Motif ID: Lhx3

Z-value: 0.698


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 74 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_136143497 8.884 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr7_-_45103747 6.295 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr3_+_122419772 5.977 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr13_+_49608030 5.170 ENSMUST00000021822.5
 Ogn
osteoglycin
chr7_-_103827922 4.856 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr14_-_48665098 4.606 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_84425258 4.137 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr5_-_70842617 3.098 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr11_+_59306920 2.959 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr11_+_109543694 2.765 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr5_-_62766153 2.738 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_-_56536895 2.601 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr17_-_67950908 2.564 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr19_+_20601958 2.421 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr10_+_75037291 2.225 ENSMUST00000139384.1
 Rab36
RAB36, member RAS oncogene family
chr4_+_102589687 2.213 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr5_-_62765618 2.117 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_75037066 2.032 ENSMUST00000147802.1
ENSMUST00000020391.5
 Rab36

RAB36, member RAS oncogene family

chr3_-_67515487 1.995 ENSMUST00000178314.1
ENSMUST00000054825.4
 Rarres1

retinoic acid receptor responder (tazarotene induced) 1

chr5_-_51553896 1.797 ENSMUST00000132734.1
 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.9 GO:0071398 cellular response to fatty acid(GO:0071398)
0.2 5.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 5.8 GO:0019882 antigen processing and presentation(GO:0019882)
1.2 4.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.0 4.1 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 3.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 3.0 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.2 2.8 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.9 2.6 GO:0021759 globus pallidus development(GO:0021759)
0.6 2.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.6 2.4 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 2.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.2 GO:0046677 response to antibiotic(GO:0046677)
0.6 1.8 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.2 1.6 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 1.5 GO:0019532 oxalate transport(GO:0019532)
0.4 1.1 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.2 0.9 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.3 0.8 GO:0035633 maintenance of blood-brain barrier(GO:0035633)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.9 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.2 4.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 4.2 GO:0030426 growth cone(GO:0030426)
0.2 3.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 2.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.2 GO:0016607 nuclear speck(GO:0016607)
0.0 1.8 GO:0097440 apical dendrite(GO:0097440)
0.1 1.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 0.9 GO:0042585 germinal vesicle(GO:0042585)
0.3 0.9 GO:0032437 cuticular plate(GO:0032437)
0.2 0.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 0.3 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 GO:0005504 fatty acid binding(GO:0005504)
2.1 6.3 GO:0019770 IgG receptor activity(GO:0019770)
0.0 6.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 5.2 GO:0008083 growth factor activity(GO:0008083)
1.2 4.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 4.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 4.7 GO:0005525 GTP binding(GO:0005525)
0.0 4.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.0 4.1 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.2 3.1 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.1 3.0 GO:0005109 frizzled binding(GO:0005109)
0.3 2.8 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0 2.8 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.2 2.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.4 2.4 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 2.2 GO:0030552 cAMP binding(GO:0030552)
0.1 1.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 1.6 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 1.1 GO:0045134 uridine-diphosphatase activity(GO:0045134)