Motif ID: Isl2

Z-value: 0.687


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 180 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_12718496 5.872 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr10_-_77166545 5.614 ENSMUST00000081654.6
 Col18a1
collagen, type XVIII, alpha 1
chr9_+_72806874 4.531 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr12_-_10900296 4.211 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr9_-_100506844 3.716 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr17_-_48432723 3.604 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr14_+_27039001 3.582 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr16_-_76403673 3.500 ENSMUST00000052867.7
 Gm9843
predicted gene 9843
chr4_+_3940747 3.427 ENSMUST00000119403.1
 Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr1_-_163289214 3.420 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chrX_+_96455359 3.091 ENSMUST00000033553.7
 Heph
hephaestin
chr8_-_61902669 2.847 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr4_+_136172367 2.843 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chrX_+_136245065 2.827 ENSMUST00000048687.4
 Wbp5
WW domain binding protein 5
chr17_+_17402672 2.819 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr11_+_94327984 2.802 ENSMUST00000107818.2
ENSMUST00000051221.6
 Ankrd40

ankyrin repeat domain 40

chr1_-_128102412 2.579 ENSMUST00000112538.1
ENSMUST00000086614.5
 Zranb3

zinc finger, RAN-binding domain containing 3

chr9_+_108560422 2.518 ENSMUST00000081111.8
 Impdh2
inosine 5'-phosphate dehydrogenase 2
chr17_-_56005566 2.445 ENSMUST00000043785.6
 Stap2
signal transducing adaptor family member 2
chr17_+_20570362 2.424 ENSMUST00000095633.3
 Gm5145
predicted pseudogene 5145

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 5.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 5.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.4 4.3 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.2 4.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.9 3.7 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.2 3.6 GO:0080111 DNA demethylation(GO:0080111)
0.3 3.4 GO:0048664 neuron fate determination(GO:0048664)
0.2 3.1 GO:0006825 copper ion transport(GO:0006825)
0.4 2.8 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.2 2.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 2.8 GO:0097352 autophagosome maturation(GO:0097352)
0.9 2.6 GO:0036292 DNA rewinding(GO:0036292)
0.4 2.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 2.2 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 2.1 GO:0007530 sex determination(GO:0007530)
0.0 2.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.4 2.0 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.0 2.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.3 1.9 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.6 1.8 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 5.6 GO:0005581 collagen trimer(GO:0005581)
0.0 5.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 3.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 3.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 2.9 GO:0043596 nuclear replication fork(GO:0043596)
0.1 2.8 GO:0002102 podosome(GO:0002102)
0.0 2.7 GO:0016459 myosin complex(GO:0016459)
0.5 2.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.4 2.0 GO:0070826 paraferritin complex(GO:0070826)
0.3 1.9 GO:0001740 Barr body(GO:0001740)
0.0 1.9 GO:0000776 kinetochore(GO:0000776)
0.4 1.5 GO:0060187 cell pole(GO:0060187)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.5 GO:0070469 respiratory chain(GO:0070469)
0.5 1.4 GO:0036156 inner dynein arm(GO:0036156)
0.0 1.4 GO:0012505 endomembrane system(GO:0012505)
0.0 1.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.3 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0005198 structural molecule activity(GO:0005198)
1.2 5.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
1.4 4.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 3.8 GO:0003777 microtubule motor activity(GO:0003777)
0.6 3.7 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
1.2 3.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 3.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 3.4 GO:0071837 HMG box domain binding(GO:0071837)
0.6 3.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.7 GO:0050699 WW domain binding(GO:0050699)
0.2 2.6 GO:0036310 annealing helicase activity(GO:0036310)
0.6 2.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 2.3 GO:0001047 core promoter binding(GO:0001047)
0.4 2.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 2.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 2.0 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 2.0 GO:0003774 motor activity(GO:0003774)
0.2 1.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.6 GO:0016415 octanoyltransferase activity(GO:0016415)