Motif ID: Klf4_Sp3

Z-value: 1.678

Transcription factors associated with Klf4_Sp3:

Gene SymbolEntrez IDGene Name
Klf4 ENSMUSG00000003032.8 Klf4
Sp3 ENSMUSG00000027109.10 Sp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp3mm10_v2_chr2_-_72980402_72980471-0.783.6e-13Click!
Klf4mm10_v2_chr4_-_55532453_55532485-0.076.1e-01Click!


Activity profile for motif Klf4_Sp3.

activity profile for motif Klf4_Sp3


Sorted Z-values histogram for motif Klf4_Sp3

Sorted Z-values for motif Klf4_Sp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf4_Sp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_105518736 26.009 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr12_+_17690793 18.479 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr7_-_38107490 18.467 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr4_+_124986430 17.787 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr4_-_117133953 16.580 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr7_-_143460989 16.549 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chrX_+_73639414 15.596 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr17_-_70851189 15.123 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr5_-_144358103 14.832 ENSMUST00000055190.7
 Baiap2l1
BAI1-associated protein 2-like 1
chrX_-_106485214 14.828 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr7_+_29289300 14.646 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr8_+_87473116 14.628 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr2_-_92370999 14.367 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr19_-_45742873 14.044 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr2_-_92370968 13.932 ENSMUST00000176774.1
 Gyltl1b
glycosyltransferase-like 1B
chr4_-_129239165 13.536 ENSMUST00000097873.3
 C77080
expressed sequence C77080
chr11_+_32276893 13.236 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr2_-_92371039 13.170 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B
chr17_+_57249450 13.147 ENSMUST00000019631.9
 Trip10
thyroid hormone receptor interactor 10
chr4_-_107253513 13.117 ENSMUST00000030360.4
 Lrrc42
leucine rich repeat containing 42

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,210 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 45.1 GO:0006412 translation(GO:0006412)
2.2 43.5 GO:0038092 nodal signaling pathway(GO:0038092)
1.2 40.6 GO:0006270 DNA replication initiation(GO:0006270)
2.8 39.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
2.6 35.8 GO:0051764 actin crosslink formation(GO:0051764)
1.2 34.0 GO:0006783 heme biosynthetic process(GO:0006783)
6.2 30.8 GO:0015671 oxygen transport(GO:0015671)
1.7 29.3 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.3 28.4 GO:0006364 rRNA processing(GO:0006364)
0.7 26.7 GO:0043966 histone H3 acetylation(GO:0043966)
0.3 26.1 GO:0008033 tRNA processing(GO:0008033)
6.4 25.7 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
1.1 23.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
2.9 23.4 GO:0008343 adult feeding behavior(GO:0008343)
1.2 23.2 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.8 22.9 GO:0006284 base-excision repair(GO:0006284)
7.5 22.5 GO:1904274 tricellular tight junction assembly(GO:1904274)
5.6 22.5 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
4.3 21.7 GO:0006177 GMP biosynthetic process(GO:0006177)
4.3 21.6 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 420 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 142.8 GO:0005634 nucleus(GO:0005634)
0.1 116.8 GO:0005829 cytosol(GO:0005829)
0.2 58.9 GO:0005667 transcription factor complex(GO:0005667)
0.8 58.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 54.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.6 49.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.5 49.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.1 48.5 GO:0008180 COP9 signalosome(GO:0008180)
1.0 48.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 40.8 GO:0005730 nucleolus(GO:0005730)
0.9 40.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
4.5 36.1 GO:0005833 hemoglobin complex(GO:0005833)
0.7 33.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.3 31.6 GO:0030914 STAGA complex(GO:0030914)
0.4 26.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 26.3 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
2.1 25.7 GO:0030057 desmosome(GO:0030057)
2.3 25.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
4.1 24.7 GO:0061689 tricellular tight junction(GO:0061689)
0.2 24.6 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 664 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 164.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 48.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.7 44.3 GO:0002039 p53 binding(GO:0002039)
0.9 41.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
8.1 40.5 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.7 39.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.8 38.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
1.0 36.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.1 35.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 35.6 GO:0003682 chromatin binding(GO:0003682)
0.6 34.1 GO:0070491 repressing transcription factor binding(GO:0070491)
1.5 33.6 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
2.3 31.9 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.4 31.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
6.2 30.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 30.4 GO:0044822 poly(A) RNA binding(GO:0044822)
1.4 29.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.6 29.2 GO:0003743 translation initiation factor activity(GO:0003743)
2.2 29.0 GO:0017070 U6 snRNA binding(GO:0017070)
1.3 28.6 GO:0070410 co-SMAD binding(GO:0070410)