Motif ID: Irf3

Z-value: 0.789


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.429.4e-04Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_36409719 4.211 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr3_+_81932601 4.029 ENSMUST00000029649.2
 Ctso
cathepsin O
chr2_-_105399286 3.766 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr3_+_142560108 3.287 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr16_+_35938470 3.139 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr7_-_104315455 3.106 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr3_+_142560052 3.072 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr6_-_39118211 3.056 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr13_+_74639866 2.888 ENSMUST00000169114.1
 Erap1
endoplasmic reticulum aminopeptidase 1
chr3_+_142560351 2.883 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr16_+_35938972 2.757 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr14_-_65833963 2.756 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr3_+_142530329 2.719 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr2_-_51934644 2.705 ENSMUST00000165313.1
 Rbm43
RNA binding motif protein 43
chr1_+_61638819 2.327 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr18_-_32559914 2.158 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr15_+_32920723 2.104 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr7_-_100514800 2.037 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr14_+_14012491 2.031 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr11_+_72301613 1.913 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 12.0 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.9 6.5 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
1.6 4.8 GO:1901254 positive regulation of intracellular transport of viral material(GO:1901254)
0.3 3.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 2.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.6 2.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.7 2.7 GO:0009597 detection of virus(GO:0009597)
0.8 2.4 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
0.1 2.1 GO:0035456 response to interferon-beta(GO:0035456)
0.0 2.1 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.3 2.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 2.0 GO:0006457 protein folding(GO:0006457)
0.3 1.9 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.5 1.8 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.4 1.8 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 1.7 GO:0035455 response to interferon-alpha(GO:0035455)
0.2 1.6 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 1.6 GO:0055070 copper ion homeostasis(GO:0055070)
0.5 1.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.3 1.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 12.0 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 5.1 GO:0005923 bicellular tight junction(GO:0005923)
1.6 4.8 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.1 4.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 3.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.3 3.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 3.0 GO:0005770 late endosome(GO:0005770)
1.0 2.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 2.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 2.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 2.2 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 2.0 GO:0030914 STAGA complex(GO:0030914)
0.0 2.0 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.6 1.7 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 1.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0003924 GTPase activity(GO:0003924)
0.4 8.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
1.0 4.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 4.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 3.0 GO:0005525 GTP binding(GO:0005525)
0.7 2.9 GO:0050436 microfibril binding(GO:0050436)
0.4 2.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.7 2.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 2.1 GO:0030165 PDZ domain binding(GO:0030165)
0.5 1.9 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 1.8 GO:0001948 glycoprotein binding(GO:0001948)
0.5 1.6 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 1.5 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.2 1.4 GO:0039706 co-receptor binding(GO:0039706)
0.0 1.4 GO:0050699 WW domain binding(GO:0050699)
0.0 1.3 GO:0051082 unfolded protein binding(GO:0051082)
0.3 1.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)