Motif ID: Mecp2

Z-value: 2.305


Transcription factors associated with Mecp2:

Gene SymbolEntrez IDGene Name
Mecp2 ENSMUSG00000031393.10 Mecp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecp2mm10_v2_chrX_-_74085586_74085652-0.085.6e-01Click!


Activity profile for motif Mecp2.

activity profile for motif Mecp2


Sorted Z-values histogram for motif Mecp2

Sorted Z-values for motif Mecp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_87959560 14.120 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr11_-_68386821 13.493 ENSMUST00000021284.3
 Ntn1
netrin 1
chr6_-_72788952 13.471 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_25250720 11.559 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr11_-_89302545 11.518 ENSMUST00000061728.3
 Nog
noggin
chr8_-_90348343 10.649 ENSMUST00000109621.3
 Tox3
TOX high mobility group box family member 3
chr6_-_72789240 10.020 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr11_+_98412461 9.820 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr10_-_42583628 9.626 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr11_+_112782182 9.402 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr11_-_76027726 9.272 ENSMUST00000021207.6
 Fam101b
family with sequence similarity 101, member B
chr2_+_59612034 8.741 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr8_-_90348126 8.552 ENSMUST00000176034.1
ENSMUST00000176616.1
 Tox3

TOX high mobility group box family member 3

chr11_-_100850724 8.523 ENSMUST00000004143.2
 Stat5b
signal transducer and activator of transcription 5B
chr14_-_118237016 8.420 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21
chr7_+_65862029 8.272 ENSMUST00000055576.5
ENSMUST00000098391.4
 Pcsk6

proprotein convertase subtilisin/kexin type 6

chr11_-_68386974 8.268 ENSMUST00000135141.1
 Ntn1
netrin 1
chr2_+_91457501 8.235 ENSMUST00000028689.3
 Lrp4
low density lipoprotein receptor-related protein 4
chr12_+_3807017 8.215 ENSMUST00000020991.8
ENSMUST00000172509.1
 Dnmt3a

DNA methyltransferase 3A

chr1_-_181842334 8.146 ENSMUST00000005003.6
 Lbr
lamin B receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,163 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 27.3 GO:0046499 S-adenosylmethioninamine metabolic process(GO:0046499)
0.2 24.4 GO:0051028 mRNA transport(GO:0051028)
7.4 22.2 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
3.6 21.8 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.4 20.9 GO:0051225 spindle assembly(GO:0051225)
0.6 17.6 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.7 17.1 GO:0071539 protein localization to centrosome(GO:0071539)
2.8 17.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
3.3 16.4 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.7 15.5 GO:0006270 DNA replication initiation(GO:0006270)
0.5 15.1 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
1.6 14.3 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.4 13.7 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.3 13.0 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.9 13.0 GO:0035563 positive regulation of chromatin binding(GO:0035563)
1.8 12.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
2.5 12.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.2 12.4 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
3.0 11.8 GO:0000255 allantoin metabolic process(GO:0000255)
3.8 11.4 GO:0060221 retinal rod cell differentiation(GO:0060221)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 366 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 151.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 67.8 GO:0005730 nucleolus(GO:0005730)
0.1 66.6 GO:0005654 nucleoplasm(GO:0005654)
0.2 47.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 45.0 GO:1903561 extracellular organelle(GO:0043230) extracellular vesicle(GO:1903561)
0.4 38.7 GO:0017053 transcriptional repressor complex(GO:0017053)
1.3 30.9 GO:0001741 XY body(GO:0001741)
0.4 26.7 GO:0005643 nuclear pore(GO:0005643)
2.0 26.4 GO:0043219 lateral loop(GO:0043219)
0.4 22.4 GO:0005844 polysome(GO:0005844)
0.2 22.4 GO:0043296 apical junction complex(GO:0043296)
0.1 21.8 GO:0005925 focal adhesion(GO:0005925)
0.2 21.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.5 20.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 20.8 GO:0000922 spindle pole(GO:0000922)
0.2 19.2 GO:0000792 heterochromatin(GO:0000792)
0.2 18.3 GO:0005604 basement membrane(GO:0005604)
0.1 17.5 GO:0005694 chromosome(GO:0005694)
0.2 17.4 GO:0005681 spliceosomal complex(GO:0005681)
1.3 17.0 GO:0016600 flotillin complex(GO:0016600)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 652 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 51.3 GO:0000975 regulatory region DNA binding(GO:0000975)
0.4 47.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 46.7 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
1.4 30.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 28.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
3.4 27.3 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 23.4 GO:0044822 poly(A) RNA binding(GO:0044822)
1.3 22.4 GO:0017166 vinculin binding(GO:0017166)
0.4 22.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.1 21.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
2.7 19.2 GO:0034056 estrogen response element binding(GO:0034056)
0.5 17.2 GO:0005109 frizzled binding(GO:0005109)
0.2 17.1 GO:0005178 integrin binding(GO:0005178)
1.7 16.8 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.6 16.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.4 16.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.9 16.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 15.5 GO:0030332 cyclin binding(GO:0030332)
0.3 13.9 GO:0035064 methylated histone binding(GO:0035064)
0.4 13.5 GO:0004177 aminopeptidase activity(GO:0004177)