Motif ID: Klf3

Z-value: 0.313


Transcription factors associated with Klf3:

Gene SymbolEntrez IDGene Name
Klf3 ENSMUSG00000029178.8 Klf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf3mm10_v2_chr5_+_64812336_64812350-0.556.6e-06Click!


Activity profile for motif Klf3.

activity profile for motif Klf3


Sorted Z-values histogram for motif Klf3

Sorted Z-values for motif Klf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_72824482 1.194 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_+_107511489 1.124 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 1.076 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_102251852 0.972 ENSMUST00000101336.3
ENSMUST00000136277.1
 Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chrX_-_102252154 0.869 ENSMUST00000050551.3
 Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr11_+_99041237 0.819 ENSMUST00000017637.6
 Igfbp4
insulin-like growth factor binding protein 4
chr3_+_135438722 0.693 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr7_+_82337218 0.670 ENSMUST00000173828.1
 Adamtsl3
ADAMTS-like 3
chr11_+_68968107 0.650 ENSMUST00000102606.3
ENSMUST00000018884.5
 Slc25a35

solute carrier family 25, member 35

chr3_+_90080442 0.570 ENSMUST00000127955.1
 Tpm3
tropomyosin 3, gamma
chr3_+_90079540 0.487 ENSMUST00000029549.9
ENSMUST00000118566.1
ENSMUST00000119158.1
 Tpm3


tropomyosin 3, gamma


chrX_-_74246534 0.402 ENSMUST00000101454.2
ENSMUST00000033699.6
 Flna

filamin, alpha

chr12_+_87026286 0.383 ENSMUST00000146292.1
 Tmem63c
transmembrane protein 63c
chr12_+_87026564 0.377 ENSMUST00000110187.1
ENSMUST00000156162.1
 Tmem63c

transmembrane protein 63c

chr7_-_17027853 0.360 ENSMUST00000003183.5
 Ppp5c
protein phosphatase 5, catalytic subunit
chr9_-_67539392 0.353 ENSMUST00000039662.8
 Tln2
talin 2
chr3_-_89089955 0.351 ENSMUST00000166687.1
 Rusc1
RUN and SH3 domain containing 1
chr7_-_17027807 0.322 ENSMUST00000142597.1
 Ppp5c
protein phosphatase 5, catalytic subunit
chr7_-_103827922 0.314 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr1_+_86064619 0.314 ENSMUST00000027432.8
 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr4_-_41774097 0.259 ENSMUST00000108036.1
ENSMUST00000173865.1
ENSMUST00000108037.2
ENSMUST00000108032.2
 Ccl27a



chemokine (C-C motif) ligand 27A



chrX_-_74246364 0.240 ENSMUST00000130007.1
 Flna
filamin, alpha
chr19_-_53390559 0.179 ENSMUST00000025997.5
 Smndc1
survival motor neuron domain containing 1
chr5_+_137630116 0.161 ENSMUST00000175968.1
 Lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr7_-_4149781 0.128 ENSMUST00000058358.6
 Leng9
leukocyte receptor cluster (LRC) member 9
chr5_+_124541296 0.126 ENSMUST00000124529.1
 Tmed2
transmembrane emp24 domain trafficking protein 2
chr1_+_131867224 0.103 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr10_+_93488766 0.050 ENSMUST00000129421.1
 Hal
histidine ammonia lyase
chr3_+_89266552 0.034 ENSMUST00000040824.1
 Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr9_+_109931863 0.020 ENSMUST00000165876.1
 Map4
microtubule-associated protein 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.1 2.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 0.3 GO:0071677 positive regulation of mononuclear cell migration(GO:0071677)
0.1 0.6 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 2.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.1 GO:0006547 histidine metabolic process(GO:0006547)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0031523 Myb complex(GO:0031523)
0.1 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.1 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 1.8 GO:0050693 LBD domain binding(GO:0050693)
0.2 0.6 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 0.3 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0016841 ammonia-lyase activity(GO:0016841)