Motif ID: Lhx3

Z-value: 0.698


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_136143497 8.884 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr7_-_45103747 6.295 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr3_+_122419772 5.977 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr13_+_49608030 5.170 ENSMUST00000021822.5
Ogn
osteoglycin
chr7_-_103827922 4.856 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr14_-_48665098 4.606 ENSMUST00000118578.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_84425258 4.137 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chr5_-_70842617 3.098 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr11_+_59306920 2.959 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr11_+_109543694 2.765 ENSMUST00000106696.1
Arsg
arylsulfatase G
chr5_-_62766153 2.738 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_-_56536895 2.601 ENSMUST00000001536.8
Nkx2-1
NK2 homeobox 1
chr17_-_67950908 2.564 ENSMUST00000164647.1
Arhgap28
Rho GTPase activating protein 28
chr19_+_20601958 2.421 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr10_+_75037291 2.225 ENSMUST00000139384.1
Rab36
RAB36, member RAS oncogene family
chr4_+_102589687 2.213 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr5_-_62765618 2.117 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_75037066 2.032 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr3_-_67515487 1.995 ENSMUST00000178314.1
ENSMUST00000054825.4
Rarres1

retinoic acid receptor responder (tazarotene induced) 1

chr5_-_51553896 1.797 ENSMUST00000132734.1
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chrX_-_139871637 1.730 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4

microrchidia 4

chr13_-_101692624 1.633 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr10_-_53647080 1.629 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr10_-_64090265 1.577 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_-_57294880 1.498 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr18_+_57468478 1.264 ENSMUST00000091892.2
Ctxn3
cortexin 3
chr3_+_66985680 1.253 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr3_+_151437887 1.246 ENSMUST00000046977.7
Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr10_-_64090241 1.189 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr14_+_69347587 1.090 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr4_-_14621805 1.041 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr3_+_66985647 0.989 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr3_-_116712644 0.950 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr8_-_21906412 0.943 ENSMUST00000051965.4
Defb11
defensin beta 11
chrX_+_66653003 0.937 ENSMUST00000036043.4
Slitrk2
SLIT and NTRK-like family, member 2
chr3_+_53845086 0.926 ENSMUST00000108014.1
Gm10985
predicted gene 10985
chr2_-_33087169 0.918 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr10_-_37138863 0.883 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chr11_-_30198232 0.878 ENSMUST00000102838.3
Sptbn1
spectrin beta, non-erythrocytic 1
chr2_-_33086366 0.831 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_36230426 0.805 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr6_+_34780412 0.796 ENSMUST00000115016.1
ENSMUST00000115017.1
Agbl3

ATP/GTP binding protein-like 3

chr3_+_84952146 0.713 ENSMUST00000029727.7
Fbxw7
F-box and WD-40 domain protein 7
chr11_-_89639631 0.693 ENSMUST00000128717.1
Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr17_-_78684262 0.674 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr10_-_62507737 0.673 ENSMUST00000020271.6
Srgn
serglycin
chr4_+_118961578 0.646 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr4_+_147492417 0.559 ENSMUST00000105721.2
Gm13152
predicted gene 13152
chrX_-_94123087 0.546 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chr10_-_33624587 0.454 ENSMUST00000160299.1
ENSMUST00000019920.6
Clvs2

clavesin 2

chr3_+_95318782 0.431 ENSMUST00000139866.1
Cers2
ceramide synthase 2
chr2_-_164171113 0.418 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr3_+_142620596 0.397 ENSMUST00000165774.1
Gbp2
guanylate binding protein 2
chr7_-_37772868 0.382 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr4_-_14621669 0.381 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr1_-_158356258 0.377 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr4_+_134930898 0.339 ENSMUST00000030622.2
Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr17_-_56036546 0.312 ENSMUST00000003268.9
Sh3gl1
SH3-domain GRB2-like 1
chr2_+_163658370 0.245 ENSMUST00000164399.1
ENSMUST00000064703.6
ENSMUST00000099105.2
ENSMUST00000152418.1
ENSMUST00000126182.1
ENSMUST00000131228.1
Pkig





protein kinase inhibitor, gamma





chr10_+_116143881 0.209 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr2_+_3114220 0.207 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chrX_+_166344692 0.195 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b





glycoprotein m6b





chr4_+_147132038 0.178 ENSMUST00000084149.3
Gm13139
predicted gene 13139
chr10_+_23797052 0.135 ENSMUST00000133289.1
Slc18b1
solute carrier family 18, subfamily B, member 1
chr4_-_14621494 0.109 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chrX_+_100625737 0.106 ENSMUST00000048962.3
Kif4
kinesin family member 4
chr13_-_74482943 0.067 ENSMUST00000074369.6
Zfp825
zinc finger protein 825
chr4_-_147809788 0.046 ENSMUST00000105734.3
ENSMUST00000176201.1
Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr1_-_36273425 0.045 ENSMUST00000056946.6
Neurl3
neuralized homolog 3 homolog (Drosophila)
chr9_+_96258697 0.035 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr19_+_46397009 0.030 ENSMUST00000118440.1
Sufu
suppressor of fused homolog (Drosophila)
chr17_+_45734506 0.026 ENSMUST00000180558.1
F630040K05Rik
RIKEN cDNA F630040K05 gene
chr3_+_41742615 0.018 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr4_+_145510759 0.000 ENSMUST00000105742.1
ENSMUST00000136309.1
Gm13225

predicted gene 13225


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.0 4.1 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.9 2.6 GO:0021759 globus pallidus development(GO:0021759)
0.6 2.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.6 2.4 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.6 1.8 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.4 1.1 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.3 8.9 GO:0071398 cellular response to fatty acid(GO:0071398)
0.3 0.8 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 0.7 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.2 1.5 GO:0019532 oxalate transport(GO:0019532)
0.2 0.9 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 2.8 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.2 0.7 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 2.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 5.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 1.6 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.4 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.1 0.8 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 3.0 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 3.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.7 GO:0050957 equilibrioception(GO:0050957)
0.1 2.2 GO:0046677 response to antibiotic(GO:0046677)
0.1 5.8 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 0.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.5 GO:0060746 parental behavior(GO:0060746)
0.0 0.4 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 0.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.4 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.1 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 0.9 GO:0042585 germinal vesicle(GO:0042585)
0.3 0.9 GO:0032437 cuticular plate(GO:0032437)
0.2 0.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 3.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 2.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.7 GO:0042629 mast cell granule(GO:0042629)
0.1 1.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 1.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.4 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 8.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 4.2 GO:0030426 growth cone(GO:0030426)
0.0 2.2 GO:0016607 nuclear speck(GO:0016607)
0.0 6.9 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0019770 IgG receptor activity(GO:0019770)
1.2 4.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
1.0 4.1 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.4 1.6 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.4 2.4 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 2.8 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.2 2.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 0.6 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.2 8.0 GO:0005504 fatty acid binding(GO:0005504)
0.2 3.1 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.2 1.1 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.7 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 1.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 4.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 3.0 GO:0005109 frizzled binding(GO:0005109)
0.1 2.2 GO:0030552 cAMP binding(GO:0030552)
0.0 5.2 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 2.8 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 6.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 4.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 4.7 GO:0005525 GTP binding(GO:0005525)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)