Motif ID: Hsf4

Z-value: 0.768


Transcription factors associated with Hsf4:

Gene SymbolEntrez IDGene Name
Hsf4 ENSMUSG00000033249.4 Hsf4



Activity profile for motif Hsf4.

activity profile for motif Hsf4


Sorted Z-values histogram for motif Hsf4

Sorted Z-values for motif Hsf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_194938821 4.512 ENSMUST00000016638.2
ENSMUST00000110815.2
 Cd34

CD34 antigen

chr12_+_75308308 4.085 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr16_+_91225550 2.395 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr1_-_79858627 2.297 ENSMUST00000027467.4
 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr7_-_19310035 2.234 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr12_-_110696332 2.231 ENSMUST00000094361.4
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chrX_+_71663665 2.187 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50
chr19_-_5802640 1.962 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr2_-_172370506 1.956 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr1_-_189688074 1.926 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr12_-_110696289 1.804 ENSMUST00000021698.6
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr18_+_50051702 1.794 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr15_+_75704280 1.752 ENSMUST00000121137.1
ENSMUST00000023244.5
 Rhpn1

rhophilin, Rho GTPase binding protein 1

chr12_-_110696248 1.707 ENSMUST00000124156.1
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr11_-_90002881 1.695 ENSMUST00000020864.8
 Pctp
phosphatidylcholine transfer protein
chr2_+_121456963 1.653 ENSMUST00000126764.1
 Hypk
huntingtin interacting protein K
chr17_+_47593444 1.651 ENSMUST00000182209.1
 Ccnd3
cyclin D3
chr19_-_50030735 1.622 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr18_-_10706688 1.621 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
 Abhd3


abhydrolase domain containing 3


chr12_-_110695860 1.590 ENSMUST00000149189.1
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.3 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.2 6.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
1.5 4.5 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.3 4.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.2 3.9 GO:0070986 left/right axis specification(GO:0070986)
0.3 2.7 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.5 2.6 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.8 2.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.8 2.3 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 2.3 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 2.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.4 2.1 GO:1905049 negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.1 2.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.5 2.0 GO:0035063 nuclear speck organization(GO:0035063)
0.5 2.0 GO:0007056 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.1 1.9 GO:0021591 ventricular system development(GO:0021591)
0.1 1.8 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.4 1.7 GO:0030576 Cajal body organization(GO:0030576)
0.2 1.7 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 1.7 GO:0015914 phospholipid transport(GO:0015914)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.3 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.5 6.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.4 5.7 GO:0046930 pore complex(GO:0046930)
0.1 4.1 GO:0005882 intermediate filament(GO:0005882)
0.0 4.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.7 GO:0043235 receptor complex(GO:0043235)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.9 GO:0005604 basement membrane(GO:0005604)
0.1 2.5 GO:0015030 Cajal body(GO:0015030)
0.2 2.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 2.4 GO:0000793 condensed chromosome(GO:0000793)
0.0 2.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 2.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.1 GO:0005681 spliceosomal complex(GO:0005681)
0.7 2.0 GO:0042585 germinal vesicle(GO:0042585)
0.0 2.0 GO:0016607 nuclear speck(GO:0016607)
0.1 1.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 1.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 1.7 GO:0045111 intermediate filament cytoskeleton(GO:0045111)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 7.3 GO:0030911 TPR domain binding(GO:0030911)
0.0 7.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4 6.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 4.1 GO:0003924 GTPase activity(GO:0003924)
0.1 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.2 GO:0030246 carbohydrate binding(GO:0030246)
0.2 3.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.9 2.8 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.4 2.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 2.4 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 2.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.7 2.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.7 2.2 GO:0005118 sevenless binding(GO:0005118)
0.3 2.0 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 1.9 GO:0045502 dynein binding(GO:0045502)
0.1 1.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.6 1.7 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.6 1.7 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)