Motif ID: Irf3

Z-value: 0.789


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.429.4e-04Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_36409719 4.211 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr3_+_81932601 4.029 ENSMUST00000029649.2
 Ctso
cathepsin O
chr2_-_105399286 3.766 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr3_+_142560108 3.287 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr16_+_35938470 3.139 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr7_-_104315455 3.106 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr3_+_142560052 3.072 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr6_-_39118211 3.056 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr13_+_74639866 2.888 ENSMUST00000169114.1
 Erap1
endoplasmic reticulum aminopeptidase 1
chr3_+_142560351 2.883 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr16_+_35938972 2.757 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr14_-_65833963 2.756 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr3_+_142530329 2.719 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr2_-_51934644 2.705 ENSMUST00000165313.1
 Rbm43
RNA binding motif protein 43
chr1_+_61638819 2.327 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr18_-_32559914 2.158 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr15_+_32920723 2.104 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr7_-_100514800 2.037 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr14_+_14012491 2.031 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr11_+_72301613 1.913 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr11_-_48871408 1.890 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chrX_+_68678712 1.815 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
 Fmr1



fragile X mental retardation syndrome 1



chr2_+_122147680 1.801 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr7_-_102565425 1.763 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chr16_-_19706365 1.729 ENSMUST00000081880.5
 Lamp3
lysosomal-associated membrane protein 3
chrX_+_68678541 1.712 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr19_+_43752996 1.579 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chr4_-_40239700 1.566 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_109362771 1.557 ENSMUST00000020930.7
ENSMUST00000106702.3
 Gna13

guanine nucleotide binding protein, alpha 13

chr10_-_87493651 1.462 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr17_+_75178797 1.460 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr2_-_173276144 1.442 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr17_+_75178911 1.426 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr13_-_23710714 1.396 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr2_-_51934943 1.387 ENSMUST00000102767.1
ENSMUST00000102768.1
 Rbm43

RNA binding motif protein 43

chrX_+_68678624 1.291 ENSMUST00000114656.1
 Fmr1
fragile X mental retardation syndrome 1
chr5_-_137116177 1.291 ENSMUST00000054384.5
ENSMUST00000152207.1
 Trim56

tripartite motif-containing 56

chr8_-_80739497 1.203 ENSMUST00000043359.8
 Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr4_-_40239779 1.175 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr3_-_50443603 1.166 ENSMUST00000029297.4
 Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr11_+_119393060 1.161 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr11_-_48871344 1.120 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr15_+_79892397 1.056 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr6_-_125231772 1.029 ENSMUST00000043422.7
 Tapbpl
TAP binding protein-like
chr2_-_62646146 1.017 ENSMUST00000112459.3
ENSMUST00000028259.5
 Ifih1

interferon induced with helicase C domain 1

chr6_-_23839137 0.983 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
 Cadps2







Ca2+-dependent activator protein for secretion 2







chr7_-_116198487 0.978 ENSMUST00000181981.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr2_+_152962485 0.972 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr15_+_79892436 0.847 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr6_-_34317442 0.799 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr7_-_45136231 0.793 ENSMUST00000124300.1
ENSMUST00000085377.5
 Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chr11_+_58199556 0.788 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr10_+_83543941 0.763 ENSMUST00000038388.5
 A230046K03Rik
RIKEN cDNA A230046K03 gene
chr16_+_23609895 0.739 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr16_-_35939082 0.731 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)

chr2_-_126933229 0.710 ENSMUST00000028844.4
 Sppl2a
signal peptide peptidase like 2A
chr16_-_10785525 0.609 ENSMUST00000038099.4
 Socs1
suppressor of cytokine signaling 1
chr6_-_54972603 0.584 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr9_-_35176039 0.544 ENSMUST00000119847.1
ENSMUST00000034539.5
 Dcps

decapping enzyme, scavenger

chr2_-_145935014 0.536 ENSMUST00000001818.4
 Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr6_-_56797761 0.432 ENSMUST00000114321.1
 Kbtbd2
kelch repeat and BTB (POZ) domain containing 2
chr1_+_85600672 0.426 ENSMUST00000080204.4
 Sp140
Sp140 nuclear body protein
chr8_-_71537402 0.419 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr15_-_39112642 0.302 ENSMUST00000022908.8
 Slc25a32
solute carrier family 25, member 32
chrX_+_101429555 0.295 ENSMUST00000033673.6
 Nono
non-POU-domain-containing, octamer binding protein
chr1_-_85109449 0.268 ENSMUST00000161724.1
 A530032D15Rik
RIKEN cDNA A530032D15Rik gene
chr6_-_56797637 0.259 ENSMUST00000114323.1
 Kbtbd2
kelch repeat and BTB (POZ) domain containing 2
chr17_+_21008921 0.237 ENSMUST00000088811.5
 Zfp160
zinc finger protein 160
chr1_-_37890333 0.220 ENSMUST00000139725.1
ENSMUST00000027257.8
 Mitd1

MIT, microtubule interacting and transport, domain containing 1

chr17_+_34187789 0.189 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chrX_-_38576166 0.185 ENSMUST00000050083.5
 Cul4b
cullin 4B
chr10_-_81496313 0.183 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr17_+_34187545 0.177 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chrX_-_38576189 0.170 ENSMUST00000115118.1
 Cul4b
cullin 4B
chr10_-_81496329 0.159 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr11_-_49064202 0.142 ENSMUST00000046745.6
 Tgtp2
T cell specific GTPase 2
chr2_+_180589245 0.142 ENSMUST00000029087.3
 Ogfr
opioid growth factor receptor
chr5_+_123252087 0.077 ENSMUST00000121964.1
 Wdr66
WD repeat domain 66
chr9_+_108508005 0.073 ENSMUST00000006838.8
ENSMUST00000134939.1
 Qars

glutaminyl-tRNA synthetase

chr19_-_43752924 0.060 ENSMUST00000045562.5
 Cox15
cytochrome c oxidase assembly protein 15
chr18_+_23989632 0.038 ENSMUST00000074941.7
 Zfp35
zinc finger protein 35

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:1901254 positive regulation of intracellular transport of viral material(GO:1901254)
0.9 6.5 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.8 2.4 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
0.8 12.0 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.7 2.7 GO:0009597 detection of virus(GO:0009597)
0.6 2.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.5 1.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.5 1.8 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.4 0.4 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.4 1.8 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.3 1.0 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.3 1.9 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.3 2.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 1.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 3.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3 0.8 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.3 0.8 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.2 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 1.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.2 1.6 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 1.2 GO:0016584 nucleosome positioning(GO:0016584)
0.2 1.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.6 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.1 1.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 2.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.7 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 1.7 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 1.6 GO:0055070 copper ion homeostasis(GO:0055070)
0.1 2.1 GO:0035456 response to interferon-beta(GO:0035456)
0.1 1.0 GO:0046597 negative regulation of viral entry into host cell(GO:0046597) negative regulation of viral release from host cell(GO:1902187)
0.1 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 1.0 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.3 GO:0006544 glycine metabolic process(GO:0006544)
0.0 0.4 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.7 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.8 GO:0007032 endosome organization(GO:0007032)
0.0 2.1 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 2.0 GO:0006457 protein folding(GO:0006457)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
1.1 12.0 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
1.0 2.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.8 0.8 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.6 1.7 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.5 2.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 3.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 0.8 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.7 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.8 GO:0097452 GAIT complex(GO:0097452)
0.1 1.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.1 2.0 GO:0030914 STAGA complex(GO:0030914)
0.1 0.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 4.2 GO:0031519 PcG protein complex(GO:0031519)
0.1 2.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.8 GO:0071203 WASH complex(GO:0071203)
0.1 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825)
0.1 0.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 1.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.0 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.0 GO:0005770 late endosome(GO:0005770)
0.0 2.2 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.7 2.9 GO:0050436 microfibril binding(GO:0050436)
0.7 2.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.5 1.6 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.5 1.9 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.4 8.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 2.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 1.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 1.4 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.4 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 4.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 9.4 GO:0003924 GTPase activity(GO:0003924)
0.0 1.4 GO:0050699 WW domain binding(GO:0050699)
0.0 1.5 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 3.0 GO:0005525 GTP binding(GO:0005525)
0.0 2.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.8 GO:0001948 glycoprotein binding(GO:0001948)
0.0 0.7 GO:0031491 nucleosome binding(GO:0031491)