Motif ID: Klf8

Z-value: 0.746


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.771.0e-12Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 11.145 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr6_-_72788952 5.948 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr19_+_25610533 4.537 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr7_-_127026479 4.458 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr7_-_144939823 4.398 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr4_+_46450892 4.245 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr3_+_87948666 4.034 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr18_+_74442500 3.599 ENSMUST00000074157.6
 Myo5b
myosin VB
chr9_-_8004585 3.460 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr11_+_85832551 3.304 ENSMUST00000000095.6
 Tbx2
T-box 2
chr2_+_172550991 3.288 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr7_-_142657466 3.045 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr3_-_89393294 2.939 ENSMUST00000142119.1
ENSMUST00000029677.8
ENSMUST00000148361.1
 Zbtb7b


zinc finger and BTB domain containing 7B


chr11_-_109473220 2.610 ENSMUST00000070872.6
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr15_+_39006272 2.490 ENSMUST00000179165.1
ENSMUST00000022906.7
 Fzd6

frizzled homolog 6 (Drosophila)

chr7_-_31055594 2.440 ENSMUST00000039909.6
 Fxyd1
FXYD domain-containing ion transport regulator 1
chr5_-_114690974 2.336 ENSMUST00000012028.7
 Gltp
glycolipid transfer protein
chr2_+_27886416 2.232 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr4_-_97778042 2.203 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chrX_-_7967817 2.170 ENSMUST00000033502.7
 Gata1
GATA binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 13.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.0 5.9 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.0 5.9 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.5 5.3 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.9 4.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.4 4.5 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 4.5 GO:0009299 mRNA transcription(GO:0009299)
0.6 4.4 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.4 4.3 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.1 4.3 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.2 3.7 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.9 3.6 GO:0032439 endosome localization(GO:0032439)
0.6 3.5 GO:0060242 contact inhibition(GO:0060242)
1.1 3.3 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
1.1 3.3 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.4 3.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 2.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 2.8 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.9 2.7 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.5 2.7 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.0 GO:0005667 transcription factor complex(GO:0005667)
1.8 5.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 4.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.7 4.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 4.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.8 3.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 3.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 3.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.3 GO:0009897 external side of plasma membrane(GO:0009897)
1.0 2.9 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 2.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.6 GO:0005604 basement membrane(GO:0005604)
0.1 2.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 2.4 GO:0031415 NatA complex(GO:0031415)
0.7 2.2 GO:0005588 collagen type V trimer(GO:0005588)
0.5 2.1 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 2.1 GO:0042555 MCM complex(GO:0042555)
0.3 2.0 GO:0061689 tricellular tight junction(GO:0061689)
0.0 2.0 GO:0005844 polysome(GO:0005844)
0.4 1.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 9.2 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.1 8.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 7.8 GO:0070064 proline-rich region binding(GO:0070064)
0.2 6.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 4.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.7 4.0 GO:0019841 retinol binding(GO:0019841)
0.4 3.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 3.7 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 3.6 GO:0001948 glycoprotein binding(GO:0001948)
1.1 3.4 GO:0005118 sevenless binding(GO:0005118)
0.0 3.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 3.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.7 2.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 2.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.5 2.4 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.8 2.3 GO:0017089 glycolipid transporter activity(GO:0017089)
0.6 2.3 GO:0008142 oxysterol binding(GO:0008142)
0.4 2.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)