Motif ID: Klf16_Sp8

Z-value: 1.116

Transcription factors associated with Klf16_Sp8:

Gene SymbolEntrez IDGene Name
Klf16 ENSMUSG00000035397.8 Klf16
Sp8 ENSMUSG00000048562.6 Sp8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf16mm10_v2_chr10_-_80577285_80577327-0.563.4e-06Click!
Sp8mm10_v2_chr12_+_118846329_1188463290.462.9e-04Click!


Activity profile for motif Klf16_Sp8.

activity profile for motif Klf16_Sp8


Sorted Z-values histogram for motif Klf16_Sp8

Sorted Z-values for motif Klf16_Sp8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf16_Sp8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_38107490 11.488 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr15_+_25622525 11.300 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr7_-_144939823 9.396 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr17_-_32166879 9.074 ENSMUST00000087723.3
 Notch3
notch 3
chr12_+_103314944 8.791 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr19_+_53142756 8.648 ENSMUST00000050096.7
 Add3
adducin 3 (gamma)
chr17_-_70851189 8.548 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr18_+_82914632 8.249 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr18_+_49979514 8.157 ENSMUST00000179937.1
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr8_+_105518736 8.123 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr11_-_102946688 7.983 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr5_-_144358103 7.972 ENSMUST00000055190.7
 Baiap2l1
BAI1-associated protein 2-like 1
chr18_+_49979427 7.938 ENSMUST00000148989.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr4_-_55532453 7.802 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)

chr9_-_119578981 7.750 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr7_-_4752972 7.569 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr7_+_45216671 7.330 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr4_+_111720187 7.316 ENSMUST00000084354.3
 Spata6
spermatogenesis associated 6
chr19_+_55741810 7.250 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr19_-_45742873 7.027 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,243 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 27.2 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.7 20.8 GO:0006270 DNA replication initiation(GO:0006270)
2.9 20.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.5 18.4 GO:0044458 motile cilium assembly(GO:0044458)
0.3 18.1 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.4 16.9 GO:0071230 cellular response to amino acid stimulus(GO:0071230)
0.6 16.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
1.0 16.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.6 16.2 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.7 15.8 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
1.9 15.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.7 14.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.3 14.6 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 13.5 GO:0051028 mRNA transport(GO:0051028)
0.6 13.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.5 12.9 GO:0034508 centromere complex assembly(GO:0034508)
1.1 12.6 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.9 12.6 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
3.1 12.4 GO:0046469 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
3.1 12.3 GO:0015888 thiamine transport(GO:0015888)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 390 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 117.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 81.4 GO:0005615 extracellular space(GO:0005615)
0.0 53.5 GO:0005654 nucleoplasm(GO:0005654)
0.9 42.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 25.0 GO:0005844 polysome(GO:0005844)
0.1 23.8 GO:0005681 spliceosomal complex(GO:0005681)
0.5 23.6 GO:0000791 euchromatin(GO:0000791)
0.5 21.0 GO:0005876 spindle microtubule(GO:0005876)
0.1 19.6 GO:0000790 nuclear chromatin(GO:0000790)
0.3 18.9 GO:0005581 collagen trimer(GO:0005581)
1.6 17.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.8 16.6 GO:0016580 Sin3 complex(GO:0016580)
0.1 16.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 16.2 GO:0005925 focal adhesion(GO:0005925)
0.1 15.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 15.8 GO:0005814 centriole(GO:0005814)
0.2 13.6 GO:0005643 nuclear pore(GO:0005643)
0.2 13.2 GO:0032432 actin filament bundle(GO:0032432)
1.8 12.9 GO:0000796 condensin complex(GO:0000796)
0.2 12.2 GO:0044291 cell-cell contact zone(GO:0044291)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 660 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 98.3 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
0.7 27.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 23.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.9 19.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.9 19.0 GO:0070410 co-SMAD binding(GO:0070410)
1.3 18.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.7 17.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.7 17.3 GO:0070064 proline-rich region binding(GO:0070064)
1.0 16.5 GO:0017166 vinculin binding(GO:0017166)
1.7 14.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 14.8 GO:0003682 chromatin binding(GO:0003682)
2.8 14.2 GO:0032027 myosin light chain binding(GO:0032027)
3.5 14.0 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.2 14.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 13.9 GO:0035064 methylated histone binding(GO:0035064)
0.7 13.8 GO:0035198 miRNA binding(GO:0035198)
0.2 13.6 GO:0005179 hormone activity(GO:0005179)
0.0 13.6 GO:0044822 poly(A) RNA binding(GO:0044822)
0.1 13.5 GO:0042393 histone binding(GO:0042393)
1.3 13.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)