Motif ID: Lhx2_Hoxc5

Z-value: 0.540

Transcription factors associated with Lhx2_Hoxc5:

Gene SymbolEntrez IDGene Name
Hoxc5 ENSMUSG00000022485.3 Hoxc5
Lhx2 ENSMUSG00000000247.5 Lhx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx2mm10_v2_chr2_+_38341068_38341092-0.411.4e-03Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx2_Hoxc5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_105789869 2.035 ENSMUST00000184254.1
Gm12728
predicted gene 12728
chr1_+_24177610 2.009 ENSMUST00000054588.8
Col9a1
collagen, type IX, alpha 1
chr3_+_146121655 1.858 ENSMUST00000039450.4
Mcoln3
mucolipin 3
chr5_-_138170992 1.748 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr11_+_32283511 1.731 ENSMUST00000093209.3
Hba-a1
hemoglobin alpha, adult chain 1
chr4_+_3938888 1.672 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr8_-_106573461 1.641 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr2_+_109917639 1.574 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_-_168767136 1.504 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr2_-_155074447 1.499 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chrM_+_8600 1.449 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr2_-_168767029 1.401 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr10_-_77166545 1.345 ENSMUST00000081654.6
Col18a1
collagen, type XVIII, alpha 1
chr1_-_175979114 1.333 ENSMUST00000104983.1
B020018G12Rik
RIKEN cDNA B020018G12 gene
chr4_+_145510759 1.326 ENSMUST00000105742.1
ENSMUST00000136309.1
Gm13225

predicted gene 13225

chr17_+_20570362 1.183 ENSMUST00000095633.3
Gm5145
predicted pseudogene 5145
chr6_+_116650674 1.183 ENSMUST00000067354.5
ENSMUST00000178241.1
8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr12_-_87444017 1.167 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr15_+_84232030 1.166 ENSMUST00000023072.6
Parvb
parvin, beta
chr11_+_58171648 1.159 ENSMUST00000020820.1
Mrpl22
mitochondrial ribosomal protein L22

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 187 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0006412 translation(GO:0006412)
0.2 2.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 2.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 2.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 2.2 GO:0009060 aerobic respiration(GO:0009060)
0.1 2.0 GO:0003417 growth plate cartilage development(GO:0003417)
0.6 1.7 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.0 1.7 GO:0048821 erythrocyte development(GO:0048821)
0.5 1.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 1.6 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 1.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.2 1.5 GO:0019532 oxalate transport(GO:0019532)
0.2 1.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.1 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.1 GO:0006414 translational elongation(GO:0006414)
0.0 1.1 GO:0016574 histone ubiquitination(GO:0016574)
0.3 1.0 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 1.0 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 1.0 GO:0034063 stress granule assembly(GO:0034063)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 3.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 3.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 2.6 GO:0042555 MCM complex(GO:0042555)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)
0.5 2.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.2 2.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 1.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.7 GO:0070469 respiratory chain(GO:0070469)
0.0 1.3 GO:0000792 heterochromatin(GO:0000792)
0.1 1.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 1.1 GO:0031083 BLOC-1 complex(GO:0031083)
0.2 1.0 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 1.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 0.9 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.9 GO:0001739 sex chromatin(GO:0001739)
0.1 0.9 GO:0016272 prefoldin complex(GO:0016272)
0.2 0.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 2.6 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.1 2.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 2.0 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 2.0 GO:0000049 tRNA binding(GO:0000049)
0.4 1.7 GO:0031720 haptoglobin binding(GO:0031720)
0.1 1.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.3 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.3 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 1.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.0 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 0.9 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.9 GO:0051082 unfolded protein binding(GO:0051082)