Motif ID: Klf12_Klf14_Sp4

Z-value: 0.749

Transcription factors associated with Klf12_Klf14_Sp4:

Gene SymbolEntrez IDGene Name
Klf12 ENSMUSG00000072294.4 Klf12
Klf14 ENSMUSG00000073209.3 Klf14
Sp4 ENSMUSG00000025323.9 Sp4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp4mm10_v2_chr12_-_118301429_1183014580.047.6e-01Click!
Klf12mm10_v2_chr14_-_100149764_100149764-0.019.3e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Klf12_Klf14_Sp4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78322965 6.687 ENSMUST00000017534.8
Aldoc
aldolase C, fructose-bisphosphate
chr9_+_80165013 4.031 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6

myosin VI

chr9_+_80165079 3.852 ENSMUST00000184480.1
Myo6
myosin VI
chr5_-_99252839 3.283 ENSMUST00000168092.1
ENSMUST00000031276.8
Rasgef1b

RasGEF domain family, member 1B

chr5_-_109558957 3.056 ENSMUST00000044579.7
Crlf2
cytokine receptor-like factor 2
chr10_-_59951753 2.846 ENSMUST00000020308.3
Ddit4
DNA-damage-inducible transcript 4
chr2_+_172345565 2.843 ENSMUST00000028995.4
Fam210b
family with sequence similarity 210, member B
chr13_+_92611119 2.821 ENSMUST00000049488.7
Serinc5
serine incorporator 5
chr2_-_30474199 2.787 ENSMUST00000065134.2
Ier5l
immediate early response 5-like
chr11_-_53430779 2.699 ENSMUST00000061326.4
ENSMUST00000109021.3
Uqcrq

ubiquinol-cytochrome c reductase, complex III subunit VII

chr5_-_31241215 2.446 ENSMUST00000068997.3
Gm9970
predicted gene 9970
chr13_-_49215978 2.359 ENSMUST00000048946.6
1110007C09Rik
RIKEN cDNA 1110007C09 gene
chr15_-_58076456 2.247 ENSMUST00000070143.6
ENSMUST00000110168.1
Zhx1

zinc fingers and homeoboxes 1

chr7_-_16286744 2.118 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
Ccdc9


coiled-coil domain containing 9


chr4_-_120287349 2.088 ENSMUST00000102656.3
Foxo6
forkhead box O6
chr7_-_16273692 2.070 ENSMUST00000169612.1
Prr24
proline rich 24
chr10_-_59221757 2.060 ENSMUST00000165971.1
Sept10
septin 10
chr16_-_67620880 2.045 ENSMUST00000114292.1
ENSMUST00000120898.1
Cadm2

cell adhesion molecule 2

chr7_-_63938862 2.044 ENSMUST00000063694.8
Klf13
Kruppel-like factor 13
chr4_-_129121699 2.037 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
Hpca


hippocalcin



Gene overrepresentation in biological_process category:

Showing 1 to 20 of 526 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.3 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.6 6.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.7 5.1 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 2.8 GO:0045820 negative regulation of glycolytic process(GO:0045820)
0.7 2.7 GO:0009597 detection of virus(GO:0009597)
0.5 2.7 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.2 2.6 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 2.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 2.5 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.5 2.4 GO:1904683 regulation of metalloendopeptidase activity(GO:1904683)
0.6 2.3 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 2.3 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.2 2.2 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 2.2 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 2.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 2.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 1.9 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.2 1.9 GO:1902669 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of axon guidance(GO:1902669)
0.1 1.9 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.6 1.8 GO:0035928 rRNA import into mitochondrion(GO:0035928)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.5 4.9 GO:0044327 dendritic spine head(GO:0044327)
0.0 4.7 GO:0000139 Golgi membrane(GO:0000139)
0.1 4.4 GO:0044815 DNA packaging complex(GO:0044815)
0.1 3.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 3.8 GO:0032994 protein-lipid complex(GO:0032994)
0.0 3.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.7 GO:0070469 respiratory chain(GO:0070469)
0.0 2.6 GO:0005769 early endosome(GO:0005769)
0.6 2.5 GO:0045098 type III intermediate filament(GO:0045098)
0.0 2.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 2.3 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.1 2.0 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.9 GO:0042383 sarcolemma(GO:0042383)
0.2 1.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 1.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.4 1.6 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 1.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.5 GO:0000137 Golgi cis cisterna(GO:0000137)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 330 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.1 GO:0051015 actin filament binding(GO:0051015)
1.1 6.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 5.0 GO:0005125 cytokine activity(GO:0005125)
0.0 3.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 3.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.4 2.8 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.3 2.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 2.7 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 2.6 GO:0017124 SH3 domain binding(GO:0017124)
0.8 2.3 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.0 2.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 2.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.3 2.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 2.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 1.8 GO:0036361 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.4 1.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.4 1.8 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.2 1.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 1.8 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)