Motif ID: Mbd2

Z-value: 1.450


Transcription factors associated with Mbd2:

Gene SymbolEntrez IDGene Name
Mbd2 ENSMUSG00000024513.10 Mbd2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mbd2mm10_v2_chr18_+_70568189_70568398-0.604.1e-07Click!


Activity profile for motif Mbd2.

activity profile for motif Mbd2


Sorted Z-values histogram for motif Mbd2

Sorted Z-values for motif Mbd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mbd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_108003414 20.493 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr5_-_115194283 20.008 ENSMUST00000112113.1
 Cabp1
calcium binding protein 1
chr5_+_37028329 14.680 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr5_+_36868467 11.901 ENSMUST00000031003.7
 Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr14_-_55116935 9.114 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr17_-_47924460 8.969 ENSMUST00000113262.1
 Foxp4
forkhead box P4
chr17_-_47924400 8.856 ENSMUST00000113263.1
ENSMUST00000097311.2
 Foxp4

forkhead box P4

chr1_+_74854954 8.838 ENSMUST00000160379.2
 Cdk5r2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr12_-_108003594 8.799 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr4_+_133039482 8.676 ENSMUST00000105914.1
 Ahdc1
AT hook, DNA binding motif, containing 1
chr11_-_94474088 8.192 ENSMUST00000107786.1
ENSMUST00000107791.1
ENSMUST00000103166.2
ENSMUST00000107792.1
ENSMUST00000100561.3
ENSMUST00000107793.1
ENSMUST00000107788.1
ENSMUST00000107790.1
ENSMUST00000107789.1
ENSMUST00000107785.1
ENSMUST00000021234.8
 Cacna1g










calcium channel, voltage-dependent, T type, alpha 1G subunit










chr13_-_52981027 7.882 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr5_-_135078224 7.196 ENSMUST00000067935.4
ENSMUST00000076203.2
 Vps37d

vacuolar protein sorting 37D (yeast)

chr12_-_79007276 7.194 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr2_+_28205648 7.162 ENSMUST00000102879.3
ENSMUST00000028177.4
 Olfm1

olfactomedin 1

chr17_-_45549655 7.119 ENSMUST00000180252.1
 Tmem151b
transmembrane protein 151B
chr11_+_104231390 7.103 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr2_+_157914618 7.006 ENSMUST00000109523.1
 Vstm2l
V-set and transmembrane domain containing 2-like
chr11_+_104231573 6.940 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr9_-_108190352 6.853 ENSMUST00000035208.7
 Bsn
bassoon

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 30.5 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
4.9 29.3 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.2 25.4 GO:0050885 neuromuscular process controlling balance(GO:0050885)
1.9 21.3 GO:1901250 regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250)
1.7 19.2 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 9.3 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.3 9.2 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 9.0 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
2.2 8.8 GO:0021586 pons maturation(GO:0021586)
0.3 7.9 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.2 6.9 GO:0035418 protein localization to synapse(GO:0035418)
1.3 6.5 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.4 6.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.4 5.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 5.8 GO:0032486 Rap protein signal transduction(GO:0032486)
0.3 5.8 GO:0055012 ventricular cardiac muscle cell differentiation(GO:0055012)
0.0 5.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.9 5.6 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.2 5.5 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 5.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 26.7 GO:0045298 tubulin complex(GO:0045298)
0.5 20.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 19.2 GO:0000139 Golgi membrane(GO:0000139)
0.4 18.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 15.1 GO:0070382 exocytic vesicle(GO:0070382)
0.6 11.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 11.5 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529) ribonucleoprotein complex(GO:1990904)
0.4 10.7 GO:0071565 nBAF complex(GO:0071565)
0.1 9.7 GO:0031225 anchored component of membrane(GO:0031225)
1.8 9.1 GO:0030314 junctional membrane complex(GO:0030314)
2.9 8.8 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 8.8 GO:0030175 filopodium(GO:0030175)
0.2 8.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.8 7.2 GO:0000813 ESCRT I complex(GO:0000813)
0.4 6.9 GO:0099738 cell cortex region(GO:0099738)
1.6 6.5 GO:1990032 parallel fiber(GO:1990032)
0.1 6.5 GO:0031201 SNARE complex(GO:0031201)
0.2 6.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 5.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 5.8 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 26.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.6 22.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.9 15.9 GO:0050811 GABA receptor binding(GO:0050811)
0.1 14.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 12.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.9 11.9 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.6 11.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 10.8 GO:0005509 calcium ion binding(GO:0005509)
0.7 9.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.2 9.8 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.3 8.5 GO:0071889 14-3-3 protein binding(GO:0071889)
2.0 8.2 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
1.3 7.8 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 7.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 7.4 GO:0045499 chemorepellent activity(GO:0045499)
0.4 6.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 6.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.9 6.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 6.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 6.1 GO:0051087 chaperone binding(GO:0051087)