Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 3.559

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:

Gene SymbolEntrez IDGene Name
Irf1 ENSMUSG00000018899.10 Irf1
Irf2 ENSMUSG00000031627.7 Irf2
Irf7 ENSMUSG00000025498.8 Irf7
Irf8 ENSMUSG00000041515.3 Irf8
Irf9 ENSMUSG00000002325.8 Irf9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770014_537700570.321.3e-02Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.229.9e-02Click!
Irf7mm10_v2_chr7_-_141266415_1412664810.123.5e-01Click!
Irf2mm10_v2_chr8_+_46739745_46739791-0.114.1e-01Click!
Irf9mm10_v2_chr14_+_55604550_556045790.028.7e-01Click!


Activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7.

activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7


Sorted Z-values histogram for motif Irf2_Irf1_Irf8_Irf9_Irf7

Sorted Z-values for motif Irf2_Irf1_Irf8_Irf9_Irf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 65.351 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3034599 64.301 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3015654 60.622 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3023547 60.488 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3004457 58.127 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3027439 57.382 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3017408 56.732 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3000922 54.615 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr2_-_98667264 54.587 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr14_-_19418930 54.566 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3037111 52.128 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3005125 51.749 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3036877 49.203 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3018753 48.607 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3025417 47.244 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_+_98662227 24.750 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chrX_-_134161928 22.758 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr2_+_122147680 16.550 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr7_-_102565425 14.872 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chr2_-_105399286 14.452 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 329 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 28.0 GO:0071346 cellular response to interferon-gamma(GO:0071346)
4.3 21.3 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.4 16.6 GO:0010390 histone monoubiquitination(GO:0010390)
2.0 16.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
3.0 14.9 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
1.8 14.6 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
1.1 13.1 GO:0044458 motile cilium assembly(GO:0044458)
1.3 10.7 GO:0048625 myoblast fate commitment(GO:0048625)
1.5 10.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
1.5 10.5 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
1.1 10.1 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.7 9.3 GO:0097066 response to thyroid hormone(GO:0097066)
0.9 8.1 GO:0085020 protein K6-linked ubiquitination(GO:0085020)
2.0 7.9 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
2.0 7.8 GO:1900426 positive regulation of defense response to bacterium(GO:1900426)
0.1 7.7 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.2 7.6 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.5 7.4 GO:0034501 protein localization to kinetochore(GO:0034501)
2.4 7.3 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.4 7.1 GO:0038092 nodal signaling pathway(GO:0038092)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 385.7 GO:0005575 cellular_component(GO:0005575)
2.8 36.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 21.6 GO:0016605 PML body(GO:0016605)
0.0 16.0 GO:0005667 transcription factor complex(GO:0005667)
1.5 13.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 12.9 GO:0036126 sperm flagellum(GO:0036126)
0.1 12.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 10.8 GO:0030914 STAGA complex(GO:0030914)
1.2 10.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 8.3 GO:0005604 basement membrane(GO:0005604)
2.6 7.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.8 7.6 GO:0030478 actin cap(GO:0030478)
0.1 7.0 GO:0031519 PcG protein complex(GO:0031519)
1.7 6.8 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 6.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
1.7 6.7 GO:0043020 NADPH oxidase complex(GO:0043020)
1.1 6.7 GO:0005663 DNA replication factor C complex(GO:0005663)
0.6 6.7 GO:0020003 symbiont-containing vacuole(GO:0020003)
1.3 6.5 GO:1990462 omegasome(GO:1990462)
0.1 6.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 188.3 GO:0003674 molecular_function(GO:0003674)
0.1 40.7 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
1.0 23.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
1.3 18.6 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 17.8 GO:0004386 helicase activity(GO:0004386)
0.1 13.8 GO:0001948 glycoprotein binding(GO:0001948)
2.5 12.4 GO:0032027 myosin light chain binding(GO:0032027)
0.6 10.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.5 10.7 GO:0045295 gamma-catenin binding(GO:0045295)
0.8 10.2 GO:0031386 protein tag(GO:0031386)
0.0 9.8 GO:0003924 GTPase activity(GO:0003924)
0.2 9.7 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)
0.7 9.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 9.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.9 8.6 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.3 8.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.9 8.3 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.5 8.2 GO:0017166 vinculin binding(GO:0017166)
0.5 8.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4 7.6 GO:0001848 complement binding(GO:0001848)