Motif ID: Mtf1

Z-value: 1.223


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.382.7e-03Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_94172618 43.037 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr8_+_94179089 27.276 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr11_-_32222233 17.441 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr11_+_63133068 14.834 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr11_+_63132569 14.146 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr1_+_135729147 10.066 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr1_+_191906743 8.592 ENSMUST00000044954.6
 Slc30a1
solute carrier family 30 (zinc transporter), member 1
chr6_-_39118211 7.449 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr14_-_26170283 6.954 ENSMUST00000100809.4
 Plac9b
placenta specific 9b
chr4_+_134496996 6.829 ENSMUST00000095074.3
 Paqr7
progestin and adipoQ receptor family member VII
chr12_+_24572276 5.638 ENSMUST00000085553.5
 Grhl1
grainyhead-like 1 (Drosophila)
chr5_+_105415738 4.906 ENSMUST00000112707.1
 Lrrc8b
leucine rich repeat containing 8 family, member B
chr9_-_14381242 4.550 ENSMUST00000167549.1
 Endod1
endonuclease domain containing 1
chr1_+_131867224 4.006 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr4_+_129984833 3.702 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr4_+_129985098 3.646 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr8_-_54529951 3.403 ENSMUST00000067476.8
 Spcs3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr7_+_119793987 3.309 ENSMUST00000033218.8
ENSMUST00000106520.1
 2610020H08Rik

RIKEN cDNA 2610020H08 gene

chr3_-_94412883 3.248 ENSMUST00000181305.1
 1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr7_+_119794102 3.236 ENSMUST00000084644.2
 2610020H08Rik
RIKEN cDNA 2610020H08 gene
chr3_-_121815212 3.216 ENSMUST00000029770.5
 Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr1_-_166002613 3.215 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr10_+_70245083 3.118 ENSMUST00000046807.6
 Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr17_+_71673255 3.080 ENSMUST00000097284.3
 Fam179a
family with sequence similarity 179, member A
chr1_-_166002591 2.963 ENSMUST00000111429.4
ENSMUST00000176800.1
 Pou2f1

POU domain, class 2, transcription factor 1

chr13_+_23934434 2.727 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr8_+_13159135 2.620 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr1_+_167618246 2.616 ENSMUST00000111380.1
 Rxrg
retinoid X receptor gamma
chr13_-_45964964 2.561 ENSMUST00000180110.1
ENSMUST00000091628.3
ENSMUST00000167708.2
 Atxn1


ataxin 1


chr3_+_107895916 2.326 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr7_+_132610620 2.195 ENSMUST00000033241.5
 Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr18_+_11839220 2.127 ENSMUST00000171109.1
ENSMUST00000046948.8
 Cables1

CDK5 and Abl enzyme substrate 1

chr5_-_125341043 2.101 ENSMUST00000111390.1
ENSMUST00000086075.6
 Scarb1

scavenger receptor class B, member 1

chr9_-_56635624 2.081 ENSMUST00000114256.1
 Lingo1
leucine rich repeat and Ig domain containing 1
chr19_-_4839286 2.015 ENSMUST00000037246.5
 Ccs
copper chaperone for superoxide dismutase
chr9_-_112187898 1.924 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr2_-_130664565 1.904 ENSMUST00000089559.4
 Ddrgk1
DDRGK domain containing 1
chr3_+_107895821 1.895 ENSMUST00000004134.4
 Gstm5
glutathione S-transferase, mu 5
chr7_-_43313063 1.892 ENSMUST00000135130.1
ENSMUST00000139061.1
 Zfp715

zinc finger protein 715

chr1_-_169531447 1.863 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_-_173119402 1.841 ENSMUST00000094287.3
ENSMUST00000179693.1
 Ctcfl

CCCTC-binding factor (zinc finger protein)-like

chr1_-_169531343 1.774 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_+_78175898 1.750 ENSMUST00000180974.1
 C920006O11Rik
RIKEN cDNA C920006O11 gene
chr15_-_58214882 1.738 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr7_-_119793958 1.643 ENSMUST00000106523.1
ENSMUST00000063902.7
ENSMUST00000150844.1
 Eri2


exoribonuclease 2


chr3_+_107896247 1.500 ENSMUST00000169365.1
 Gstm5
glutathione S-transferase, mu 5
chr19_-_4615453 1.297 ENSMUST00000053597.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr13_-_23934156 1.284 ENSMUST00000052776.2
 Hist1h2ba
histone cluster 1, H2ba
chr19_-_4615647 1.272 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr12_-_4592927 1.160 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr2_+_91237110 1.143 ENSMUST00000181191.1
 A330069E16Rik
RIKEN cDNA A330069E16 gene
chr19_-_41263931 1.130 ENSMUST00000025989.8
 Tm9sf3
transmembrane 9 superfamily member 3
chr16_-_91597636 1.129 ENSMUST00000023686.8
 Tmem50b
transmembrane protein 50B
chr6_+_145746739 1.018 ENSMUST00000111704.1
 Rassf8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr18_-_84589491 1.007 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr10_-_39899238 0.944 ENSMUST00000178563.1
 AA474331
expressed sequence AA474331
chr12_+_103532435 0.884 ENSMUST00000021631.5
 Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr7_-_43313233 0.857 ENSMUST00000012796.7
ENSMUST00000107986.2
 Zfp715

zinc finger protein 715

chr6_+_90619241 0.827 ENSMUST00000032177.8
 Slc41a3
solute carrier family 41, member 3
chr2_+_150323702 0.742 ENSMUST00000133235.2
 Gm10130
predicted gene 10130
chr8_+_92827273 0.641 ENSMUST00000034187.7
 Mmp2
matrix metallopeptidase 2
chr1_+_75400070 0.625 ENSMUST00000113589.1
 Speg
SPEG complex locus
chr1_+_179668202 0.613 ENSMUST00000040538.3
 Sccpdh
saccharopine dehydrogenase (putative)
chr5_+_115506668 0.504 ENSMUST00000067268.8
ENSMUST00000086523.3
 Pxn

paxillin

chr5_-_123749393 0.460 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
 Rsrc2


arginine/serine-rich coiled-coil 2


chr2_-_91236877 0.448 ENSMUST00000111352.1
 Ddb2
damage specific DNA binding protein 2
chr5_-_123749371 0.446 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
 Rsrc2


arginine/serine-rich coiled-coil 2


chr17_-_56716788 0.396 ENSMUST00000067931.5
 Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr8_-_70776650 0.335 ENSMUST00000034296.8
 Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr10_+_77606571 0.320 ENSMUST00000099538.5
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr11_+_94741782 0.284 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr10_+_81136223 0.282 ENSMUST00000048128.8
 Zbtb7a
zinc finger and BTB domain containing 7a
chr10_+_20952547 0.212 ENSMUST00000105525.4
 Ahi1
Abelson helper integration site 1
chr7_-_141539784 0.174 ENSMUST00000118694.1
ENSMUST00000153191.1
ENSMUST00000166082.1
ENSMUST00000026586.6
 Chid1



chitinase domain containing 1



chr5_+_57718021 0.152 ENSMUST00000094783.3
ENSMUST00000068110.7
 Pcdh7

protocadherin 7

chr4_-_93335510 0.145 ENSMUST00000066774.4
 Tusc1
tumor suppressor candidate 1
chr2_+_119112793 0.129 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr18_+_14424821 0.042 ENSMUST00000069552.5
 Gm5160
predicted gene 5160
chr10_+_77606217 0.026 ENSMUST00000129492.1
ENSMUST00000141228.2
 Sumo3

SMT3 suppressor of mif two 3 homolog 3 (yeast)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.0 70.3 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
8.6 8.6 GO:0061687 detoxification of inorganic compound(GO:0061687)
1.6 29.0 GO:0032060 bleb assembly(GO:0032060)
1.1 3.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.9 5.6 GO:0002934 desmosome organization(GO:0002934)
0.9 6.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.9 2.6 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.8 5.7 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.7 2.1 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.6 1.7 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.4 2.6 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 1.9 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.3 3.1 GO:0046415 urate metabolic process(GO:0046415)
0.3 17.4 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.3 1.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 1.6 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.2 0.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 10.1 GO:0070527 platelet aggregation(GO:0070527)
0.1 2.1 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.1 3.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 2.0 GO:0019430 removal of superoxide radicals(GO:0019430)
0.1 6.8 GO:0048477 oogenesis(GO:0048477)
0.1 2.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.2 GO:0030862 regulation of polarized epithelial cell differentiation(GO:0030860) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.1 0.2 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.9 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 1.8 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 1.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.3 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 4.9 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 2.7 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.5 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 0.3 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 2.1 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 29.0 GO:0043218 compact myelin(GO:0043218)
0.9 2.6 GO:0044194 cytolytic granule(GO:0044194)
0.6 3.6 GO:0031262 Ndc80 complex(GO:0031262)
0.4 5.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 2.6 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 2.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 3.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.4 GO:0045098 type III intermediate filament(GO:0045098)
0.1 8.6 GO:0030315 T-tubule(GO:0030315)
0.1 17.3 GO:0000139 Golgi membrane(GO:0000139)
0.1 25.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 1.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 10.9 GO:0005925 focal adhesion(GO:0005925)
0.0 1.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.7 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 0.9 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 6.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0000800 lateral element(GO:0000800)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.6 3.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.6 8.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.5 29.3 GO:0005507 copper ion binding(GO:0005507)
0.4 2.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.4 7.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 2.6 GO:0034046 poly(G) binding(GO:0034046)
0.3 2.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 17.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 5.7 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 6.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 3.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 5.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.2 GO:0004568 chitinase activity(GO:0004568)
0.1 2.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 52.2 GO:0008270 zinc ion binding(GO:0008270)
0.0 4.7 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.4 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.6 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) NADPH:sulfur oxidoreductase activity(GO:0043914) epoxyqueuosine reductase activity(GO:0052693)
0.0 0.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.8 GO:0042393 histone binding(GO:0042393)
0.0 0.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)