Motif ID: Irf5_Irf6

Z-value: 0.714

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6






Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_142395661 9.331 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
Pdlim5



PDZ and LIM domain 5



chr7_-_141010759 7.853 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr2_-_69586021 7.074 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
Lrp2


low density lipoprotein receptor-related protein 2


chr11_+_88999376 5.718 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25


tripartite motif-containing 25


chr17_+_23679363 5.400 ENSMUST00000024699.2
Cldn6
claudin 6
chr1_-_163313661 5.365 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr7_+_128523576 4.399 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr19_+_55741810 4.069 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr9_+_45042425 4.017 ENSMUST00000034600.4
Mpzl2
myelin protein zero-like 2
chr9_-_14381242 2.554 ENSMUST00000167549.1
Endod1
endonuclease domain containing 1
chr16_+_35938972 2.388 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr11_-_86201144 2.208 ENSMUST00000044423.3
Brip1
BRCA1 interacting protein C-terminal helicase 1
chr6_-_39118211 2.183 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr4_-_40239779 2.125 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr5_+_92809372 2.121 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr6_+_57580992 2.043 ENSMUST00000031817.8
Herc6
hect domain and RLD 6
chr11_+_69966896 1.833 ENSMUST00000151515.1
Cldn7
claudin 7
chr15_+_9436028 1.829 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr4_-_40239700 1.671 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_-_73113407 1.622 ENSMUST00000175693.1
Six4
sine oculis-related homeobox 4
chrX_+_77511002 1.604 ENSMUST00000088217.5
Tbl1x
transducin (beta)-like 1 X-linked
chr16_-_5255923 1.600 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86

family with sequence similarity 86

chr2_-_51934644 1.490 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr7_-_65370908 1.488 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr16_+_35938470 1.473 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr2_-_77170592 1.227 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr9_-_123851855 1.177 ENSMUST00000184082.1
ENSMUST00000167595.2
Fyco1

FYVE and coiled-coil domain containing 1

chr6_-_13608011 1.104 ENSMUST00000031554.2
Tmem168
transmembrane protein 168
chr9_+_57072024 1.086 ENSMUST00000169879.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr11_+_60699758 1.083 ENSMUST00000108719.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr16_-_91646906 1.060 ENSMUST00000120450.1
ENSMUST00000023684.7
Gart

phosphoribosylglycinamide formyltransferase

chr5_-_99978914 1.055 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
Hnrnpd




heterogeneous nuclear ribonucleoprotein D




chr17_+_34203527 0.896 ENSMUST00000025197.5
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_+_83755904 0.836 ENSMUST00000051522.8
ENSMUST00000042280.7
Gm7964

predicted gene 7964

chr15_+_96287518 0.810 ENSMUST00000134985.2
ENSMUST00000096250.4
Arid2

AT rich interactive domain 2 (ARID, RFX-like)

chr11_+_60699718 0.770 ENSMUST00000052346.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr17_-_78882508 0.739 ENSMUST00000024884.4
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chrM_+_8600 0.720 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chrM_+_9452 0.620 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr3_+_135438722 0.615 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr12_+_26469204 0.610 ENSMUST00000020969.3
Cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chrX_-_95444789 0.601 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr16_-_35939082 0.597 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr11_+_72301613 0.570 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
Xaf1


XIAP associated factor 1


chr1_+_52119438 0.550 ENSMUST00000070968.7
Stat1
signal transducer and activator of transcription 1
chr15_+_99126513 0.539 ENSMUST00000063517.4
Spats2
spermatogenesis associated, serine-rich 2
chr6_-_87838671 0.527 ENSMUST00000089497.4
Isy1
ISY1 splicing factor homolog (S. cerevisiae)
chr11_+_101582236 0.514 ENSMUST00000039581.7
ENSMUST00000100403.2
ENSMUST00000107194.1
ENSMUST00000128614.1
Tmem106a



transmembrane protein 106A



chr4_-_58911902 0.486 ENSMUST00000134848.1
ENSMUST00000107557.2
ENSMUST00000149301.1
AI314180


expressed sequence AI314180


chr5_+_99979061 0.483 ENSMUST00000046721.1
4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr1_-_184732616 0.473 ENSMUST00000048572.6
Hlx
H2.0-like homeobox
chr12_-_31950170 0.429 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr8_-_105568298 0.393 ENSMUST00000005849.5
Agrp
agouti related protein
chr4_-_136886187 0.309 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chr17_-_6782775 0.230 ENSMUST00000064234.6
Ezr
ezrin
chr9_+_55326913 0.186 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr3_-_32616479 0.157 ENSMUST00000108234.1
ENSMUST00000155737.1
Gnb4

guanine nucleotide binding protein (G protein), beta 4

chr11_-_78984831 0.147 ENSMUST00000073001.4
ENSMUST00000108269.3
Lgals9

lectin, galactose binding, soluble 9

chr12_-_31950210 0.139 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr7_-_126396715 0.127 ENSMUST00000075671.4
Nfatc2ip
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chrX_-_101222426 0.126 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr4_+_108460000 0.110 ENSMUST00000097925.2
Zcchc11
zinc finger, CCHC domain containing 11
chr11_-_78984946 0.078 ENSMUST00000108268.3
Lgals9
lectin, galactose binding, soluble 9
chr11_+_29130733 0.056 ENSMUST00000020756.8
Pnpt1
polyribonucleotide nucleotidyltransferase 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0009597 detection of virus(GO:0009597)
0.7 13.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.7 7.1 GO:0045056 transcytosis(GO:0045056)
0.6 3.9 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.5 1.6 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) skeletal muscle fiber differentiation(GO:0098528)
0.5 4.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.4 5.4 GO:0048664 neuron fate determination(GO:0048664)
0.4 1.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.4 1.1 GO:0045472 response to ether(GO:0045472)
0.3 9.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 1.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 0.9 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.2 1.1 GO:0046654 'de novo' IMP biosynthetic process(GO:0006189) tetrahydrofolate biosynthetic process(GO:0046654)
0.2 0.6 GO:0046077 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.2 1.9 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.2 0.5 GO:0000389 generation of catalytic spliceosome for second transesterification step(GO:0000350) mRNA 3'-splice site recognition(GO:0000389)
0.2 4.4 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.2 1.8 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 0.6 GO:0060333 regulation of macrophage fusion(GO:0034239) interferon-gamma-mediated signaling pathway(GO:0060333)
0.1 1.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.1 GO:2000642 negative regulation of vacuolar transport(GO:1903336) negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.7 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 0.5 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 0.2 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.1 0.6 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.2 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.1 0.8 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.0 3.6 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 1.2 GO:0051642 centrosome localization(GO:0051642)
0.0 2.1 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 5.4 GO:0045216 cell-cell junction organization(GO:0045216)
0.0 0.6 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 1.6 GO:0043627 response to estrogen(GO:0043627)
0.0 0.6 GO:0035456 response to interferon-beta(GO:0035456)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 2.0 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.7 GO:0022904 respiratory electron transport chain(GO:0022904)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.4 8.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.9 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.9 GO:0042825 TAP complex(GO:0042825)
0.1 13.7 GO:0030018 Z disc(GO:0030018)
0.1 7.1 GO:0031526 brush border membrane(GO:0031526)
0.1 0.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.2 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 1.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 3.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.6 GO:0005876 spindle microtubule(GO:0005876)
0.0 9.3 GO:0045177 apical part of cell(GO:0045177)
0.0 0.5 GO:0005771 multivesicular body(GO:0005771)
0.0 0.8 GO:0090544 BAF-type complex(GO:0090544)
0.0 1.2 GO:0005776 autophagosome(GO:0005776)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 7.1 GO:0030492 hemoglobin binding(GO:0030492)
0.7 4.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 5.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.4 1.1 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637)
0.3 9.3 GO:0042805 actinin binding(GO:0042805)
0.3 5.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 1.1 GO:0003680 AT DNA binding(GO:0003680)
0.2 0.9 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.2 0.6 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.2 4.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 5.4 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 4.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 2.0 GO:0030332 cyclin binding(GO:0030332)
0.0 2.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 1.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 2.2 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0044548 S100 protein binding(GO:0044548)
0.0 2.6 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 2.1 GO:0051015 actin filament binding(GO:0051015)
0.0 5.7 GO:0005198 structural molecule activity(GO:0005198)