Motif ID: Nfatc4

Z-value: 0.605


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.321.4e-02Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_56978534 8.474 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_48049080 6.252 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr13_+_83504032 5.896 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr19_+_26623419 5.368 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_56969864 5.338 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_-_4943049 3.557 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr2_+_55435918 2.774 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr11_+_97415527 2.590 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr15_+_92051153 2.230 ENSMUST00000169825.1
 Cntn1
contactin 1
chr2_-_66410064 1.966 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr14_+_70555900 1.909 ENSMUST00000163060.1
 Hr
hairless
chr5_+_117363513 1.833 ENSMUST00000111959.1
 Wsb2
WD repeat and SOCS box-containing 2
chr16_+_43364145 1.670 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr13_-_52981027 1.629 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr6_-_59024470 1.578 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr9_+_113812547 1.578 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr1_-_126830632 1.485 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr6_-_59024340 1.376 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr12_+_76533540 1.327 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr19_-_8839181 1.221 ENSMUST00000096259.4
 Gng3
guanine nucleotide binding protein (G protein), gamma 3
chrX_+_7638674 1.206 ENSMUST00000128890.1
 Syp
synaptophysin
chr12_-_84450944 1.205 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr11_+_29692937 1.154 ENSMUST00000102843.3
ENSMUST00000102842.3
ENSMUST00000078830.4
ENSMUST00000170731.1
 Rtn4



reticulon 4



chr1_-_193370225 1.090 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_-_193370260 1.058 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr13_+_31806627 1.046 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr1_+_34005872 1.044 ENSMUST00000182296.1
 Dst
dystonin
chr2_+_116067213 0.954 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr1_-_170110491 0.912 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr2_-_116067391 0.885 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr4_+_130107556 0.756 ENSMUST00000030563.5
 Pef1
penta-EF hand domain containing 1
chr2_-_73660351 0.686 ENSMUST00000154258.1
 Chn1
chimerin (chimaerin) 1
chr2_+_125136692 0.657 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr8_-_64205970 0.654 ENSMUST00000066166.4
 Tll1
tolloid-like
chr11_-_35980473 0.628 ENSMUST00000018993.6
 Wwc1
WW, C2 and coiled-coil domain containing 1
chr3_-_37125943 0.627 ENSMUST00000029275.5
 Il2
interleukin 2
chr14_-_25927672 0.541 ENSMUST00000185006.1
 Tmem254a
transmembrane protein 254a
chr19_+_8839298 0.537 ENSMUST00000160556.1
 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr14_-_25927250 0.504 ENSMUST00000100811.5
 Tmem254a
transmembrane protein 254a
chr3_-_96594128 0.470 ENSMUST00000145001.1
ENSMUST00000091924.3
 Polr3gl

polymerase (RNA) III (DNA directed) polypeptide G like

chr15_-_79062866 0.462 ENSMUST00000151889.1
ENSMUST00000040676.4
 Ankrd54

ankyrin repeat domain 54

chr14_-_26067355 0.458 ENSMUST00000100819.5
 Tmem254c
transmembrane protein 254c
chr1_-_64121456 0.453 ENSMUST00000142009.1
ENSMUST00000114086.1
 Klf7

Kruppel-like factor 7 (ubiquitous)

chrX_+_48623737 0.415 ENSMUST00000114936.1
 Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr14_+_47663756 0.398 ENSMUST00000022391.7
 Ktn1
kinectin 1
chr3_+_94837533 0.381 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr10_+_21993890 0.380 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr1_-_126830786 0.328 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr12_+_91400990 0.303 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr9_-_13446753 0.293 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr11_+_75468040 0.268 ENSMUST00000043598.7
ENSMUST00000108435.1
 Tlcd2

TLC domain containing 2

chr8_-_41041828 0.266 ENSMUST00000051379.7
 Mtus1
mitochondrial tumor suppressor 1
chr1_-_64121389 0.259 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr11_-_47379405 0.233 ENSMUST00000077221.5
 Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr15_-_79932516 0.223 ENSMUST00000177044.1
ENSMUST00000109615.1
ENSMUST00000089293.4
ENSMUST00000109616.2
 Cbx7



chromobox 7



chr7_-_4778141 0.189 ENSMUST00000094892.5
 Il11
interleukin 11
chr12_+_84451485 0.126 ENSMUST00000137170.1
 Lin52
lin-52 homolog (C. elegans)
chr12_-_86079019 0.090 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr7_-_79920599 0.085 ENSMUST00000075657.6
 Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chr15_+_3270767 0.031 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr18_-_62741387 0.021 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
2.0 5.9 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.2 3.6 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.9 13.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 5.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.4 1.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.4 2.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.3 1.0 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.2 1.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.2 2.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 0.5 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
0.2 0.6 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1 0.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 2.8 GO:0010107 potassium ion import(GO:0010107)
0.1 0.5 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 1.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 1.0 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 1.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.1 GO:1905005 regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.0 2.3 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 0.5 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.5 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.3 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 1.9 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 2.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 5.4 GO:0071564 npBAF complex(GO:0071564)
0.3 1.0 GO:0031673 H zone(GO:0031673)
0.1 15.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 5.9 GO:0016607 nuclear speck(GO:0016607)
0.0 2.5 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.0 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 4.3 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 5.9 GO:0003680 AT DNA binding(GO:0003680)
0.4 5.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 1.9 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 1.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 2.0 GO:0031402 sodium ion binding(GO:0031402)
0.1 1.0 GO:0008301 DNA binding, bending(GO:0008301)
0.1 5.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 0.4 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 2.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.4 GO:0019894 kinesin binding(GO:0019894)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 1.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.2 GO:0001948 glycoprotein binding(GO:0001948)
0.0 3.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)
0.0 1.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)