Motif ID: Hsf2

Z-value: 2.296


Transcription factors associated with Hsf2:

Gene SymbolEntrez IDGene Name
Hsf2 ENSMUSG00000019878.7 Hsf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf2mm10_v2_chr10_+_57486354_57486414-0.273.8e-02Click!


Activity profile for motif Hsf2.

activity profile for motif Hsf2


Sorted Z-values histogram for motif Hsf2

Sorted Z-values for motif Hsf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48667508 22.652 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr17_-_70851189 20.610 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr17_-_25797032 18.994 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr17_-_70849644 17.115 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr10_-_92164666 16.852 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr2_+_120463566 14.983 ENSMUST00000028749.7
ENSMUST00000110721.1
 Capn3

calpain 3

chr12_-_56536895 14.321 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr14_+_19751257 14.258 ENSMUST00000022340.3
 Nid2
nidogen 2
chr7_-_4752972 13.330 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr11_+_120949053 12.951 ENSMUST00000154187.1
ENSMUST00000100130.3
ENSMUST00000129473.1
ENSMUST00000168579.1
 Slc16a3



solute carrier family 16 (monocarboxylic acid transporters), member 3



chr9_+_65141154 12.399 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr1_-_72874877 12.158 ENSMUST00000027377.8
 Igfbp5
insulin-like growth factor binding protein 5
chr17_-_58991343 11.881 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr10_+_84838143 11.793 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr5_+_92603039 11.567 ENSMUST00000050952.3
 Stbd1
starch binding domain 1
chr11_-_11970540 11.490 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr12_-_10900296 11.414 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr5_-_5514730 10.985 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr6_-_72235559 10.851 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr6_-_119467210 10.777 ENSMUST00000118120.1
 Wnt5b
wingless-related MMTV integration site 5B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 280 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 46.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.9 24.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
1.2 23.3 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.4 23.0 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
5.7 22.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
4.0 20.1 GO:2000981 negative regulation of mechanoreceptor differentiation(GO:0045632) negative regulation of inner ear receptor cell differentiation(GO:2000981)
1.3 18.3 GO:0030238 male sex determination(GO:0030238)
0.2 16.7 GO:0050772 positive regulation of axonogenesis(GO:0050772)
1.0 15.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.8 15.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
5.0 15.0 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.3 14.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
4.8 14.3 GO:0021759 globus pallidus development(GO:0021759)
0.7 13.6 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.6 13.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
2.1 12.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.7 12.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
2.4 11.8 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
2.0 11.8 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.1 11.8 GO:0007517 muscle organ development(GO:0007517)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 51.1 GO:0005634 nucleus(GO:0005634)
0.0 36.9 GO:0005739 mitochondrion(GO:0005739)
0.5 24.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 21.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 18.2 GO:0009986 cell surface(GO:0009986)
0.2 18.1 GO:0005604 basement membrane(GO:0005604)
0.3 16.4 GO:0016459 myosin complex(GO:0016459)
0.1 14.9 GO:0005802 trans-Golgi network(GO:0005802)
1.0 13.3 GO:0030061 mitochondrial crista(GO:0030061)
1.6 13.1 GO:0005818 aster(GO:0005818)
0.1 12.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
3.0 12.2 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0 12.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 12.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
2.4 11.8 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.2 11.8 GO:0031985 Golgi cisterna(GO:0031985)
1.9 11.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 11.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.7 10.7 GO:0045180 basal cortex(GO:0045180)
0.1 10.5 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 222 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 46.3 GO:0070410 co-SMAD binding(GO:0070410)
0.2 40.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 24.7 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.6 17.4 GO:0071837 HMG box domain binding(GO:0071837)
0.7 17.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.7 15.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.0 15.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
1.9 15.0 GO:0031432 titin binding(GO:0031432)
0.1 14.7 GO:0051015 actin filament binding(GO:0051015)
2.4 14.4 GO:0002135 CTP binding(GO:0002135)
1.2 14.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 14.2 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
4.6 13.9 GO:0005118 sevenless binding(GO:0005118)
0.1 13.5 GO:0003735 structural constituent of ribosome(GO:0003735)
2.6 13.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.8 13.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 13.0 GO:0008237 metallopeptidase activity(GO:0008237)
0.3 12.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 12.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.8 12.5 GO:0051018 protein kinase A binding(GO:0051018)