing, 1
chr2_+_83724397 2.051 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr9_+_80165079 1.945 ENSMUST00000184480.1
Myo6
myosin VI
chr3_+_127633134 1.904 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr3_+_94372794 1.847 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr10_+_97482350 1.535 ENSMUST00000163448.2
Dcn
decorin
chr5_-_62766153 1.471 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_178798438 1.445 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr12_-_84617326 1.315 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr1_-_127840290 1.181 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr17_-_48432723 1.168 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr9_+_54538984 1.167 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr3_-_116712644 1.017 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr19_+_23723279 0.926 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr12_-_87444017 0.907 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr6_+_71282280 0.873 ENSMUST00000080949.7
Krcc1
lysine-rich coiled-coil 1
chr15_-_35155750 0.820 ENSMUST00000067033.7
ENSMUST00000018476.7
Stk3

serine/threonine kinase 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.0 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 2.4 GO:0006818 hydrogen transport(GO:0006818)
0.7 2.1 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.0 1.9 GO:0021954 central nervous system neuron development(GO:0021954)
0.3 1.8 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.2 1.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.5 1.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 1.3 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 1.2 GO:0016556 mRNA modification(GO:0016556)
0.2 1.0 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.3 0.8 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.2 0.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 0.7 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.7 GO:0032264 IMP salvage(GO:0032264)
0.2 0.6 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.5 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.5 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 0.4 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.7 2.1 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)
0.1 1.5 GO:0098644 complex of collagen trimers(GO:0098644)
0.2 0.6 GO:0060187 cell pole(GO:0060187)
0.1 0.5 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0003774 motor activity(GO:0003774)
0.0 2.3 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.4 2.1 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.0 2.0 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 1.9 GO:0070888 E-box binding(GO:0070888)
0.5 1.8 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.2 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 1.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 0.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.6 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 0.5 GO:0052650 retinal binding(GO:0016918) NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.5 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.1 0.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.2 GO:0050544 arachidonic acid binding(GO:0050544)