Motif ID: Nfatc1

Z-value: 5.087


Transcription factors associated with Nfatc1:

Gene SymbolEntrez IDGene Name
Nfatc1 ENSMUSG00000033016.9 Nfatc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc1mm10_v2_chr18_-_80713062_80713080-0.331.1e-02Click!


Activity profile for motif Nfatc1.

activity profile for motif Nfatc1


Sorted Z-values histogram for motif Nfatc1

Sorted Z-values for motif Nfatc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3000922 210.313 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3004457 200.427 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3027439 196.650 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3013140 186.802 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 178.672 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3037111 171.078 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3025417 164.197 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3034599 159.282 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3036877 158.733 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3005125 158.069 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3017408 152.269 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr14_-_19418930 136.827 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3015654 134.808 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr2_-_98667264 125.490 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3018753 122.297 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_+_98662227 96.435 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr10_+_26229707 15.363 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr11_-_11627824 12.972 ENSMUST00000081896.4
 4930512M02Rik
RIKEN cDNA 4930512M02 gene
chr14_+_120749352 12.707 ENSMUST00000138893.2
 Gm17613
predicted gene, 17613
chr3_+_94377432 11.850 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1230.1 GO:0008150 biological_process(GO:0008150)
2.9 20.5 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.5 14.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
4.9 14.7 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
2.4 14.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.9 11.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.1 8.9 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.1 8.5 GO:0006497 protein lipidation(GO:0006497)
1.2 7.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.7 7.2 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
1.7 6.9 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.2 6.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
2.8 5.7 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
1.4 5.6 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
1.4 5.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 5.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.3 5.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 5.1 GO:0048730 epidermis morphogenesis(GO:0048730)
0.1 5.0 GO:0042491 auditory receptor cell differentiation(GO:0042491)
1.5 4.4 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1362.1 GO:0005575 cellular_component(GO:0005575)
0.3 14.7 GO:0044295 axonal growth cone(GO:0044295)
0.4 8.9 GO:0000242 pericentriolar material(GO:0000242)
1.4 7.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.3 5.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.4 5.6 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 4.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.9 3.6 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.6 3.5 GO:0045179 apical cortex(GO:0045179)
0.1 3.5 GO:0043034 costamere(GO:0043034)
0.8 3.4 GO:0031673 H zone(GO:0031673)
0.1 3.3 GO:0034451 centriolar satellite(GO:0034451)
0.2 2.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 2.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.8 GO:0016580 Sin3 complex(GO:0016580)
0.2 0.7 GO:0000811 GINS complex(GO:0000811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1295.5 GO:0003674 molecular_function(GO:0003674)
5.1 20.5 GO:0008142 oxysterol binding(GO:0008142)
0.7 14.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.3 14.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 12.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 11.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 9.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.8 8.9 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 8.2 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.2 7.8 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
2.5 7.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 7.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
1.4 6.9 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 6.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.8 5.6 GO:0015616 DNA translocase activity(GO:0015616)
0.2 5.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 3.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 3.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 3.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.7 3.6 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)