Motif ID: Klf1

Z-value: 2.794


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_84901992-0.471.7e-04Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_46179929 28.686 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr7_+_44310213 26.270 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr11_+_104231390 24.053 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr6_+_5725639 23.933 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr11_+_104231515 22.446 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr10_-_81025521 21.876 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr15_+_83791939 21.824 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr11_+_104231465 21.700 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr5_-_139325616 21.688 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr6_+_103510874 21.395 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr8_+_84723003 20.283 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr7_-_103813913 19.974 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr2_-_162661075 19.422 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr10_+_127078886 18.194 ENSMUST00000039259.6
 Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr10_+_106470281 17.945 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr10_-_81472859 17.824 ENSMUST00000147524.1
ENSMUST00000119060.1
 Celf5

CUGBP, Elav-like family member 5

chr5_+_117781017 16.834 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr12_-_4841583 15.512 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr17_+_3326552 15.500 ENSMUST00000169838.1
 Tiam2
T cell lymphoma invasion and metastasis 2
chr8_+_93810832 15.078 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 508 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.2 99.0 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
3.4 47.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.7 34.6 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
1.4 33.9 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
3.7 33.7 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.8 31.9 GO:0035640 exploration behavior(GO:0035640)
0.5 31.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 29.9 GO:0071805 potassium ion transmembrane transport(GO:0071805)
1.3 27.5 GO:0016082 synaptic vesicle priming(GO:0016082)
8.8 26.3 GO:0046959 habituation(GO:0046959)
3.4 24.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
1.9 22.8 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
1.6 22.7 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.8 21.6 GO:0010107 potassium ion import(GO:0010107)
0.7 21.5 GO:0009268 response to pH(GO:0009268)
0.8 21.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
1.0 19.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 19.5 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.5 18.9 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 18.9 GO:0050890 cognition(GO:0050890)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 100.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 94.9 GO:0045211 postsynaptic membrane(GO:0045211)
7.5 75.4 GO:0045298 tubulin complex(GO:0045298)
0.5 63.4 GO:0008021 synaptic vesicle(GO:0008021)
1.3 55.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 41.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 36.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.9 33.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
8.1 32.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 31.2 GO:0031225 anchored component of membrane(GO:0031225)
0.6 30.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 28.6 GO:0030425 dendrite(GO:0030425)
0.2 27.3 GO:0005802 trans-Golgi network(GO:0005802)
0.6 26.5 GO:0031941 filamentous actin(GO:0031941)
0.8 23.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
1.2 22.7 GO:0034704 calcium channel complex(GO:0034704)
0.9 22.6 GO:0071565 nBAF complex(GO:0071565)
0.4 21.1 GO:0005871 kinesin complex(GO:0005871)
3.0 20.9 GO:0044326 dendritic spine neck(GO:0044326)
1.2 19.5 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 355 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 90.3 GO:0005096 GTPase activator activity(GO:0005096)
0.4 78.6 GO:0003924 GTPase activity(GO:0003924)
3.3 74.8 GO:0034185 apolipoprotein binding(GO:0034185)
1.3 37.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
8.9 35.8 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
8.1 32.3 GO:0031720 haptoglobin binding(GO:0031720)
2.9 31.5 GO:0038191 neuropilin binding(GO:0038191)
0.7 30.5 GO:0005267 potassium channel activity(GO:0005267)
1.6 28.0 GO:0050811 GABA receptor binding(GO:0050811)
2.0 27.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 26.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.2 25.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.4 25.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
1.6 24.1 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.9 23.6 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.6 23.5 GO:0001540 beta-amyloid binding(GO:0001540)
4.6 23.1 GO:0045503 dynein light chain binding(GO:0045503)
0.3 23.1 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.4 21.8 GO:0030276 clathrin binding(GO:0030276)
0.9 21.5 GO:0003785 actin monomer binding(GO:0003785)