Motif ID: Msx2_Hoxd4
Z-value: 0.869
Transcription factors associated with Msx2_Hoxd4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Msx2 | ENSMUSG00000021469.8 | Msx2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Msx2 | mm10_v2_chr13_-_53473074_53473074 | -0.18 | 1.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.9 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 2.2 | 6.7 | GO:1904395 | regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 1.2 | 3.6 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.6 | 1.8 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.6 | 2.8 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.5 | 1.6 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.5 | 1.6 | GO:0030827 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 0.4 | 1.1 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.4 | 2.2 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.3 | 2.3 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.3 | 1.0 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) |
| 0.3 | 0.3 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
| 0.3 | 6.5 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.2 | 0.9 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.2 | 1.1 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.2 | 1.5 | GO:0071732 | cellular response to nitric oxide(GO:0071732) |
| 0.2 | 2.6 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
| 0.2 | 1.4 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.2 | 2.1 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.2 | 2.0 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 2.3 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.1 | 0.2 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.1 | 1.3 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 3.9 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
| 0.1 | 0.6 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.1 | 0.3 | GO:0032289 | central nervous system myelin formation(GO:0032289) |
| 0.1 | 1.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.1 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 3.0 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.1 | 1.0 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.1 | 0.8 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 1.5 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.1 | 2.3 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.1 | 2.1 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.1 | 1.2 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.1 | 6.9 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 6.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 1.6 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.1 | 1.3 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.1 | 0.9 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.1 | 1.4 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
| 0.1 | 2.0 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 0.1 | 4.7 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.1 | 0.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.7 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.1 | 0.9 | GO:0060746 | parental behavior(GO:0060746) |
| 0.1 | 2.7 | GO:1904030 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.1 | 2.8 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 0.7 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 8.9 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 0.8 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 1.2 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 2.4 | GO:0019915 | lipid storage(GO:0019915) |
| 0.0 | 0.6 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 0.6 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.0 | 0.5 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 1.7 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.5 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.0 | 0.2 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.0 | 0.7 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.4 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) |
| 0.0 | 0.1 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.0 | 2.2 | GO:0098780 | mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780) |
| 0.0 | 0.1 | GO:0046689 | response to mercury ion(GO:0046689) |
| 0.0 | 0.1 | GO:0015886 | heme transport(GO:0015886) |
| 0.0 | 1.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.1 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 0.0 | 0.5 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.9 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.2 | 4.7 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.3 | 1.0 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.2 | 2.6 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 2.1 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.2 | 1.8 | GO:0070688 | MLL5-L complex(GO:0070688) |
| 0.2 | 0.8 | GO:0031673 | H zone(GO:0031673) |
| 0.2 | 1.6 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.2 | 0.5 | GO:0055087 | Ski complex(GO:0055087) |
| 0.1 | 2.0 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 0.6 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.1 | 6.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 2.2 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 1.4 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 0.1 | 0.2 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.1 | 0.5 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 1.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 2.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 2.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.5 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.2 | GO:0000235 | astral microtubule(GO:0000235) |
| 0.0 | 0.6 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.0 | 1.0 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 1.0 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 1.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 2.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.3 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.2 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 1.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.1 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.0 | 0.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 9.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 1.1 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.7 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.7 | 32.4 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.5 | 7.9 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.5 | 3.7 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.5 | 3.6 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.4 | 8.9 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.3 | 2.3 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.3 | 1.5 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.3 | 1.7 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.3 | 2.6 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.2 | 2.8 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.2 | 6.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 1.3 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 1.1 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 1.5 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 1.6 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 2.1 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 0.8 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.1 | 2.4 | GO:0052771 | coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771) |
| 0.1 | 2.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 2.3 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 1.2 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 1.4 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) |
| 0.1 | 2.2 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 0.9 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 1.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 0.5 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.0 | 1.6 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.0 | 0.6 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.9 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.2 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.4 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 1.1 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 2.6 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 0.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.8 | GO:0008748 | N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693) |
| 0.0 | 3.3 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.0 | 0.6 | GO:0004120 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715) |
| 0.0 | 2.3 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.1 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.0 | 1.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.7 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 1.0 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 7.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.1 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.0 | 1.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
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