Motif ID: Lhx4

Z-value: 0.906


Transcription factors associated with Lhx4:

Gene SymbolEntrez IDGene Name
Lhx4 ENSMUSG00000026468.8 Lhx4



Activity profile for motif Lhx4.

activity profile for motif Lhx4


Sorted Z-values histogram for motif Lhx4

Sorted Z-values for motif Lhx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 16.802 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr7_-_49636847 11.607 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr19_+_44493472 10.660 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr4_+_136143497 8.689 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr3_+_122419772 7.842 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr11_+_59306920 7.127 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr9_+_72806874 6.514 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr1_-_163289214 6.284 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr7_-_37773555 5.713 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr2_-_166155272 5.443 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr4_+_65124174 5.409 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr17_-_48432723 5.400 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr5_-_62765618 5.088 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_+_34592248 4.970 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr9_+_119063429 4.774 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr2_-_166155624 4.758 ENSMUST00000109249.2
 Sulf2
sulfatase 2
chr16_-_22161450 4.643 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr15_-_103215285 4.642 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr2_-_28916412 4.451 ENSMUST00000050776.2
ENSMUST00000113849.1
 Barhl1

BarH-like 1 (Drosophila)

chr15_-_56694525 4.059 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 16.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.7 12.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.7 11.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 10.9 GO:0016055 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
0.8 10.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
2.6 10.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 10.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 8.0 GO:0071398 cellular response to fatty acid(GO:0071398)
0.1 7.8 GO:0007605 sensory perception of sound(GO:0007605)
0.3 7.1 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.8 6.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.6 6.3 GO:0048664 neuron fate determination(GO:0048664)
0.2 6.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.3 5.4 GO:0080111 DNA demethylation(GO:0080111)
0.1 5.4 GO:0051384 response to glucocorticoid(GO:0051384)
0.0 5.4 GO:0007067 mitotic nuclear division(GO:0007067)
0.2 4.8 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 4.8 GO:0051693 actin filament capping(GO:0051693)
0.0 4.2 GO:0051028 mRNA transport(GO:0051028)
1.0 4.1 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 10.5 GO:0030426 growth cone(GO:0030426)
0.3 10.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 10.3 GO:0005615 extracellular space(GO:0005615)
0.0 7.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.7 GO:0000776 kinetochore(GO:0000776)
0.2 4.6 GO:0010369 chromocenter(GO:0010369)
1.2 3.7 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 3.5 GO:0005884 actin filament(GO:0005884)
1.1 3.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 3.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 3.2 GO:0030139 endocytic vesicle(GO:0030139)
0.1 3.1 GO:0002102 podosome(GO:0002102)
0.0 3.1 GO:0005902 microvillus(GO:0005902)
0.0 3.0 GO:0016459 myosin complex(GO:0016459)
0.2 2.8 GO:0043205 fibril(GO:0043205)
0.3 2.7 GO:0032797 SMN complex(GO:0032797)
0.0 2.7 GO:0072372 primary cilium(GO:0072372)
0.5 2.5 GO:0031523 Myb complex(GO:0031523)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.8 GO:0005109 frizzled binding(GO:0005109)
0.1 17.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.8 11.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
2.0 10.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 9.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 8.7 GO:0071837 HMG box domain binding(GO:0071837)
0.2 8.6 GO:0005504 fatty acid binding(GO:0005504)
0.2 7.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 7.1 GO:0003779 actin binding(GO:0003779)
0.9 6.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 5.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.2 GO:0000287 magnesium ion binding(GO:0000287)
0.4 4.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 4.6 GO:0035064 methylated histone binding(GO:0035064)
1.4 4.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 3.9 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 3.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.7 3.7 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.3 3.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.4 3.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)