Motif ID: Isl2
Z-value: 0.687
Transcription factors associated with Isl2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Isl2 | ENSMUSG00000032318.6 | Isl2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 5.9 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 1.4 | 4.3 | GO:0015938 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) |
| 0.9 | 3.7 | GO:1903898 | positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898) |
| 0.9 | 2.6 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.6 | 1.8 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.5 | 1.6 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.5 | 1.5 | GO:0060489 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.5 | 1.4 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.4 | 1.3 | GO:0071384 | cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385) |
| 0.4 | 2.5 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.4 | 2.8 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 0.4 | 2.0 | GO:0015692 | vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) |
| 0.4 | 1.1 | GO:0009193 | pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048) |
| 0.4 | 1.1 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.3 | 1.0 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) regulation of vascular wound healing(GO:0061043) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) |
| 0.3 | 1.9 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
| 0.3 | 2.2 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.3 | 5.3 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.3 | 3.4 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.2 | 0.9 | GO:0019287 | isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490) |
| 0.2 | 3.6 | GO:0080111 | DNA demethylation(GO:0080111) |
| 0.2 | 1.5 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.2 | 1.1 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.2 | 2.8 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 1.1 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.2 | 0.5 | GO:1902915 | progesterone receptor signaling pathway(GO:0050847) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.2 | 3.1 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.2 | 1.7 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.2 | 0.9 | GO:0036337 | Fas signaling pathway(GO:0036337) |
| 0.2 | 1.0 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.2 | 4.3 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.2 | 1.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.1 | 0.5 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.1 | 0.4 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.1 | 0.8 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
| 0.1 | 1.0 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 2.8 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.1 | 0.8 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.1 | 2.1 | GO:0007530 | sex determination(GO:0007530) |
| 0.1 | 0.6 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 0.7 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.1 | 1.1 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.5 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.1 | 0.5 | GO:0045835 | meiotic cell cycle checkpoint(GO:0033313) negative regulation of meiotic nuclear division(GO:0045835) |
| 0.1 | 1.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.3 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.1 | 0.2 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.0 | 1.1 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.8 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.0 | 0.7 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.0 | 0.9 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.0 | 0.6 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.0 | 0.1 | GO:0045852 | pH elevation(GO:0045852) intracellular pH elevation(GO:0051454) |
| 0.0 | 2.0 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 0.7 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
| 0.0 | 1.0 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.0 | 1.3 | GO:0010390 | histone monoubiquitination(GO:0010390) |
| 0.0 | 0.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.0 | 0.3 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.0 | 0.3 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.0 | 2.1 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 1.3 | GO:0019915 | lipid storage(GO:0019915) |
| 0.0 | 0.6 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
| 0.0 | 0.2 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 1.0 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.0 | 1.0 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 0.3 | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169) |
| 0.0 | 1.4 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
| 0.0 | 0.2 | GO:0010867 | positive regulation of triglyceride biosynthetic process(GO:0010867) positive regulation of triglyceride metabolic process(GO:0090208) |
| 0.0 | 1.4 | GO:0008033 | tRNA processing(GO:0008033) |
| 0.0 | 0.5 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.0 | 0.1 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.0 | 0.3 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.2 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.5 | 1.4 | GO:0036156 | inner dynein arm(GO:0036156) |
| 0.4 | 2.0 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.4 | 1.5 | GO:0060187 | cell pole(GO:0060187) |
| 0.3 | 3.7 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.3 | 1.9 | GO:0001740 | Barr body(GO:0001740) |
| 0.3 | 1.1 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567) |
| 0.2 | 0.8 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.1 | 0.8 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 2.8 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.0 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.1 | 1.0 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 3.3 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 0.6 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.1 | 0.2 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.1 | 0.5 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.1 | 5.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 2.9 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.1 | 0.5 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.0 | 1.4 | GO:0012505 | endomembrane system(GO:0012505) |
| 0.0 | 2.7 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.5 | GO:0048188 | MLL3/4 complex(GO:0044666) Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 6.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.5 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.4 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.1 | GO:0071438 | NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438) |
| 0.0 | 1.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 1.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.0 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.5 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 0.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 5.3 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 1.9 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 0.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.7 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.3 | GO:0015030 | Cajal body(GO:0015030) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.3 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 1.2 | 3.6 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 1.2 | 5.9 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.6 | 2.5 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.6 | 3.7 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.6 | 3.1 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.4 | 2.2 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.4 | 2.0 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.4 | 1.1 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.2 | 1.5 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.2 | 2.6 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.2 | 0.8 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.2 | 1.1 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.2 | 1.8 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 1.0 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 1.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 0.9 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.1 | 0.5 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.1 | 3.6 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 0.1 | 3.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 1.0 | GO:0004889 | acetylcholine-activated cation-selective channel activity(GO:0004889) |
| 0.1 | 2.1 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.7 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.1 | 1.1 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 2.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 1.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.1 | 2.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 3.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 0.8 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.0 | 0.7 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 1.6 | GO:0016415 | octanoyltransferase activity(GO:0016415) |
| 0.0 | 0.3 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.0 | 1.0 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 2.0 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.4 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.0 | 0.5 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.1 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.0 | 0.8 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.2 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.0 | 0.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.5 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.2 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.9 | GO:0016776 | phosphotransferase activity, phosphate group as acceptor(GO:0016776) |
| 0.0 | 1.5 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 1.4 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 1.1 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 8.1 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 2.3 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.3 | GO:0005521 | lamin binding(GO:0005521) |
