Motif ID: Mafa

Z-value: 1.460


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_757479220.104.7e-01Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_98033181 21.562 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr9_-_98032983 20.987 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr7_+_54835959 17.581 ENSMUST00000082373.6
 Luzp2
leucine zipper protein 2
chr16_-_17576631 17.250 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
 Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr10_+_58813359 15.681 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr14_+_119138415 14.068 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chrX_-_73869804 14.037 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr16_-_74411292 13.252 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr16_+_96467606 12.259 ENSMUST00000061739.8
 Pcp4
Purkinje cell protein 4
chr1_-_136260873 11.928 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr16_-_74411776 11.852 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr12_+_3365108 11.845 ENSMUST00000020999.5
 Kif3c
kinesin family member 3C
chr1_-_169747634 11.283 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr4_+_102254993 11.159 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr8_-_70487314 10.524 ENSMUST00000045286.7
 Tmem59l
transmembrane protein 59-like
chr10_-_84440591 10.141 ENSMUST00000020220.8
 Nuak1
NUAK family, SNF1-like kinase, 1
chr16_+_91269759 9.564 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr5_+_111417263 9.446 ENSMUST00000094463.4
 Mn1
meningioma 1
chr12_-_86884808 8.951 ENSMUST00000038422.6
 Irf2bpl
interferon regulatory factor 2 binding protein-like
chr4_+_43406435 8.904 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 42.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
8.4 25.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.4 17.8 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 17.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
2.3 14.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.8 14.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.4 14.0 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.8 13.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
1.2 12.3 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.1 11.8 GO:0072384 organelle transport along microtubule(GO:0072384)
0.0 10.6 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
1.1 10.1 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 9.6 GO:0048663 neuron fate commitment(GO:0048663)
1.3 9.4 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.8 9.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.5 7.3 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 7.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
1.2 6.1 GO:0034436 glycoprotein transport(GO:0034436)
0.0 5.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 4.8 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 42.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.8 25.1 GO:0030673 axolemma(GO:0030673)
0.0 20.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.8 17.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 14.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 13.7 GO:0044295 axonal growth cone(GO:0044295)
1.7 13.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
1.4 12.3 GO:0005883 neurofilament(GO:0005883)
1.0 11.8 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 9.6 GO:0005667 transcription factor complex(GO:0005667)
0.2 7.3 GO:0008180 COP9 signalosome(GO:0008180)
0.5 6.1 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 4.8 GO:0005874 microtubule(GO:0005874)
0.1 4.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.1 GO:0043679 axon terminus(GO:0043679)
0.2 2.6 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 2.6 GO:0000242 pericentriolar material(GO:0000242)
0.6 1.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.2 1.8 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 1.6 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 25.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 23.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 19.4 GO:0008270 zinc ion binding(GO:0008270)
0.4 17.8 GO:0030552 cAMP binding(GO:0030552)
0.2 17.2 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.4 14.1 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
2.8 14.0 GO:0033691 sialic acid binding(GO:0033691)
0.0 13.4 GO:0008134 transcription factor binding(GO:0008134)
0.2 11.5 GO:0019894 kinesin binding(GO:0019894)
0.3 11.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 10.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 10.1 GO:0002039 p53 binding(GO:0002039)
0.0 6.8 GO:0005516 calmodulin binding(GO:0005516)
2.0 6.1 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.1 5.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 5.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 4.6 GO:0005543 phospholipid binding(GO:0005543)
0.7 4.3 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.0 4.1 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 4.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)