Motif ID: Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 0.629

Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6:

Gene SymbolEntrez IDGene Name
Barx1 ENSMUSG00000021381.4 Barx1
Dlx6 ENSMUSG00000029754.7 Dlx6
Lhx9 ENSMUSG00000019230.8 Lhx9
Msx1 ENSMUSG00000048450.10 Msx1
Rax ENSMUSG00000024518.3 Rax

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx9mm10_v2_chr1_-_138848576_138848603-0.563.5e-06Click!
Raxmm10_v2_chr18_-_65939048_65939089-0.541.0e-05Click!
Msx1mm10_v2_chr5_-_37824580_37824584-0.302.3e-02Click!
Dlx6mm10_v2_chr6_+_6863269_6863334-0.211.1e-01Click!


Activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6.

activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6


Sorted Z-values histogram for motif Msx1_Lhx9_Barx1_Rax_Dlx6

Sorted Z-values for motif Msx1_Lhx9_Barx1_Rax_Dlx6



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Top targets:


Showing 1 to 20 of 185 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_136171722 8.442 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr5_-_134747241 8.038 ENSMUST00000015138.9
 Eln
elastin
chr5_-_62766153 7.773 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_+_118478344 7.750 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 7.503 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr8_+_54954728 6.032 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr2_+_116067213 5.750 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr4_-_14621805 5.101 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr16_+_45093611 5.032 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr9_-_40346290 4.842 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr7_+_126950518 4.616 ENSMUST00000106335.1
ENSMUST00000146017.1
 Sez6l2

seizure related 6 homolog like 2

chr1_-_155417394 4.333 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr19_+_26749726 4.003 ENSMUST00000175842.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_155417283 3.959 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr7_+_126950687 3.868 ENSMUST00000106333.1
 Sez6l2
seizure related 6 homolog like 2
chr2_-_116067391 3.624 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr16_+_42907563 3.180 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr4_-_14621494 3.119 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr18_+_23415400 3.069 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr2_-_45117349 3.028 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 15.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 11.3 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
1.4 9.5 GO:0019532 oxalate transport(GO:0019532)
0.1 8.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.6 8.4 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
1.4 8.3 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 6.0 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.6 5.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 4.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 3.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 3.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 3.1 GO:0001553 luteinization(GO:0001553)
1.0 3.0 GO:0050975 sensory perception of touch(GO:0050975)
0.6 3.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.5 3.0 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 2.9 GO:0048305 immunoglobulin secretion(GO:0048305)
0.2 2.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.9 2.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.8 2.5 GO:0021852 pyramidal neuron migration(GO:0021852)
0.6 2.5 GO:0043490 malate-aspartate shuttle(GO:0043490)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 8.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 8.2 GO:0016323 basolateral plasma membrane(GO:0016323)
2.7 8.0 GO:0071953 elastic fiber(GO:0071953)
0.0 7.9 GO:0043025 neuronal cell body(GO:0043025)
0.3 7.4 GO:0071565 nBAF complex(GO:0071565)
0.3 5.0 GO:0005614 interstitial matrix(GO:0005614)
0.3 4.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 4.1 GO:0044295 axonal growth cone(GO:0044295)
0.2 3.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 3.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.9 GO:0005768 endosome(GO:0005768)
0.1 2.6 GO:0030673 axolemma(GO:0030673)
0.0 2.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 2.5 GO:0043205 fibril(GO:0043205)
0.2 2.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.7 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.5 GO:1904115 axon cytoplasm(GO:1904115)
0.1 1.4 GO:0031045 dense core granule(GO:0031045)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 9.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.9 9.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.8 8.4 GO:0031749 D2 dopamine receptor binding(GO:0031749)
1.0 8.3 GO:0001618 virus receptor activity(GO:0001618)
0.2 7.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 6.0 GO:0005262 calcium channel activity(GO:0005262)
0.2 5.0 GO:0001968 fibronectin binding(GO:0001968)
0.1 4.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 3.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 3.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 3.0 GO:0070412 R-SMAD binding(GO:0070412)
0.3 2.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 2.5 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 2.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 2.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 1.7 GO:0016208 AMP binding(GO:0016208)
0.2 1.4 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 1.4 GO:0042056 chemoattractant activity(GO:0042056)