Motif ID: Mecom

Z-value: 0.549


Transcription factors associated with Mecom:

Gene SymbolEntrez IDGene Name
Mecom ENSMUSG00000027684.10 Mecom



Activity profile for motif Mecom.

activity profile for motif Mecom


Sorted Z-values histogram for motif Mecom

Sorted Z-values for motif Mecom



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecom

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 12.530 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr7_-_103853199 5.311 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr1_+_152399824 4.061 ENSMUST00000044311.8
 Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr13_+_89540636 3.629 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr6_+_138140298 3.502 ENSMUST00000008684.4
 Mgst1
microsomal glutathione S-transferase 1
chr1_+_45311538 2.818 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr8_+_12385769 2.397 ENSMUST00000080795.8
 Gm5607
predicted gene 5607
chr10_+_3740348 2.352 ENSMUST00000120274.1
 Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr1_+_156838915 2.280 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr8_-_18741542 1.651 ENSMUST00000033846.6
 Angpt2
angiopoietin 2
chr16_-_38713235 1.486 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr10_-_27616895 1.454 ENSMUST00000092639.5
 Lama2
laminin, alpha 2
chr14_+_115042752 1.330 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr9_+_72806874 1.278 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr2_+_103970115 1.172 ENSMUST00000111143.1
ENSMUST00000138815.1
 Lmo2

LIM domain only 2

chr2_+_103970221 1.155 ENSMUST00000111140.2
ENSMUST00000111139.2
 Lmo2

LIM domain only 2

chr18_+_4994600 1.059 ENSMUST00000140448.1
 Svil
supervillin
chr16_-_29541483 1.043 ENSMUST00000057018.8
ENSMUST00000182627.1
 Atp13a4

ATPase type 13A4

chr2_+_71786923 1.023 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr5_+_66259890 1.001 ENSMUST00000065530.6
 Nsun7
NOL1/NOP2/Sun domain family, member 7
chr14_+_34375504 0.982 ENSMUST00000111908.1
 Mmrn2
multimerin 2
chr13_+_104287855 0.969 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr13_-_103764502 0.895 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr3_+_41742615 0.827 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chrX_-_139871637 0.744 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4

chr9_+_65890237 0.737 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr11_-_88718078 0.684 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chrX_-_145505175 0.667 ENSMUST00000143610.1
 Amot
angiomotin
chrX_-_145505136 0.638 ENSMUST00000112835.1
 Amot
angiomotin
chr2_+_103969528 0.624 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr4_+_41569775 0.611 ENSMUST00000102963.3
 Dnaic1
dynein, axonemal, intermediate chain 1
chr11_-_60046477 0.531 ENSMUST00000000310.7
ENSMUST00000102693.2
ENSMUST00000148512.1
 Pemt


phosphatidylethanolamine N-methyltransferase


chr18_-_43477764 0.494 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr3_+_106034661 0.457 ENSMUST00000170669.2
 Gm4540
predicted gene 4540
chrX_-_88760312 0.453 ENSMUST00000182943.1
 Gm27000
predicted gene, 27000
chr3_+_36552600 0.441 ENSMUST00000029269.5
ENSMUST00000136890.1
 Exosc9

exosome component 9

chr6_+_113392417 0.438 ENSMUST00000032414.4
ENSMUST00000038889.5
 Ttll3

tubulin tyrosine ligase-like family, member 3

chr1_-_69685937 0.410 ENSMUST00000027146.2
 Ikzf2
IKAROS family zinc finger 2
chr12_-_86079019 0.410 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chrX_-_113185485 0.402 ENSMUST00000026607.8
ENSMUST00000113388.2
 Chm

choroidermia

chr5_+_65131184 0.381 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr13_+_49544443 0.370 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr8_+_46490968 0.350 ENSMUST00000110372.1
ENSMUST00000130563.1
 Acsl1

acyl-CoA synthetase long-chain family member 1

chr5_+_134582690 0.303 ENSMUST00000023867.6
 Rfc2
replication factor C (activator 1) 2
chr9_+_105053239 0.255 ENSMUST00000035177.8
ENSMUST00000149243.1
 Mrpl3

mitochondrial ribosomal protein L3

chr4_+_11704439 0.242 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr15_-_48791933 0.226 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
 Csmd3


CUB and Sushi multiple domains 3


chr5_-_120467296 0.219 ENSMUST00000132916.1
 Sdsl
serine dehydratase-like
chrX_+_169879596 0.206 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr2_-_149798701 0.205 ENSMUST00000148202.1
ENSMUST00000139471.1
 Gm14133

predicted gene 14133

chrX_-_37110257 0.126 ENSMUST00000076265.6
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr10_+_5593718 0.123 ENSMUST00000051809.8
 Myct1
myc target 1
chr14_+_55854115 0.095 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing
chr9_+_115909455 0.090 ENSMUST00000119291.1
ENSMUST00000069651.6
 Gadl1

glutamate decarboxylase-like 1

chr6_-_29609607 0.055 ENSMUST00000115251.1
 Tnpo3
transportin 3
chr5_-_136198908 0.034 ENSMUST00000149151.1
ENSMUST00000151786.1
 Prkrip1

Prkr interacting protein 1 (IL11 inducible)

chr14_-_52020698 0.016 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr2_+_18672384 0.006 ENSMUST00000171845.1
ENSMUST00000061158.4
 Commd3

COMM domain containing 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
1.1 5.3 GO:0015671 oxygen transport(GO:0015671)
0.9 3.5 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.6 2.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.6 1.7 GO:0048014 Tie signaling pathway(GO:0048014)
0.3 1.3 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.3 1.5 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.3 1.0 GO:0035878 nail development(GO:0035878)
0.2 3.0 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.4 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1 0.4 GO:0018094 protein polyglycylation(GO:0018094)
0.1 1.0 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.4 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.1 0.5 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.1 1.0 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.7 GO:0019985 translesion synthesis(GO:0019985)
0.1 0.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.3 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 3.5 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.0 1.0 GO:0035904 aorta development(GO:0035904)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.3 GO:0005833 hemoglobin complex(GO:0005833)
0.2 2.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.6 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.0 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 1.5 GO:0005605 basal lamina(GO:0005605)
0.1 0.3 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 3.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 5.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 12.5 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
1.3 5.3 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.4 1.3 GO:0043532 angiostatin binding(GO:0043532)
0.2 1.0 GO:0038132 neuregulin binding(GO:0038132)
0.2 3.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 3.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.0 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.1 1.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.3 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 0.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 3.0 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.1 0.2 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.1 4.1 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 1.0 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)