Motif ID: Hsf1
Z-value: 0.669
Transcription factors associated with Hsf1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hsf1 | ENSMUSG00000022556.9 | Hsf1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hsf1 | mm10_v2_chr15_+_76477404_76477461 | 0.14 | 3.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 10.4 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 1.8 | 7.2 | GO:0045343 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) |
| 1.6 | 4.7 | GO:1903054 | lysosomal membrane organization(GO:0097212) negative regulation of extracellular matrix organization(GO:1903054) positive regulation of protein folding(GO:1903334) |
| 1.4 | 8.1 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 1.1 | 3.4 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 1.0 | 5.1 | GO:0060838 | lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 1.0 | 10.7 | GO:1990173 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
| 0.8 | 2.5 | GO:0002842 | T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842) |
| 0.7 | 3.0 | GO:0030576 | Cajal body organization(GO:0030576) |
| 0.6 | 3.7 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
| 0.6 | 1.7 | GO:0097278 | complement-dependent cytotoxicity(GO:0097278) |
| 0.5 | 1.4 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.4 | 1.7 | GO:0060032 | notochord regression(GO:0060032) |
| 0.4 | 1.3 | GO:0002295 | T-helper cell lineage commitment(GO:0002295) interleukin-4-mediated signaling pathway(GO:0035771) |
| 0.4 | 2.1 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.3 | 1.2 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.3 | 0.8 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
| 0.2 | 2.0 | GO:0061084 | regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084) |
| 0.2 | 2.0 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.2 | 1.9 | GO:0031053 | primary miRNA processing(GO:0031053) |
| 0.2 | 1.2 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 0.2 | 4.7 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.2 | 0.7 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.2 | 1.0 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
| 0.2 | 1.0 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.2 | 0.5 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.2 | 2.0 | GO:0090037 | positive regulation of protein kinase C signaling(GO:0090037) |
| 0.2 | 1.4 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.2 | 0.8 | GO:2000298 | regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 0.2 | 0.5 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
| 0.1 | 1.6 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.1 | 2.5 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.1 | 0.8 | GO:0042535 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
| 0.1 | 1.6 | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051) |
| 0.1 | 1.1 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.1 | 1.6 | GO:0030238 | male sex determination(GO:0030238) |
| 0.1 | 1.3 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.5 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.1 | 1.0 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
| 0.1 | 1.9 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 1.0 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.1 | 0.7 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.1 | 0.3 | GO:0034729 | histone H3-K79 methylation(GO:0034729) |
| 0.1 | 1.5 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.1 | 0.6 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.1 | 1.5 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.1 | 0.6 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.1 | 0.8 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.1 | 1.2 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.1 | 0.3 | GO:0015692 | vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) |
| 0.0 | 0.5 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.0 | 0.2 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.0 | 0.2 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.0 | 0.4 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.0 | 1.1 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 1.1 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.1 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 0.0 | 0.2 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.0 | 0.1 | GO:0009838 | abscission(GO:0009838) |
| 0.0 | 0.8 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 1.3 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
| 0.0 | 0.1 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 8.1 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 1.2 | 4.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 1.0 | 10.7 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.6 | 1.7 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.5 | 1.4 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.4 | 2.5 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.3 | 1.0 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
| 0.2 | 0.7 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.2 | 1.9 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.1 | 1.7 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 4.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 1.1 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 3.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 0.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 3.8 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 2.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 0.7 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.1 | 0.3 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 1.1 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 7.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 3.4 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 4.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 1.9 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 0.3 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 2.1 | GO:0044452 | nucleolar part(GO:0044452) |
| 0.0 | 0.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.8 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.1 | GO:0097422 | tubular endosome(GO:0097422) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 9.9 | GO:0002135 | CTP binding(GO:0002135) |
| 1.6 | 4.7 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
| 1.3 | 3.9 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 1.0 | 3.0 | GO:0070140 | isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140) |
| 0.9 | 4.7 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.7 | 2.0 | GO:0032564 | dATP binding(GO:0032564) |
| 0.6 | 5.1 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.5 | 1.9 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.4 | 3.4 | GO:0031432 | titin binding(GO:0031432) |
| 0.4 | 2.1 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.4 | 1.6 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.4 | 1.2 | GO:0004307 | ethanolaminephosphotransferase activity(GO:0004307) |
| 0.4 | 1.9 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.3 | 2.5 | GO:0043559 | insulin binding(GO:0043559) |
| 0.3 | 1.2 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.3 | 2.0 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.3 | 2.0 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.2 | 7.2 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.2 | 1.6 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.2 | 3.8 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.2 | 1.0 | GO:0070883 | importin-alpha family protein binding(GO:0061676) pre-miRNA binding(GO:0070883) |
| 0.2 | 1.4 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 0.7 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 0.1 | 0.5 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 1.0 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 1.3 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 2.3 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.1 | 3.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 3.3 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.1 | 1.1 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 0.6 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 2.5 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.1 | 0.5 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.1 | 0.3 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.0 | 0.2 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.0 | 12.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.8 | GO:0030291 | protein serine/threonine kinase inhibitor activity(GO:0030291) |
| 0.0 | 0.8 | GO:0035380 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677) |
| 0.0 | 1.1 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 1.3 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 1.1 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.8 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 1.9 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.2 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.0 | 1.4 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.0 | 1.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
