Motif ID: Maff

Z-value: 0.507


Transcription factors associated with Maff:

Gene SymbolEntrez IDGene Name
Maff ENSMUSG00000042622.7 Maff

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maffmm10_v2_chr15_+_79347534_793475560.411.3e-03Click!


Activity profile for motif Maff.

activity profile for motif Maff


Sorted Z-values histogram for motif Maff

Sorted Z-values for motif Maff



Network of associatons between targets according to the STRING database.



First level regulatory network of Maff

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_3270767 5.138 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr4_-_136886187 3.989 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr14_+_118787894 3.903 ENSMUST00000047761.6
ENSMUST00000071546.7
 Cldn10

claudin 10

chr7_-_110862944 3.332 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr13_-_23710714 3.044 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr6_+_120773633 2.700 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr17_-_25570678 2.597 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr16_-_22439719 2.216 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr5_+_104435112 2.132 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr1_-_120074023 1.615 ENSMUST00000056089.7
 Tmem37
transmembrane protein 37
chr11_+_82101836 1.493 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr4_+_102421518 1.484 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr19_+_56722372 1.425 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr3_-_59262825 1.149 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr5_+_140505550 1.098 ENSMUST00000043050.8
ENSMUST00000124142.1
 Chst12

carbohydrate sulfotransferase 12

chr12_+_35047180 1.068 ENSMUST00000048519.9
ENSMUST00000163677.1
 Snx13

sorting nexin 13

chr7_+_84528964 1.043 ENSMUST00000180387.1
 Gm2115
predicted gene 2115
chr11_-_109473598 1.042 ENSMUST00000070152.5
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr18_+_4921662 0.938 ENSMUST00000143254.1
 Svil
supervillin
chr7_-_100964371 0.929 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr13_+_66932802 0.913 ENSMUST00000021990.3
 Ptdss1
phosphatidylserine synthase 1
chr17_+_86963279 0.878 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr4_-_143299463 0.832 ENSMUST00000119654.1
 Pdpn
podoplanin
chr19_+_8929628 0.828 ENSMUST00000096241.4
 Eml3
echinoderm microtubule associated protein like 3
chr1_+_136017967 0.812 ENSMUST00000063719.8
ENSMUST00000118832.1
 Tmem9

transmembrane protein 9

chr1_+_136018062 0.799 ENSMUST00000117950.1
 Tmem9
transmembrane protein 9
chr1_-_136260873 0.782 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr4_-_143299498 0.726 ENSMUST00000030317.7
 Pdpn
podoplanin
chr19_-_8929323 0.724 ENSMUST00000096242.3
 Rom1
rod outer segment membrane protein 1
chr3_+_65109343 0.715 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr17_-_67950908 0.630 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr2_-_130397525 0.624 ENSMUST00000028897.7
 Cpxm1
carboxypeptidase X 1 (M14 family)
chr2_+_121866918 0.613 ENSMUST00000078752.3
ENSMUST00000110586.3
 Casc4

cancer susceptibility candidate 4

chr16_+_72663143 0.607 ENSMUST00000023600.7
 Robo1
roundabout homolog 1 (Drosophila)
chr2_+_121867083 0.594 ENSMUST00000089912.5
ENSMUST00000089915.3
 Casc4

cancer susceptibility candidate 4

chr7_-_64925560 0.562 ENSMUST00000149851.1
 Fam189a1
family with sequence similarity 189, member A1
chr6_+_30401866 0.545 ENSMUST00000068240.6
ENSMUST00000068259.6
 Klhdc10

kelch domain containing 10

chr5_-_67815852 0.525 ENSMUST00000141443.1
 Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr15_-_33687840 0.520 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chr1_+_127306706 0.491 ENSMUST00000171405.1
 Mgat5
mannoside acetylglucosaminyltransferase 5
chr10_+_62920648 0.490 ENSMUST00000144459.1
 Slc25a16
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
chr2_-_20943413 0.489 ENSMUST00000140230.1
 Arhgap21
Rho GTPase activating protein 21
chr11_-_116086929 0.479 ENSMUST00000074628.6
ENSMUST00000106444.3
 Wbp2

WW domain binding protein 2

chr8_+_25532125 0.447 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1
chr10_+_62920630 0.439 ENSMUST00000044977.3
 Slc25a16
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
chr3_+_109573907 0.423 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr19_+_26753588 0.388 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr14_+_20929416 0.382 ENSMUST00000022369.7
 Vcl
vinculin
chr19_-_57197556 0.350 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr1_+_75382114 0.316 ENSMUST00000113590.1
ENSMUST00000148515.1
 Speg

SPEG complex locus

chr3_-_108044801 0.315 ENSMUST00000178808.1
ENSMUST00000106670.1
ENSMUST00000029489.8
 Gstm4


glutathione S-transferase, mu 4


chr10_-_88605017 0.281 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr4_+_139352587 0.270 ENSMUST00000147999.1
ENSMUST00000042096.7
ENSMUST00000179784.1
ENSMUST00000082262.7
 Ubr4
Emc1


ubiquitin protein ligase E3 component n-recognin 4
ER membrane protein complex subunit 1


chr9_+_45838572 0.268 ENSMUST00000078111.4
ENSMUST00000034591.4
 Bace1

beta-site APP cleaving enzyme 1

chr5_+_103754560 0.234 ENSMUST00000153165.1
ENSMUST00000031256.5
 Aff1

AF4/FMR2 family, member 1

chr13_-_54749627 0.231 ENSMUST00000099506.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr7_+_16944645 0.178 ENSMUST00000094807.5
 Pnmal2
PNMA-like 2
chr6_+_83795022 0.169 ENSMUST00000113851.1
 Nagk
N-acetylglucosamine kinase
chr14_-_37135126 0.163 ENSMUST00000042564.9
 Ghitm
growth hormone inducible transmembrane protein
chr4_+_141239499 0.147 ENSMUST00000141834.2
 Arhgef19
Rho guanine nucleotide exchange factor (GEF) 19
chr13_-_54749849 0.146 ENSMUST00000135343.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr5_+_8056527 0.133 ENSMUST00000148633.1
 Sri
sorcin
chr3_+_96161981 0.132 ENSMUST00000054356.9
 Mtmr11
myotubularin related protein 11
chr15_-_78572754 0.106 ENSMUST00000043214.6
 Rac2
RAS-related C3 botulinum substrate 2
chr9_+_65214690 0.093 ENSMUST00000069000.7
 Parp16
poly (ADP-ribose) polymerase family, member 16
chr6_+_83794974 0.078 ENSMUST00000037376.7
 Nagk
N-acetylglucosamine kinase
chr5_-_102069905 0.078 ENSMUST00000053177.7
ENSMUST00000174698.1
 Wdfy3

WD repeat and FYVE domain containing 3

chr14_-_37135310 0.075 ENSMUST00000165649.2
 Ghitm
growth hormone inducible transmembrane protein
chr11_+_75651504 0.056 ENSMUST00000069057.6
 Myo1c
myosin IC
chr15_+_41789495 0.028 ENSMUST00000090095.5
ENSMUST00000022918.7
 Oxr1

oxidation resistance 1

chr10_-_121626316 0.024 ENSMUST00000039810.7
 Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr3_+_127791374 0.020 ENSMUST00000171621.1
 Tifa
TRAF-interacting protein with forkhead-associated domain
chr4_-_25281801 0.002 ENSMUST00000102994.3
 Ufl1
UFM1 specific ligase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
0.9 2.6 GO:0072034 renal vesicle induction(GO:0072034)
0.7 5.1 GO:0001887 selenium compound metabolic process(GO:0001887)
0.5 1.5 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.5 1.4 GO:1900133 renin secretion into blood stream(GO:0002001) negative regulation of urine volume(GO:0035811) regulation of renin secretion into blood stream(GO:1900133)
0.4 2.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 3.3 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.4 1.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 1.1 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.3 0.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.2 2.1 GO:0033280 response to vitamin D(GO:0033280)
0.2 4.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 0.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 0.9 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.2 0.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 1.6 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 0.4 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.1 1.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.5 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.1 0.5 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.7 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.7 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.9 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 0.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.3 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.0 0.1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.4 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.2 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.4 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:1990357 terminal web(GO:1990357)
0.1 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 4.0 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 1.3 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 3.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 2.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 4.6 GO:0045177 apical part of cell(GO:0045177)
0.0 1.9 GO:0005770 late endosome(GO:0005770)
0.0 1.8 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0051379 epinephrine binding(GO:0051379)
0.4 1.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.3 5.1 GO:0008430 selenium binding(GO:0008430)
0.3 3.0 GO:0039706 co-receptor binding(GO:0039706)
0.3 2.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 1.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.2 3.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.6 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.1 0.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.2 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.1 0.9 GO:0005522 profilin binding(GO:0005522)
0.1 0.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 2.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.7 GO:0070402 NADPH binding(GO:0070402)
0.0 1.5 GO:0030552 cAMP binding(GO:0030552)
0.0 3.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.7 GO:0015293 symporter activity(GO:0015293)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.6 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)