Motif ID: Mafa

Z-value: 1.460


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_757479220.104.7e-01Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_98033181 21.562 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr9_-_98032983 20.987 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr7_+_54835959 17.581 ENSMUST00000082373.6
 Luzp2
leucine zipper protein 2
chr16_-_17576631 17.250 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
 Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr10_+_58813359 15.681 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr14_+_119138415 14.068 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chrX_-_73869804 14.037 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr16_-_74411292 13.252 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr16_+_96467606 12.259 ENSMUST00000061739.8
 Pcp4
Purkinje cell protein 4
chr1_-_136260873 11.928 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr16_-_74411776 11.852 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr12_+_3365108 11.845 ENSMUST00000020999.5
 Kif3c
kinesin family member 3C
chr1_-_169747634 11.283 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr4_+_102254993 11.159 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr8_-_70487314 10.524 ENSMUST00000045286.7
 Tmem59l
transmembrane protein 59-like
chr10_-_84440591 10.141 ENSMUST00000020220.8
 Nuak1
NUAK family, SNF1-like kinase, 1
chr16_+_91269759 9.564 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr5_+_111417263 9.446 ENSMUST00000094463.4
 Mn1
meningioma 1
chr12_-_86884808 8.951 ENSMUST00000038422.6
 Irf2bpl
interferon regulatory factor 2 binding protein-like
chr4_+_43406435 8.904 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr11_-_66525795 8.434 ENSMUST00000123454.1
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr1_-_38836090 7.763 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr12_+_105453831 7.610 ENSMUST00000178224.1
 D430019H16Rik
RIKEN cDNA D430019H16 gene
chr15_-_25413752 7.254 ENSMUST00000058845.7
 Basp1
brain abundant, membrane attached signal protein 1
chr4_+_102254739 6.596 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr14_+_64588112 6.502 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr17_-_72603709 5.763 ENSMUST00000086639.4
 Alk
anaplastic lymphoma kinase
chr11_-_66525964 5.678 ENSMUST00000066679.6
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr8_-_84937347 5.430 ENSMUST00000109741.2
ENSMUST00000119820.1
 Mast1

microtubule associated serine/threonine kinase 1

chr5_-_142509653 4.816 ENSMUST00000110784.1
 Radil
Ras association and DIL domains
chr1_-_121328024 4.587 ENSMUST00000003818.7
 Insig2
insulin induced gene 2
chr8_+_93810832 4.323 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr5_-_124187150 4.251 ENSMUST00000161938.1
 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chrX_-_20950597 4.094 ENSMUST00000009550.7
 Elk1
ELK1, member of ETS oncogene family
chr9_+_108002501 4.077 ENSMUST00000035214.4
ENSMUST00000175874.1
 Ip6k1

inositol hexaphosphate kinase 1

chr19_+_27217357 3.403 ENSMUST00000047645.6
ENSMUST00000167487.1
 Vldlr

very low density lipoprotein receptor

chr4_+_59003121 3.400 ENSMUST00000095070.3
ENSMUST00000174664.1
 Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chrX_+_152178945 3.319 ENSMUST00000096275.4
 Iqsec2
IQ motif and Sec7 domain 2
chr12_-_75177325 3.189 ENSMUST00000042299.2
 Kcnh5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr9_-_105131775 3.141 ENSMUST00000035179.6
 Nudt16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr1_-_105356658 3.021 ENSMUST00000058688.5
ENSMUST00000172299.1
 Rnf152

ring finger protein 152

chr1_-_121327734 3.004 ENSMUST00000160968.1
ENSMUST00000162582.1
 Insig2

insulin induced gene 2

chr1_-_121327672 2.962 ENSMUST00000159085.1
ENSMUST00000159125.1
ENSMUST00000161818.1
 Insig2


insulin induced gene 2


chr11_-_107337556 2.945 ENSMUST00000040380.6
 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr1_-_121327776 2.881 ENSMUST00000160688.1
 Insig2
insulin induced gene 2
chr4_+_21931291 2.808 ENSMUST00000029908.7
 Faxc
failed axon connections homolog (Drosophila)
chr19_+_27217011 2.745 ENSMUST00000164746.1
ENSMUST00000172302.1
 Vldlr

very low density lipoprotein receptor

chr7_+_140856957 2.646 ENSMUST00000026558.6
 Ric8
resistance to inhibitors of cholinesterase 8 homolog (C. elegans)
chr8_+_60993189 2.631 ENSMUST00000034065.7
ENSMUST00000120689.1
 Nek1

NIMA (never in mitosis gene a)-related expressed kinase 1

chr8_-_105565985 2.442 ENSMUST00000013304.7
 Atp6v0d1
ATPase, H+ transporting, lysosomal V0 subunit D1
chr7_-_12684991 2.321 ENSMUST00000172743.1
ENSMUST00000167771.1
 Vmn2r55

vomeronasal 2, receptor 55

chr13_+_4233730 2.191 ENSMUST00000081326.6
 Akr1c19
aldo-keto reductase family 1, member C19
chr11_+_87595646 1.954 ENSMUST00000134216.1
 Mtmr4
myotubularin related protein 4
chr5_-_24423516 1.924 ENSMUST00000030814.6
 Cdk5
cyclin-dependent kinase 5
chr7_-_67759735 1.846 ENSMUST00000074233.4
ENSMUST00000051389.8
 Synm

synemin, intermediate filament protein

chrX_-_122397351 1.825 ENSMUST00000079490.4
 Nap1l3
nucleosome assembly protein 1-like 3
chrX_+_104482774 1.711 ENSMUST00000087867.5
 Uprt
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr6_+_85187438 1.708 ENSMUST00000045942.8
 Emx1
empty spiracles homeobox 1
chr11_-_119228461 1.597 ENSMUST00000036113.3
 Tbc1d16
TBC1 domain family, member 16
chr6_-_35308110 1.573 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr17_-_47010513 1.559 ENSMUST00000113337.2
ENSMUST00000113335.2
 Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chr9_-_51077064 1.457 ENSMUST00000098782.3
 Layn
layilin
chr5_+_24423805 1.418 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr9_-_109059216 1.392 ENSMUST00000112053.1
 Trex1
three prime repair exonuclease 1
chr9_-_109059711 1.120 ENSMUST00000061973.4
 Trex1
three prime repair exonuclease 1
chr4_+_155601414 1.110 ENSMUST00000105608.2
 Slc35e2
solute carrier family 35, member E2
chr7_-_139616309 1.091 ENSMUST00000166503.1
ENSMUST00000093991.3
 E030019B06Rik

RIKEN cDNA E030019B06 gene

chr4_-_59138983 1.079 ENSMUST00000107547.1
 AI481877
expressed sequence AI481877
chr17_-_28080595 0.973 ENSMUST00000141806.1
ENSMUST00000043925.8
ENSMUST00000129046.1
 Tcp11


t-complex protein 11


chr17_-_28080567 0.845 ENSMUST00000114836.1
ENSMUST00000042692.5
 Tcp11

t-complex protein 11

chr7_-_18616498 0.729 ENSMUST00000057810.6
 Psg23
pregnancy-specific glycoprotein 23
chr9_-_45906837 0.709 ENSMUST00000161203.1
ENSMUST00000058720.5
ENSMUST00000160699.1
 Rnf214


ring finger protein 214


chr18_-_36197343 0.634 ENSMUST00000115713.1
ENSMUST00000115712.1
 Nrg2

neuregulin 2

chr4_+_155601854 0.553 ENSMUST00000118607.1
 Slc35e2
solute carrier family 35, member E2
chr17_+_47611570 0.550 ENSMUST00000024778.2
 Med20
mediator complex subunit 20
chr1_+_171213969 0.527 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
 Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr6_-_54566484 0.523 ENSMUST00000019268.4
 Scrn1
secernin 1
chr17_-_46752170 0.370 ENSMUST00000121671.1
ENSMUST00000059844.6
 Cnpy3

canopy 3 homolog (zebrafish)

chrX_-_95444789 0.348 ENSMUST00000084535.5
 Amer1
APC membrane recruitment 1
chr5_+_124629050 0.147 ENSMUST00000037865.8
 Atp6v0a2
ATPase, H+ transporting, lysosomal V0 subunit A2
chrX_-_97377190 0.101 ENSMUST00000037353.3
 Eda2r
ectodysplasin A2 receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 25.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
2.3 14.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.4 14.0 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
1.4 17.8 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
1.3 9.4 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
1.2 6.1 GO:0034436 glycoprotein transport(GO:0034436)
1.2 12.3 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
1.1 10.1 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.8 13.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.8 9.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.8 3.1 GO:0046709 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.8 14.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.6 42.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 1.7 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.5 3.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.5 1.6 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.5 17.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.5 1.6 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.5 7.3 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.4 4.1 GO:0006020 inositol metabolic process(GO:0006020)
0.4 1.9 GO:0033136 serine phosphorylation of STAT3 protein(GO:0033136) serine phosphorylation of STAT protein(GO:0042501)
0.3 3.0 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.2 3.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.1 11.8 GO:0072384 organelle transport along microtubule(GO:0072384)
0.1 1.7 GO:0060019 radial glial cell differentiation(GO:0060019)
0.1 2.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 7.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 4.1 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 4.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 9.6 GO:0048663 neuron fate commitment(GO:0048663)
0.1 0.3 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 2.5 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 2.6 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 1.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 4.8 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 5.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 1.6 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 10.6 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 1.4 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 1.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.9 GO:0006869 lipid transport(GO:0006869)
0.0 0.6 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
1.4 12.3 GO:0005883 neurofilament(GO:0005883)
1.0 11.8 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.8 17.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.8 25.1 GO:0030673 axolemma(GO:0030673)
0.6 1.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.5 6.1 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.3 14.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 13.7 GO:0044295 axonal growth cone(GO:0044295)
0.2 2.6 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 1.8 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.2 7.3 GO:0008180 COP9 signalosome(GO:0008180)
0.2 42.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.6 GO:0000242 pericentriolar material(GO:0000242)
0.1 4.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.1 GO:0043679 axon terminus(GO:0043679)
0.0 20.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.6 GO:0005769 early endosome(GO:0005769)
0.0 9.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 4.8 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 14.0 GO:0033691 sialic acid binding(GO:0033691)
2.8 25.1 GO:0008046 axon guidance receptor activity(GO:0008046)
2.0 6.1 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
1.0 4.1 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.7 4.3 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.6 1.9 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.6 2.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.5 3.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.4 14.1 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.4 17.8 GO:0030552 cAMP binding(GO:0030552)
0.3 1.7 GO:0004849 uridine kinase activity(GO:0004849)
0.3 2.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.3 3.1 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.3 11.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 1.6 GO:0070728 leucine binding(GO:0070728)
0.2 17.2 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.2 0.6 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 2.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 11.5 GO:0019894 kinesin binding(GO:0019894)
0.1 1.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 1.8 GO:0019215 intermediate filament binding(GO:0019215)
0.1 10.1 GO:0002039 p53 binding(GO:0002039)
0.1 3.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 5.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.4 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.1 10.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 23.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 6.8 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 13.4 GO:0008134 transcription factor binding(GO:0008134)
0.0 4.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 5.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.0 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 3.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 19.4 GO:0008270 zinc ion binding(GO:0008270)
0.0 4.6 GO:0005543 phospholipid binding(GO:0005543)
0.0 2.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)