Motif ID: Mef2c

Z-value: 0.891


Transcription factors associated with Mef2c:

Gene SymbolEntrez IDGene Name
Mef2c ENSMUSG00000005583.10 Mef2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83573577_835736070.653.4e-08Click!


Activity profile for motif Mef2c.

activity profile for motif Mef2c


Sorted Z-values histogram for motif Mef2c

Sorted Z-values for motif Mef2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 175 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_69785507 9.419 ENSMUST00000182993.1
 Ank3
ankyrin 3, epithelial
chr13_+_83573577 8.624 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chrX_-_51681703 7.690 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chrX_-_51681856 7.418 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr13_+_16011851 6.438 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr16_+_7069825 5.910 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr8_-_109251698 5.774 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr5_-_122002340 5.213 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr8_+_45658666 5.160 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr1_-_12991109 5.097 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr19_+_4003334 4.980 ENSMUST00000025806.3
 Doc2g
double C2, gamma
chr7_+_91090697 4.902 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr8_+_45658731 4.886 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr8_+_45658273 4.863 ENSMUST00000153798.1
 Sorbs2
sorbin and SH3 domain containing 2
chr7_+_91090728 4.793 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr4_+_130308595 4.692 ENSMUST00000070532.7
 Fabp3
fatty acid binding protein 3, muscle and heart
chr3_-_158562199 4.671 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chr9_-_112232449 4.502 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr10_+_69925766 4.349 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chr3_-_56183678 4.347 ENSMUST00000029374.6
 Nbea
neurobeachin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 25.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.5 15.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.7 9.7 GO:0045161 neuronal ion channel clustering(GO:0045161)
2.9 8.6 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 8.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.2 6.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.3 6.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 6.3 GO:0008209 androgen metabolic process(GO:0008209)
0.0 5.6 GO:0048813 dendrite morphogenesis(GO:0048813)
0.2 5.2 GO:0007614 short-term memory(GO:0007614)
0.4 5.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 5.0 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.2 5.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.2 4.7 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.4 4.7 GO:0042572 retinol metabolic process(GO:0042572)
0.0 4.7 GO:0010976 positive regulation of neuron projection development(GO:0010976)
0.4 4.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.5 4.3 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 4.3 GO:0007613 memory(GO:0007613)
0.5 4.2 GO:0016081 synaptic vesicle docking(GO:0016081)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 25.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 10.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 10.6 GO:0016607 nuclear speck(GO:0016607)
0.5 9.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
2.1 6.4 GO:0043512 inhibin A complex(GO:0043512)
0.1 6.2 GO:0032587 ruffle membrane(GO:0032587)
0.9 6.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 6.0 GO:0045202 synapse(GO:0045202)
0.1 5.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 5.0 GO:0097060 synaptic membrane(GO:0097060)
0.0 5.0 GO:0098793 presynapse(GO:0098793)
0.2 4.7 GO:0043194 axon initial segment(GO:0043194)
0.1 4.5 GO:0044291 cell-cell contact zone(GO:0044291)
1.4 4.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 3.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 3.6 GO:0048786 presynaptic active zone(GO:0048786)
0.1 3.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 2.6 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.1 2.3 GO:0016528 sarcoplasm(GO:0016528)
0.1 2.2 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 25.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.5 15.1 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 14.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.5 9.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.8 8.6 GO:0003680 AT DNA binding(GO:0003680)
1.2 7.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 6.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.9 6.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.5 5.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 5.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 4.9 GO:0030674 protein binding, bridging(GO:0030674)
0.9 4.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.7 4.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 4.5 GO:0008083 growth factor activity(GO:0008083)
1.4 4.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 4.3 GO:0051018 protein kinase A binding(GO:0051018)
0.0 4.3 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.4 4.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 4.2 GO:0015631 tubulin binding(GO:0015631)
0.4 3.8 GO:0019534 toxin transporter activity(GO:0019534)