Motif ID: Nanog

Z-value: 0.852


Transcription factors associated with Nanog:

Gene SymbolEntrez IDGene Name
Nanog ENSMUSG00000012396.6 Nanog

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nanogmm10_v2_chr6_+_122707489_1227076080.436.7e-04Click!


Activity profile for motif Nanog.

activity profile for motif Nanog


Sorted Z-values histogram for motif Nanog

Sorted Z-values for motif Nanog



Network of associatons between targets according to the STRING database.



First level regulatory network of Nanog

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 5.815 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr18_-_78206408 5.640 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr3_+_62419668 4.914 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr19_-_36736653 4.662 ENSMUST00000087321.2
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr10_+_58394381 4.439 ENSMUST00000105468.1
Lims1
LIM and senescent cell antigen-like domains 1
chr15_+_9436028 4.165 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr10_+_58394361 4.065 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr14_+_65970610 4.031 ENSMUST00000127387.1
Clu
clusterin
chr4_-_109665249 4.016 ENSMUST00000063531.4
Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr1_-_52490736 3.946 ENSMUST00000170269.1
Nab1
Ngfi-A binding protein 1
chr4_+_20008357 3.907 ENSMUST00000117632.1
ENSMUST00000098244.1
Ttpa

tocopherol (alpha) transfer protein

chr10_-_25200110 3.845 ENSMUST00000100012.2
Akap7
A kinase (PRKA) anchor protein 7
chr13_-_85127514 3.771 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr2_+_116067213 3.631 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr14_+_65971049 3.538 ENSMUST00000128539.1
Clu
clusterin
chr2_+_62664279 3.449 ENSMUST00000028257.2
Gca
grancalcin
chr11_-_109298066 3.319 ENSMUST00000106706.1
Rgs9
regulator of G-protein signaling 9
chr14_+_65970804 3.266 ENSMUST00000138191.1
Clu
clusterin
chr18_-_35215008 3.235 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr11_-_109298121 3.148 ENSMUST00000020920.3
Rgs9
regulator of G-protein signaling 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 10.8 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
2.1 8.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 8.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.4 5.9 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
1.5 5.8 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.8 5.6 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.7 5.0 GO:0015808 L-alanine transport(GO:0015808)
0.2 4.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 4.7 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 4.0 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 4.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
1.0 3.9 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 3.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 3.9 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.6 3.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 3.4 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.1 3.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 3.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 3.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.4 2.9 GO:1903895 negative regulation of IRE1-mediated unfolded protein response(GO:1903895)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 10.8 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.2 8.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 8.2 GO:0005911 cell-cell junction(GO:0005911)
0.1 5.0 GO:0005882 intermediate filament(GO:0005882)
0.5 4.7 GO:0042587 glycogen granule(GO:0042587)
0.1 4.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 3.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 3.3 GO:0005938 cell cortex(GO:0005938)
0.0 3.3 GO:0005770 late endosome(GO:0005770)
0.1 3.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.7 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.1 GO:0001891 phagocytic cup(GO:0001891)
0.4 2.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.0 GO:0097386 glial cell projection(GO:0097386)
0.0 2.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.0 GO:0016607 nuclear speck(GO:0016607)
0.4 1.9 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.0 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.7 GO:0005096 GTPase activator activity(GO:0005096)
0.5 10.6 GO:0051787 misfolded protein binding(GO:0051787)
0.0 6.9 GO:0019901 protein kinase binding(GO:0019901)
0.0 6.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9 5.6 GO:0015265 urea channel activity(GO:0015265)
0.6 5.0 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1 4.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 4.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.3 4.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 4.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 3.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 3.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 3.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 3.3 GO:0042393 histone binding(GO:0042393)
0.2 3.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 3.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 2.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.4 2.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.3 2.4 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 2.3 GO:0070412 R-SMAD binding(GO:0070412)