Motif ID: Irx6_Irx2_Irx3

Z-value: 0.900

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx2mm10_v2_chr13_+_72628831_72628971-0.364.8e-03Click!
Irx6mm10_v2_chr8_+_92674289_92674289-0.265.1e-02Click!
Irx3mm10_v2_chr8_-_91801547_91801560-0.123.7e-01Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 17.023 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr10_+_26229707 5.330 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr16_+_17146937 5.100 ENSMUST00000115706.1
ENSMUST00000069064.4
 Ydjc

YdjC homolog (bacterial)

chr10_-_29699379 4.442 ENSMUST00000092620.4
 Gm10275
predicted pseudogene 10275
chr2_-_67433181 4.434 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr2_-_98667264 3.554 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr10_-_125328957 3.279 ENSMUST00000063318.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr7_-_103843154 2.774 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr8_+_129118043 2.730 ENSMUST00000108744.1
 1700008F21Rik
RIKEN cDNA 1700008F21 gene
chr7_+_140763739 2.620 ENSMUST00000026552.7
 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr2_-_169587745 2.612 ENSMUST00000109160.2
 Gm11011
predicted gene 11011
chr8_+_36489191 2.572 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr11_-_76399107 2.380 ENSMUST00000021204.3
 Nxn
nucleoredoxin
chr2_-_169405435 2.380 ENSMUST00000131509.1
 4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr9_-_112232449 2.374 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr2_-_119271202 2.334 ENSMUST00000037360.7
 Rhov
ras homolog gene family, member V
chr6_-_48708206 2.317 ENSMUST00000119315.1
ENSMUST00000053661.4
 Gimap6

GTPase, IMAP family member 6

chr17_-_57839233 2.255 ENSMUST00000095218.3
 Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chr9_+_64173364 2.153 ENSMUST00000034966.7
 Rpl4
ribosomal protein L4
chr6_+_149130170 2.031 ENSMUST00000087348.3
 Gm10203
predicted gene 10203

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 17.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.8 3.3 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.6 2.8 GO:0015671 oxygen transport(GO:0015671)
0.2 2.7 GO:0017144 drug metabolic process(GO:0017144)
0.0 2.6 GO:0008033 tRNA processing(GO:0008033)
0.1 2.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 2.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 2.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 2.0 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 2.0 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.5 1.8 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.6 1.7 GO:0072008 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.0 1.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.7 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 1.7 GO:0048515 spermatid differentiation(GO:0048515)
0.3 1.6 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 1.6 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 1.6 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.1 1.6 GO:0006958 complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 17.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 6.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.5 3.9 GO:0005833 hemoglobin complex(GO:0005833)
0.0 2.6 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.2 2.4 GO:0005687 U4 snRNP(GO:0005687)
0.1 2.2 GO:0031672 A band(GO:0031672)
0.3 2.0 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.7 GO:0005581 collagen trimer(GO:0005581)
0.5 1.6 GO:0043512 inhibin A complex(GO:0043512)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.5 1.4 GO:0000801 central element(GO:0000801)
0.0 1.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.1 1.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.1 GO:0031526 brush border membrane(GO:0031526)
0.0 1.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 1.0 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.9 GO:0005964 phosphorylase kinase complex(GO:0005964)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 15.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 5.1 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0 4.6 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 3.9 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.8 3.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 3.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 2.6 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.6 2.4 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 2.4 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.3 2.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 2.2 GO:0008097 5S rRNA binding(GO:0008097)
0.2 2.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 1.8 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 1.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 1.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.2 1.4 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 1.4 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.4 1.3 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)