Motif ID: Nfic_Nfib

Z-value: 2.267

Transcription factors associated with Nfic_Nfib:

Gene SymbolEntrez IDGene Name
Nfib ENSMUSG00000008575.11 Nfib
Nfic ENSMUSG00000055053.11 Nfic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nficmm10_v2_chr10_-_81427114_814271870.761.8e-12Click!
Nfibmm10_v2_chr4_-_82505274_825053580.453.3e-04Click!


Activity profile for motif Nfic_Nfib.

activity profile for motif Nfic_Nfib


Sorted Z-values histogram for motif Nfic_Nfib

Sorted Z-values for motif Nfic_Nfib



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfic_Nfib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_43730593 46.977 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr11_+_78324200 43.435 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr6_-_115251839 34.175 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr6_+_135362931 32.012 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr2_-_25469742 30.954 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 30.662 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr8_+_72646679 30.061 ENSMUST00000161386.1
ENSMUST00000093427.4
 Nwd1

NACHT and WD repeat domain containing 1

chr8_+_72646728 27.483 ENSMUST00000161254.1
 Nwd1
NACHT and WD repeat domain containing 1
chr2_-_164404606 26.160 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
 Matn4


matrilin 4


chr10_+_86302854 25.126 ENSMUST00000132307.1
 Timp3
tissue inhibitor of metalloproteinase 3
chr11_+_3488275 23.488 ENSMUST00000064265.6
 Pla2g3
phospholipase A2, group III
chr10_+_57784859 23.335 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr6_+_17306335 22.596 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr1_-_162859684 22.169 ENSMUST00000131058.1
 Fmo1
flavin containing monooxygenase 1
chr16_+_90831113 21.466 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr4_+_130047840 20.999 ENSMUST00000044565.8
ENSMUST00000132251.1
 Col16a1

collagen, type XVI, alpha 1

chr1_+_185454803 20.379 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr7_-_97417730 19.021 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr11_+_78322965 18.051 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr3_+_94933041 17.942 ENSMUST00000090839.5
 Selenbp1
selenium binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
12.3 61.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
12.1 60.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
5.9 59.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
8.0 47.8 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
5.9 47.0 GO:0070314 G1 to G0 transition(GO:0070314)
2.1 37.6 GO:0060134 prepulse inhibition(GO:0060134)
6.0 29.9 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
1.1 29.5 GO:0033622 integrin activation(GO:0033622)
4.0 27.7 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
3.8 26.8 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.5 26.6 GO:0048678 response to axon injury(GO:0048678)
4.3 25.9 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
2.4 24.0 GO:0009404 toxin metabolic process(GO:0009404)
5.9 23.5 GO:0019372 lipoxygenase pathway(GO:0019372)
1.3 23.2 GO:0032060 bleb assembly(GO:0032060)
2.3 20.6 GO:0042940 D-amino acid transport(GO:0042940)
2.3 20.4 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.7 20.2 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
3.1 18.5 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
3.0 17.9 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 115.8 GO:0016021 integral component of membrane(GO:0016021)
0.7 56.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
6.8 47.8 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.1 47.5 GO:0005615 extracellular space(GO:0005615)
0.1 40.2 GO:0030424 axon(GO:0030424)
0.2 37.3 GO:0030017 sarcomere(GO:0030017)
2.0 29.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 26.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
2.9 26.3 GO:0097449 astrocyte projection(GO:0097449)
6.5 25.9 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 25.8 GO:0043025 neuronal cell body(GO:0043025)
0.1 22.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 22.0 GO:0005814 centriole(GO:0005814)
0.2 19.2 GO:0097060 synaptic membrane(GO:0097060)
0.2 17.0 GO:0005604 basement membrane(GO:0005604)
0.4 16.4 GO:0044297 cell body(GO:0044297)
0.2 15.8 GO:0005581 collagen trimer(GO:0005581)
4.9 14.8 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 14.2 GO:0042383 sarcolemma(GO:0042383)
0.2 13.6 GO:0005901 caveola(GO:0005901)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
15.4 61.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
10.2 61.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
4.6 60.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 56.8 GO:0005178 integrin binding(GO:0005178)
2.1 47.8 GO:0051787 misfolded protein binding(GO:0051787)
1.0 38.7 GO:0005504 fatty acid binding(GO:0005504)
2.1 30.8 GO:0008430 selenium binding(GO:0008430)
6.0 29.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
4.5 26.8 GO:0015265 urea channel activity(GO:0015265)
0.9 24.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
4.8 24.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 22.2 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.9 18.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.4 17.7 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.7 16.7 GO:0030506 ankyrin binding(GO:0030506)
2.7 16.4 GO:0019841 retinol binding(GO:0019841)
1.7 14.9 GO:0015643 toxic substance binding(GO:0015643)
4.5 13.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
3.3 13.1 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.3 13.0 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)