Motif ID: Lhx5_Lmx1b_Lhx1
Z-value: 0.447
Transcription factors associated with Lhx5_Lmx1b_Lhx1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Lhx1 | ENSMUSG00000018698.9 | Lhx1 |
Lhx5 | ENSMUSG00000029595.7 | Lhx5 |
Lmx1b | ENSMUSG00000038765.7 | Lmx1b |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Lmx1b | mm10_v2_chr2_-_33640480_33640511 | -0.11 | 4.0e-01 | Click! |
Lhx5 | mm10_v2_chr5_+_120431770_120431905 | -0.07 | 6.1e-01 | Click! |
Lhx1 | mm10_v2_chr11_-_84525514_84525542 | 0.05 | 7.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.0 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
0.5 | 1.5 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
0.3 | 1.4 | GO:0002024 | diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845) |
0.3 | 1.3 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375) |
0.3 | 1.0 | GO:0035063 | nuclear speck organization(GO:0035063) |
0.3 | 0.8 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
0.2 | 3.9 | GO:0021860 | pyramidal neuron development(GO:0021860) |
0.2 | 2.2 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
0.2 | 2.2 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.2 | 1.1 | GO:0019532 | oxalate transport(GO:0019532) |
0.2 | 0.5 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
0.1 | 0.7 | GO:1900170 | prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
0.1 | 0.7 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
0.1 | 0.4 | GO:0046110 | xanthine metabolic process(GO:0046110) |
0.1 | 0.3 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.1 | 0.4 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
0.1 | 0.6 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
0.1 | 0.6 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
0.1 | 0.4 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.1 | 0.3 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
0.1 | 0.2 | GO:1902605 | heterotrimeric G-protein complex assembly(GO:1902605) |
0.1 | 0.7 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
0.1 | 0.3 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
0.1 | 0.9 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
0.1 | 0.3 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
0.1 | 0.2 | GO:0042420 | dopamine catabolic process(GO:0042420) |
0.0 | 0.6 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
0.0 | 0.7 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
0.0 | 0.4 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
0.0 | 0.2 | GO:0033762 | response to glucagon(GO:0033762) |
0.0 | 0.1 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.0 | 0.6 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
0.0 | 0.1 | GO:0060489 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
0.0 | 0.3 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.0 | 0.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.0 | 0.4 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
0.0 | 0.1 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
0.0 | 1.7 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
0.0 | 0.9 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 0.2 | GO:0060046 | regulation of acrosome reaction(GO:0060046) |
0.0 | 0.3 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
0.0 | 0.3 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) negative regulation of histone H3-K9 trimethylation(GO:1900113) |
0.0 | 0.2 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
0.0 | 0.3 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
0.0 | 0.4 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
0.0 | 0.1 | GO:0090240 | positive regulation of histone H4 acetylation(GO:0090240) |
0.0 | 0.1 | GO:0036337 | Fas signaling pathway(GO:0036337) |
0.0 | 0.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.0 | 0.1 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
0.0 | 0.1 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
0.0 | 0.1 | GO:0090239 | regulation of histone H4 acetylation(GO:0090239) |
0.0 | 0.5 | GO:0008053 | mitochondrial fusion(GO:0008053) |
0.0 | 0.1 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
0.0 | 0.2 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
0.0 | 0.8 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.0 | 0.5 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
0.0 | 0.7 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
0.0 | 0.1 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
0.0 | 0.0 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
0.0 | 0.2 | GO:0070995 | NADPH oxidation(GO:0070995) |
0.0 | 0.1 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) |
0.0 | 0.1 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
0.0 | 0.2 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
0.0 | 0.2 | GO:0071624 | positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023) |
0.0 | 0.1 | GO:0046208 | spermine catabolic process(GO:0046208) |
0.0 | 0.5 | GO:0030901 | midbrain development(GO:0030901) |
0.0 | 0.0 | GO:0090296 | regulation of mitochondrial DNA replication(GO:0090296) negative regulation of mitochondrial DNA replication(GO:0090298) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.6 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.2 | 0.5 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.1 | 1.7 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.1 | 0.4 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.1 | 0.8 | GO:0042581 | specific granule(GO:0042581) |
0.1 | 0.6 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.1 | 0.2 | GO:0036156 | inner dynein arm(GO:0036156) |
0.1 | 0.7 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
0.0 | 0.3 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.3 | GO:0071439 | clathrin complex(GO:0071439) |
0.0 | 0.1 | GO:0060187 | cell pole(GO:0060187) |
0.0 | 0.2 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.0 | 0.4 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.0 | 0.4 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
0.0 | 0.4 | GO:0000346 | transcription export complex(GO:0000346) |
0.0 | 0.5 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
0.0 | 0.3 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
0.0 | 0.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.3 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.3 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
0.0 | 0.1 | GO:0042612 | MHC class I protein complex(GO:0042612) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.4 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
0.2 | 0.7 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
0.2 | 4.1 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.2 | 0.5 | GO:0004556 | alpha-amylase activity(GO:0004556) |
0.1 | 1.3 | GO:0038191 | neuropilin binding(GO:0038191) |
0.1 | 0.9 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
0.1 | 1.1 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.1 | 0.3 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) |
0.1 | 1.9 | GO:0030275 | LRR domain binding(GO:0030275) |
0.1 | 0.4 | GO:0030151 | molybdenum ion binding(GO:0030151) |
0.1 | 0.6 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.1 | 0.3 | GO:0036033 | mediator complex binding(GO:0036033) |
0.1 | 0.4 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.1 | 0.5 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
0.1 | 0.3 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
0.1 | 0.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 2.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.0 | 0.1 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
0.0 | 0.6 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.0 | 0.2 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
0.0 | 0.2 | GO:0051378 | primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378) |
0.0 | 0.2 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
0.0 | 0.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.0 | 0.4 | GO:0035312 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) 5'-3' exodeoxyribonuclease activity(GO:0035312) |
0.0 | 2.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
0.0 | 0.4 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.0 | 0.2 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
0.0 | 0.2 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.9 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 0.1 | GO:0032184 | SUMO polymer binding(GO:0032184) |
0.0 | 0.1 | GO:0045503 | dynein light chain binding(GO:0045503) |
0.0 | 0.1 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
0.0 | 0.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.0 | 0.2 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
0.0 | 0.1 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
0.0 | 0.8 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 0.1 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.0 | 0.3 | GO:0031489 | myosin V binding(GO:0031489) |
0.0 | 0.0 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.0 | 0.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
0.0 | 0.1 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.0 | 0.2 | GO:0035380 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677) |
0.0 | 0.5 | GO:0004120 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715) |
0.0 | 0.2 | GO:0070402 | NADPH binding(GO:0070402) |
0.0 | 0.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |