Motif ID: Msx2_Hoxd4

Z-value: 0.869

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.181.8e-01Click!


Activity profile for motif Msx2_Hoxd4.

activity profile for motif Msx2_Hoxd4


Sorted Z-values histogram for motif Msx2_Hoxd4

Sorted Z-values for motif Msx2_Hoxd4



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Showing 1 to 20 of 142 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 19.964 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_62765618 10.559 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_159737510 7.862 ENSMUST00000111669.3
 Tnr
tenascin R
chr6_-_36811361 6.729 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr3_+_62419668 6.540 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr2_-_63184253 5.418 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr14_-_88471396 5.031 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr15_-_37459327 4.586 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr12_+_74297474 4.578 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr12_+_38783503 4.302 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr1_-_163725123 3.929 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr2_-_63184170 3.451 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr3_-_66296807 3.323 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1
chr15_+_21111452 3.299 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr2_+_4017727 2.828 ENSMUST00000177457.1
 Frmd4a
FERM domain containing 4A
chr17_-_90088343 2.824 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr15_+_92597104 2.799 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr6_-_136171722 2.646 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr1_+_165788681 2.591 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr1_-_190170671 2.438 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 GO:0051291 protein heterooligomerization(GO:0051291)
2.6 7.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 6.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
2.2 6.7 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 6.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 6.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 4.7 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 3.9 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
1.2 3.6 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 3.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.6 2.8 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 2.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 2.7 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 2.6 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 2.4 GO:0019915 lipid storage(GO:0019915)
0.3 2.3 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 2.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 2.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.4 2.2 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 2.2 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.9 GO:0005887 integral component of plasma membrane(GO:0005887)
2.6 7.9 GO:0072534 perineuronal net(GO:0072534)
0.1 6.7 GO:0031594 neuromuscular junction(GO:0031594)
1.2 4.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 2.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.7 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.6 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.4 GO:0005811 lipid particle(GO:0005811)
0.1 2.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 2.1 GO:0071439 clathrin complex(GO:0071439)
0.1 2.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 1.8 GO:0070688 MLL5-L complex(GO:0070688)
0.2 1.6 GO:0044327 dendritic spine head(GO:0044327)
0.0 1.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.4 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 1.2 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.3 1.0 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 32.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 8.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.5 7.9 GO:0046625 sphingolipid binding(GO:0046625)
0.0 7.9 GO:0005509 calcium ion binding(GO:0005509)
0.2 6.9 GO:0043014 alpha-tubulin binding(GO:0043014)
2.2 6.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.5 3.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.5 3.6 GO:0050693 LBD domain binding(GO:0050693)
0.0 3.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.2 2.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 2.6 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 2.6 GO:0030674 protein binding, bridging(GO:0030674)
0.1 2.4 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.3 2.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 2.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 2.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 2.2 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.2 GO:0030552 cAMP binding(GO:0030552)
0.1 2.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.8 GO:0017137 Rab GTPase binding(GO:0017137)