Motif ID: Lhx8

Z-value: 0.629


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.038.5e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_66851513 4.184 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr5_+_137553517 2.751 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr8_+_34054622 2.708 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr7_+_91090697 2.685 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 2.676 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr2_+_65620829 2.623 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr8_+_104831572 2.604 ENSMUST00000059449.6
 Ces2b
carboxyesterase 2B
chr3_-_73056943 2.413 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr2_-_52558539 2.411 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr15_+_21111452 2.369 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr13_-_66852017 2.324 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr6_-_136173492 2.290 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr13_-_62466709 2.244 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chr5_-_139129662 2.239 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr1_+_72284367 1.899 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr1_-_44218952 1.832 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E
chr18_+_23415400 1.805 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr13_+_62129894 1.742 ENSMUST00000099449.3
 Zfp808
zinc finger protein 80
chrX_+_101640056 1.621 ENSMUST00000119299.1
ENSMUST00000044475.4
 Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr2_-_67433181 1.600 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.4 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.7 2.6 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.3 2.4 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 2.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.3 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.2 2.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.5 1.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.3 1.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3 1.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 1.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 1.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 1.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 1.0 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.9 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.9 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.9 GO:0007601 visual perception(GO:0007601)
0.3 0.8 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.8 GO:0016514 SWI/SNF complex(GO:0016514)
0.2 2.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 2.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 2.3 GO:0043083 synaptic cleft(GO:0043083)
0.2 2.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 1.6 GO:0070688 MLL5-L complex(GO:0070688)
0.0 1.5 GO:0042734 presynaptic membrane(GO:0042734)
0.3 1.1 GO:0031673 H zone(GO:0031673)
0.0 1.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.9 GO:0005922 connexon complex(GO:0005922)
0.0 0.9 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.8 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.2 0.6 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.4 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 2.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 2.6 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.2 2.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.4 GO:0030165 PDZ domain binding(GO:0030165)
0.2 2.3 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.2 2.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 1.8 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.5 1.6 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.4 1.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.1 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.1 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.6 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)