Motif ID: Mef2d_Mef2a

Z-value: 1.149

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2amm10_v2_chr7_-_67372846_673728580.798.7e-14Click!
Mef2dmm10_v2_chr3_+_88142328_881424830.737.8e-11Click!


Activity profile for motif Mef2d_Mef2a.

activity profile for motif Mef2d_Mef2a


Sorted Z-values histogram for motif Mef2d_Mef2a

Sorted Z-values for motif Mef2d_Mef2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83573577 16.282 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr11_+_31872100 15.107 ENSMUST00000020543.6
ENSMUST00000109412.2
 Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr1_-_134234492 12.289 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr13_+_23934434 11.924 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr3_-_56183678 11.119 ENSMUST00000029374.6
 Nbea
neurobeachin
chr19_+_38264761 10.594 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr16_+_7069825 10.509 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_-_168712853 9.766 ENSMUST00000123156.1
ENSMUST00000156555.1
 Atp9a

ATPase, class II, type 9A

chr2_-_33371486 9.295 ENSMUST00000113165.1
 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr4_+_144892813 9.108 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_-_33371400 9.077 ENSMUST00000113164.1
ENSMUST00000091039.2
ENSMUST00000042615.6
 Ralgps1


Ral GEF with PH domain and SH3 binding motif 1


chr6_-_136171722 9.048 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr16_+_45093611 8.860 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr13_-_23934156 8.741 ENSMUST00000052776.2
 Hist1h2ba
histone cluster 1, H2ba
chr5_+_66745835 8.382 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr1_-_172297989 8.291 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr9_+_34904913 8.181 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr18_-_25753852 8.166 ENSMUST00000025117.6
ENSMUST00000115816.2
 Celf4

CUGBP, Elav-like family member 4

chr11_-_102218923 7.979 ENSMUST00000131254.1
 Hdac5
histone deacetylase 5
chr7_+_91090697 7.884 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 20.8 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
1.8 19.9 GO:0042572 retinol metabolic process(GO:0042572)
3.7 18.4 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
1.2 17.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 16.9 GO:0006342 chromatin silencing(GO:0006342)
5.4 16.3 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.1 15.6 GO:0045161 neuronal ion channel clustering(GO:0045161)
4.5 13.4 GO:0001928 regulation of exocyst assembly(GO:0001928)
4.1 12.3 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.1 11.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 11.2 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
1.8 10.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 10.2 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
0.2 9.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.5 9.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.6 9.0 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
1.8 8.8 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.7 8.7 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 8.5 GO:0034605 cellular response to heat(GO:0034605)
1.1 8.4 GO:0016081 synaptic vesicle docking(GO:0016081)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 28.0 GO:0005802 trans-Golgi network(GO:0005802)
1.2 21.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.8 15.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 15.3 GO:0031225 anchored component of membrane(GO:0031225)
2.1 15.0 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.2 14.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 13.3 GO:0016607 nuclear speck(GO:0016607)
0.8 12.3 GO:0032279 asymmetric synapse(GO:0032279)
0.4 12.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 9.9 GO:0043198 dendritic shaft(GO:0043198)
0.8 9.0 GO:0043083 synaptic cleft(GO:0043083)
0.6 8.9 GO:0005614 interstitial matrix(GO:0005614)
1.2 8.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 7.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 7.5 GO:0014704 intercalated disc(GO:0014704)
0.4 7.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 7.2 GO:0045171 intercellular bridge(GO:0045171)
0.1 6.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.8 6.8 GO:0001520 outer dense fiber(GO:0001520)
1.3 6.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 22.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
3.3 19.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.2 17.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.3 16.8 GO:0051018 protein kinase A binding(GO:0051018)
0.7 15.6 GO:0004385 guanylate kinase activity(GO:0004385)
2.1 15.0 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 13.8 GO:0008017 microtubule binding(GO:0008017)
0.7 13.0 GO:0030275 LRR domain binding(GO:0030275)
1.8 12.3 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 11.7 GO:0003729 mRNA binding(GO:0003729)
1.0 11.4 GO:0003680 AT DNA binding(GO:0003680)
1.9 11.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.5 10.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.4 10.6 GO:0042805 actinin binding(GO:0042805)
0.3 10.6 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.9 10.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.3 8.9 GO:0001968 fibronectin binding(GO:0001968)
2.2 8.8 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.0 8.3 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239)
0.1 7.3 GO:0030674 protein binding, bridging(GO:0030674)