Motif ID: Lhx5_Lmx1b_Lhx1

Z-value: 0.447

Transcription factors associated with Lhx5_Lmx1b_Lhx1:

Gene SymbolEntrez IDGene Name
Lhx1 ENSMUSG00000018698.9 Lhx1
Lhx5 ENSMUSG00000029595.7 Lhx5
Lmx1b ENSMUSG00000038765.7 Lmx1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lmx1bmm10_v2_chr2_-_33640480_33640511-0.114.0e-01Click!
Lhx5mm10_v2_chr5_+_120431770_120431905-0.076.1e-01Click!
Lhx1mm10_v2_chr11_-_84525514_845255420.057.2e-01Click!


Activity profile for motif Lhx5_Lmx1b_Lhx1.

activity profile for motif Lhx5_Lmx1b_Lhx1


Sorted Z-values histogram for motif Lhx5_Lmx1b_Lhx1

Sorted Z-values for motif Lhx5_Lmx1b_Lhx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_87359011 2.244 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr15_-_93595877 2.025 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chrX_-_143933204 2.018 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 1.903 ENSMUST00000087313.3
 Dcx
doublecortin
chr1_-_158356258 1.678 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr18_-_66860458 1.356 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr5_+_13398688 1.347 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr4_+_102589687 1.308 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr7_+_66365905 1.163 ENSMUST00000107486.1
 Gm10974
predicted gene 10974
chr5_-_118244861 1.124 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr13_+_77135513 1.114 ENSMUST00000168779.1
 2210408I21Rik
RIKEN cDNA 2210408I21 gene
chr6_+_8948608 1.042 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr1_+_72284367 1.033 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr13_+_67833235 1.028 ENSMUST00000060609.7
 Gm10037
predicted gene 10037
chr16_+_11406618 1.028 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr19_-_5802640 1.027 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr4_-_14621805 0.908 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr2_+_68104671 0.886 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr8_+_34054622 0.877 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr8_-_67910911 0.865 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.2 2.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 2.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.7 2.0 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.0 1.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.5 1.5 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.3 1.4 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.3 1.3 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.2 1.1 GO:0019532 oxalate transport(GO:0019532)
0.3 1.0 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.9 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 0.8 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0 0.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.7 GO:1900170 prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 0.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.7 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.7 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.6 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.8 GO:0042581 specific granule(GO:0042581)
0.1 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 0.6 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.4 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 0.3 GO:0090543 Flemming body(GO:0090543)
0.0 0.3 GO:0071439 clathrin complex(GO:0071439)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.2 GO:0045275 respiratory chain complex III(GO:0045275)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 2.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 2.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.9 GO:0030275 LRR domain binding(GO:0030275)
0.5 1.4 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 1.3 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.9 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0045296 cadherin binding(GO:0045296)
0.2 0.7 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 0.5 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.5 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.1 0.4 GO:0030151 molybdenum ion binding(GO:0030151)