Motif ID: Max_Mycn

Z-value: 3.148

Transcription factors associated with Max_Mycn:

Gene SymbolEntrez IDGene Name
Max ENSMUSG00000059436.6 Max
Mycn ENSMUSG00000037169.8 Mycn

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maxmm10_v2_chr12_-_76962178_76962248-0.604.8e-07Click!
Mycnmm10_v2_chr12_-_12941827_12941914-0.246.7e-02Click!


Activity profile for motif Max_Mycn.

activity profile for motif Max_Mycn


Sorted Z-values histogram for motif Max_Mycn

Sorted Z-values for motif Max_Mycn



Network of associatons between targets according to the STRING database.



First level regulatory network of Max_Mycn

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103843154 38.485 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chrX_-_141725181 32.036 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr10_+_127063599 28.517 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr9_-_119578981 28.411 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr7_+_144896523 26.905 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr12_+_17544873 25.408 ENSMUST00000171737.1
 Odc1
ornithine decarboxylase, structural 1
chr5_-_76951560 24.960 ENSMUST00000140076.1
 Ppat
phosphoribosyl pyrophosphate amidotransferase
chr3_+_104638658 24.665 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr10_+_127063527 24.511 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr10_-_77113676 24.360 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr11_-_96005872 22.701 ENSMUST00000013559.2
 Igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
chr17_-_24960620 22.425 ENSMUST00000024981.7
 Hn1l
hematological and neurological expressed 1-like
chr9_+_21368014 22.296 ENSMUST00000067646.4
ENSMUST00000115414.1
 Ilf3

interleukin enhancer binding factor 3

chrX_-_134541847 21.645 ENSMUST00000054213.4
 Timm8a1
translocase of inner mitochondrial membrane 8A1
chr8_+_48109949 21.455 ENSMUST00000170263.2
ENSMUST00000033966.6
 Dctd

dCMP deaminase

chr11_-_12026732 21.255 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr11_-_69921190 20.867 ENSMUST00000108607.1
 Eif5a
eukaryotic translation initiation factor 5A
chrX_+_73639414 20.318 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr4_+_137468767 20.297 ENSMUST00000030547.8
ENSMUST00000171332.1
 Hspg2

perlecan (heparan sulfate proteoglycan 2)

chr6_-_148946146 19.300 ENSMUST00000132696.1
 Fam60a
family with sequence similarity 60, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 672 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 70.5 GO:0006414 translational elongation(GO:0006414)
10.4 62.4 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
4.7 56.9 GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209)
13.3 53.0 GO:0010288 response to lead ion(GO:0010288)
3.8 52.7 GO:0002192 IRES-dependent translational initiation(GO:0002192)
0.4 47.4 GO:0006626 protein targeting to mitochondrion(GO:0006626)
2.2 46.6 GO:0006220 pyrimidine nucleotide metabolic process(GO:0006220)
5.1 45.6 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
9.0 44.8 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.8 42.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.6 41.2 GO:0006405 RNA export from nucleus(GO:0006405)
1.1 39.2 GO:0030490 maturation of SSU-rRNA(GO:0030490)
7.7 38.5 GO:0015671 oxygen transport(GO:0015671)
2.6 38.5 GO:0010216 maintenance of DNA methylation(GO:0010216)
1.6 37.5 GO:0006907 pinocytosis(GO:0006907)
2.5 35.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
2.3 34.9 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.4 33.5 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
1.8 32.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.6 31.7 GO:0043966 histone H3 acetylation(GO:0043966)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 282 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 246.5 GO:0005730 nucleolus(GO:0005730)
0.1 176.1 GO:0005739 mitochondrion(GO:0005739)
2.3 94.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.9 90.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
6.4 64.4 GO:0005642 annulate lamellae(GO:0005642)
1.3 60.6 GO:0000791 euchromatin(GO:0000791)
0.9 58.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 55.5 GO:0005925 focal adhesion(GO:0005925)
0.8 54.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
8.7 52.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
3.7 51.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.9 46.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 45.1 GO:0005654 nucleoplasm(GO:0005654)
0.6 42.3 GO:0005581 collagen trimer(GO:0005581)
1.3 38.9 GO:0015030 Cajal body(GO:0015030)
1.3 38.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.6 37.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 37.6 GO:0016604 nuclear body(GO:0016604)
0.6 36.1 GO:0005643 nuclear pore(GO:0005643)
4.9 34.4 GO:0097422 tubular endosome(GO:0097422)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 438 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 174.5 GO:0044822 poly(A) RNA binding(GO:0044822)
0.4 81.7 GO:0003735 structural constituent of ribosome(GO:0003735)
3.2 76.1 GO:0003746 translation elongation factor activity(GO:0003746)
1.6 74.4 GO:0016831 carboxy-lyase activity(GO:0016831)
1.5 66.8 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
4.8 62.0 GO:0017070 U6 snRNA binding(GO:0017070)
1.1 58.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.8 53.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.7 51.1 GO:0051087 chaperone binding(GO:0051087)
1.3 49.3 GO:0008536 Ran GTPase binding(GO:0008536)
2.1 45.6 GO:0001784 phosphotyrosine binding(GO:0001784)
9.0 45.2 GO:0030492 hemoglobin binding(GO:0030492)
3.3 42.3 GO:0031386 protein tag(GO:0031386)
2.2 40.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
3.2 38.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.9 37.9 GO:0000049 tRNA binding(GO:0000049)
0.8 35.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
7.0 35.2 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
2.4 33.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
2.7 31.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)