Motif ID: Lef1

Z-value: 1.515


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.365.3e-03Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_98169542 13.133 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr10_-_92165159 9.198 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr3_+_102010138 7.414 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr12_-_119238794 7.250 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr1_-_138842429 6.125 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr7_-_144939823 6.054 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr3_-_57575760 5.922 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr8_-_46294592 5.778 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr2_+_70474923 5.704 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr8_+_45507768 5.390 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chr2_+_73271925 5.362 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr3_-_57575907 5.352 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr12_+_52516077 5.259 ENSMUST00000110725.1
 Arhgap5
Rho GTPase activating protein 5
chr4_-_63403330 5.233 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr5_+_75075464 4.968 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr1_+_6734827 4.885 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr7_-_49636847 4.830 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr12_+_76072016 4.596 ENSMUST00000131480.1
 Syne2
spectrin repeat containing, nuclear envelope 2
chr19_+_55742242 4.585 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr8_+_108714644 4.458 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 15.4 GO:0048625 myoblast fate commitment(GO:0048625)
4.4 13.1 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.6 11.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.7 10.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.5 8.8 GO:0021860 pyramidal neuron development(GO:0021860)
2.1 8.5 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.4 7.9 GO:0001967 suckling behavior(GO:0001967)
0.2 7.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.3 7.4 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.3 7.2 GO:0001573 ganglioside metabolic process(GO:0001573)
0.2 7.0 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.9 6.3 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
2.0 6.1 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
1.2 6.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.9 6.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.5 6.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3 5.9 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 5.9 GO:0007018 microtubule-based movement(GO:0007018)
1.1 5.7 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 5.5 GO:2001222 regulation of neuron migration(GO:2001222)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 90.6 GO:0005634 nucleus(GO:0005634)
0.1 46.0 GO:0005667 transcription factor complex(GO:0005667)
1.7 15.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 11.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.5 9.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.4 7.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.6 7.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 6.0 GO:0072686 mitotic spindle(GO:0072686)
0.0 5.9 GO:0005874 microtubule(GO:0005874)
1.4 5.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.1 5.6 GO:0008623 CHRAC(GO:0008623)
0.1 5.4 GO:0005871 kinesin complex(GO:0005871)
0.3 4.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 4.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 3.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 3.6 GO:0000922 spindle pole(GO:0000922)
1.7 3.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 2.8 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 2.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 2.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 77.4 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
1.0 27.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 17.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
4.4 13.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 11.1 GO:0003677 DNA binding(GO:0003677)
0.0 11.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.4 8.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 8.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.6 7.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 7.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 6.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 6.8 GO:0051015 actin filament binding(GO:0051015)
0.4 6.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.9 6.1 GO:0043237 laminin-1 binding(GO:0043237)
0.3 5.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 5.3 GO:0031402 sodium ion binding(GO:0031402)
0.2 5.3 GO:0008432 JUN kinase binding(GO:0008432)
0.1 5.3 GO:0042169 SH2 domain binding(GO:0042169)
0.1 5.3 GO:0003777 microtubule motor activity(GO:0003777)
0.2 5.0 GO:0070064 proline-rich region binding(GO:0070064)