Motif ID: Klf7

Z-value: 0.591


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64121456_641214910.498.5e-05Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_156312470 6.005 ENSMUST00000079125.6
Scand1
SCAN domain-containing 1
chr6_-_88875035 4.812 ENSMUST00000145944.1
Podxl2
podocalyxin-like 2
chrY_+_897782 4.169 ENSMUST00000055032.7
Kdm5d
lysine (K)-specific demethylase 5D
chr3_+_28263205 3.764 ENSMUST00000159236.2
Tnik
TRAF2 and NCK interacting kinase
chr5_-_137741601 3.543 ENSMUST00000119498.1
ENSMUST00000061789.7
Nyap1

neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

chr5_+_137778849 3.309 ENSMUST00000126126.1
ENSMUST00000031739.4
Ppp1r35

protein phosphatase 1, regulatory subunit 35

chr6_-_88874597 3.186 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
Podxl2


podocalyxin-like 2


chr12_-_4592927 3.027 ENSMUST00000170816.1
Gm3625
predicted gene 3625
chr7_-_74013676 3.015 ENSMUST00000026896.4
St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr4_+_107830958 2.986 ENSMUST00000106731.2
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr12_+_49382791 2.912 ENSMUST00000179669.1
Foxg1
forkhead box G1
chr12_+_49383007 2.587 ENSMUST00000021333.3
Foxg1
forkhead box G1
chr15_-_102722150 2.272 ENSMUST00000023818.3
Calcoco1
calcium binding and coiled coil domain 1
chr15_-_102722120 2.143 ENSMUST00000171838.1
Calcoco1
calcium binding and coiled coil domain 1
chr7_-_28766469 2.001 ENSMUST00000085851.5
ENSMUST00000032815.4
Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr6_+_52714219 1.903 ENSMUST00000138040.1
ENSMUST00000129660.1
Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr15_+_30172570 1.881 ENSMUST00000081728.5
Ctnnd2
catenin (cadherin associated protein), delta 2
chr3_+_106721893 1.623 ENSMUST00000106736.2
ENSMUST00000154973.1
ENSMUST00000131330.1
ENSMUST00000150513.1
Lrif1



ligand dependent nuclear receptor interacting factor 1



chr6_+_125039760 1.512 ENSMUST00000140131.1
ENSMUST00000032480.7
Ing4

inhibitor of growth family, member 4

chr18_+_67133713 1.467 ENSMUST00000076605.7
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr11_-_61494173 1.444 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
Mapk7


mitogen-activated protein kinase 7


chr5_+_137761680 1.418 ENSMUST00000110983.2
ENSMUST00000031738.4
Tsc22d4

TSC22 domain family, member 4

chr1_-_23383149 1.411 ENSMUST00000027343.5
Ogfrl1
opioid growth factor receptor-like 1
chr3_+_106721672 1.397 ENSMUST00000098750.2
ENSMUST00000130105.1
Lrif1

ligand dependent nuclear receptor interacting factor 1

chr4_+_139622842 1.315 ENSMUST00000039818.9
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
chr2_-_130424242 1.277 ENSMUST00000089581.4
Pced1a
PC-esterase domain containing 1A
chr2_+_32775769 1.207 ENSMUST00000066352.5
Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr2_-_73892619 1.193 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2

activating transcription factor 2

chr7_+_28766747 1.175 ENSMUST00000170068.1
ENSMUST00000072965.4
Sirt2

sirtuin 2

chr7_-_68749170 1.168 ENSMUST00000118110.1
ENSMUST00000048068.7
Arrdc4

arrestin domain containing 4

chr17_+_24488773 1.086 ENSMUST00000024958.7
Caskin1
CASK interacting protein 1
chr2_-_73892588 1.046 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
Atf2


activating transcription factor 2


chr5_-_34187670 1.007 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr5_-_124187150 0.987 ENSMUST00000161938.1
Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr6_+_52713729 0.961 ENSMUST00000080723.4
ENSMUST00000149588.1
Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr4_+_152178126 0.897 ENSMUST00000075363.3
Acot7
acyl-CoA thioesterase 7
chr9_-_32344237 0.897 ENSMUST00000034533.5
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr2_-_73892530 0.870 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2



activating transcription factor 2



chr2_+_156312589 0.805 ENSMUST00000073942.5
ENSMUST00000109580.1
Cnbd2

cyclic nucleotide binding domain containing 2

chr4_-_87230435 0.761 ENSMUST00000107157.2
Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr8_+_71367210 0.736 ENSMUST00000019169.7
Use1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr8_+_3500451 0.722 ENSMUST00000004683.6
ENSMUST00000160338.1
Mcoln1

mucolipin 1

chr5_-_115348953 0.679 ENSMUST00000040154.8
Cox6a1
cytochrome c oxidase subunit VIa polypeptide 1
chr1_+_171329015 0.674 ENSMUST00000111300.1
Dedd
death effector domain-containing
chr12_-_11436607 0.650 ENSMUST00000072299.5
Vsnl1
visinin-like 1
chr2_-_151973387 0.597 ENSMUST00000109863.1
Fam110a
family with sequence similarity 110, member A
chr8_-_22476809 0.582 ENSMUST00000163774.1
ENSMUST00000033935.8
Smim19

small integral membrane protein 19

chr15_-_89196457 0.565 ENSMUST00000078953.7
Dennd6b
DENN/MADD domain containing 6B
chr11_-_101302206 0.542 ENSMUST00000140706.1
ENSMUST00000170502.1
ENSMUST00000172233.1
ENSMUST00000130916.1
Becn1



beclin 1, autophagy related



chr15_-_98953541 0.526 ENSMUST00000097014.5
Tuba1a
tubulin, alpha 1A
chr11_+_78536355 0.525 ENSMUST00000128788.1
Ift20
intraflagellar transport 20
chr7_+_80261202 0.510 ENSMUST00000117989.1
Ngrn
neugrin, neurite outgrowth associated
chr4_-_132329414 0.471 ENSMUST00000127402.1
ENSMUST00000105962.3
ENSMUST00000030730.7
ENSMUST00000105960.1
Trnau1ap



tRNA selenocysteine 1 associated protein 1



chr1_-_138847579 0.469 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr7_-_141414115 0.467 ENSMUST00000106008.1
Pddc1
Parkinson disease 7 domain containing 1
chr11_+_78536393 0.422 ENSMUST00000050366.8
ENSMUST00000108275.1
Ift20

intraflagellar transport 20

chr2_-_130424673 0.380 ENSMUST00000110277.1
Pced1a
PC-esterase domain containing 1A
chr14_+_79451791 0.377 ENSMUST00000100359.1
Zbtbd6
kelch repeat and BTB (POZ) domain containing 6
chr8_+_3621529 0.339 ENSMUST00000156380.2
Pet100
PET100 homolog (S. cerevisiae)
chr7_+_45154644 0.332 ENSMUST00000153973.1
Pih1d1
PIH1 domain containing 1
chr2_-_156180135 0.319 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
Rbm39




RNA binding motif protein 39




chr1_+_172082796 0.318 ENSMUST00000027833.5
Copa
coatomer protein complex subunit alpha
chr3_+_51224447 0.318 ENSMUST00000023849.8
ENSMUST00000167780.1
Ccrn4l

CCR4 carbon catabolite repression 4-like (S. cerevisiae)

chr7_+_45154297 0.314 ENSMUST00000107813.1
ENSMUST00000125953.1
ENSMUST00000085375.5
ENSMUST00000144597.1
Pih1d1



PIH1 domain containing 1



chr7_+_126976338 0.296 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr5_+_45520221 0.293 ENSMUST00000156481.1
ENSMUST00000119579.1
ENSMUST00000118833.1
Med28


mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)


chr1_+_57406328 0.275 ENSMUST00000027114.5
9430016H08Rik
RIKEN cDNA 9430016H08 gene
chr13_-_67451585 0.238 ENSMUST00000057241.8
ENSMUST00000075255.5
Zfp874a

zinc finger protein 874a

chr1_+_163929765 0.231 ENSMUST00000027876.4
ENSMUST00000170359.1
Scyl3

SCY1-like 3 (S. cerevisiae)

chr19_-_8723356 0.219 ENSMUST00000170157.1
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr7_-_132776855 0.203 ENSMUST00000106168.1
Fam53b
family with sequence similarity 53, member B
chr5_+_3596066 0.201 ENSMUST00000006061.6
ENSMUST00000121291.1
ENSMUST00000142516.1
Pex1


peroxisomal biogenesis factor 1


chr13_+_96542727 0.170 ENSMUST00000077672.4
ENSMUST00000109444.2
Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr11_+_72301613 0.169 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
Xaf1


XIAP associated factor 1


chr8_+_71922810 0.164 ENSMUST00000119003.1
Zfp617
zinc finger protein 617
chr1_+_172082509 0.137 ENSMUST00000135192.1
Copa
coatomer protein complex subunit alpha
chr10_-_86705485 0.134 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr1_-_172082757 0.134 ENSMUST00000003550.4
Ncstn
nicastrin
chr5_-_3596071 0.133 ENSMUST00000121877.1
Rbm48
RNA binding motif protein 48
chr2_+_172550991 0.132 ENSMUST00000170744.1
Tfap2c
transcription factor AP-2, gamma
chr17_+_35916541 0.130 ENSMUST00000087211.2
Ppp1r10
protein phosphatase 1, regulatory subunit 10
chr13_-_14613017 0.121 ENSMUST00000015816.3
Mrpl32
mitochondrial ribosomal protein L32
chr1_+_120121161 0.086 ENSMUST00000027637.6
ENSMUST00000112644.2
ENSMUST00000056038.8
3110009E18Rik


RIKEN cDNA 3110009E18 gene


chr1_-_57406443 0.047 ENSMUST00000160837.1
ENSMUST00000161780.1
Tyw5

tRNA-yW synthesizing protein 5

chr10_+_86705811 0.034 ENSMUST00000061458.7
ENSMUST00000075632.6
BC030307

cDNA sequence BC030307

chr2_+_119047116 0.030 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr1_-_120120937 0.006 ENSMUST00000151708.1
Dbi
diazepam binding inhibitor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0021852 pyramidal neuron migration(GO:0021852)
1.0 3.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.8 4.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.8 3.8 GO:0007256 activation of JNKK activity(GO:0007256)
0.5 8.0 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.5 1.4 GO:0070375 ERK5 cascade(GO:0070375)
0.3 2.0 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.3 3.0 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.3 1.2 GO:0061428 positive regulation of oocyte development(GO:0060282) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.2 0.9 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.2 1.5 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.2 1.3 GO:0006537 glutamate biosynthetic process(GO:0006537) proline biosynthetic process(GO:0006561)
0.2 0.6 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110)
0.2 3.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 1.5 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 0.9 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.7 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.5 GO:1903599 attachment of mitotic spindle microtubules to kinetochore(GO:0051315) positive regulation of mitophagy(GO:1903599)
0.1 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.5 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 0.5 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.3 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.2 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.0 0.7 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.1 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.0 0.2 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 3.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.2 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 3.5 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.5 GO:0030157 pancreatic juice secretion(GO:0030157)
0.0 0.5 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 4.1 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.0 2.1 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 1.9 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 1.4 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.5 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.2 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.8 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.7 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.0 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.2 GO:0016558 protein import into peroxisome matrix(GO:0016558)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:1902636 kinociliary basal body(GO:1902636)
0.2 1.2 GO:0033010 paranodal junction(GO:0033010)
0.1 0.6 GO:0097255 R2TP complex(GO:0097255)
0.1 0.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 3.1 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 7.7 GO:0055037 recycling endosome(GO:0055037)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.6 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 2.8 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.9 GO:0043204 perikaryon(GO:0043204)
0.0 1.5 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 1.0 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.0 GO:0038025 reelin receptor activity(GO:0038025)
0.6 4.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.5 3.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.5 1.5 GO:0050827 toxin receptor binding(GO:0050827)
0.3 1.2 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.3 2.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 1.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.2 0.7 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 4.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 0.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.5 GO:0019172 glyoxalase III activity(GO:0019172)
0.1 2.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 1.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 3.0 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 1.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.6 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 3.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.2 GO:0097001 sphingolipid transporter activity(GO:0046624) ceramide binding(GO:0097001)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 7.8 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 2.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.8 GO:0030552 cAMP binding(GO:0030552)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.5 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)